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Understanding pathogen, livestock, environment interactions involving bluetongue virus

Deliverables

Adaptation and maintenance of spatial data website to include PALE-Blu data

D12.5: Adaptation and maintenance of spatial data website to include PALE-Blu data (all Partners). (M12)

Updated website with environment / anthropogenic data

D3.2: Updated website with environmental and anthropogenic data archive and dissemination capabilities (Partner 1, 3, 6, 7, 10, 12). (M12)

Project website

Task 12.4: Establish and maintain project website(s) with regular updates over the project lifetime with all partners contributing new material, with review of the site at every consortium meeting. (all Partners) (M1 to M36)

Archive of standardised and processed spatial data

D3.6: Archive of standardised and processed spatial data for use by WP1, WP3, & WP4 (Partner 1, 3, 6, 7, 10, 12). (M24)

Protocol for collection, shipment and onward processing of Culicoides eggs

D6.1: Protocol for collection, shipment and onward processing of Culicoides eggs (Partner 1,11,13,14,16,18). (M24)

Serotype specific qRT-PCR for novel BTV serotypes

D5.1: Serotype specific qRT-PCR for novel BTV serotypes (Partner 1, 2, 4, 5, 12, 16). (M18)

Established friction surfaces and connectivity matrices

D3.4: Established friction surfaces and connectivity matrices (Partner 1, 3, 6, 7, 10, 12). (M24)

Refined spatial epizone maps

D3.3: Refined spatial epizone maps (Partner 1, 3, 6, 7, 10, 12). (M18)

List of required environmental and landscape factors

D4.1: List of required environmental and landscape factors needed (Partner 3, 6, 7) (with WP3). (M3)

Array system for typing BTV

D5.2: Array based system for typing BTV (Partner 1, 4, 5). (M27)

DISA single BTV serotype protection

D10.5: Report on early protection against one serotype in cattle by mono-serotype DISA vaccination (Partners 9). (M24).

Reassortant strains between conventional and novel / atypical strains

D8.2: Reassortant viruses between conventional (e.g. BTV-1 or BTV-4) and novel/atypical strains (e.g. to explore the genetic basis for horizontal transmission (Partners 1, 2, 4, 5). (M18)

Assess pathogenesis / horizontal transmission of BTV strains

D8.1: An assessment of the the pathogenesis and horizontal transmission characteristics of BTV-8, BTV-26, and other ‘novel’ BTV strains in goats and sheep (Partners 2, 4, 5). (M18)

List of spatial data required

D3.1: A list of spatial data requirements from WP1, (Partners 1, 3, 4, 10). (M3)

A mouse model for horizontal transmission of BTV

D8.3: A mouse model for horizontal transmission of atypical BTV strains between mammalian hosts. (Partners 2). (M24)

Identification of BTV genes that support horizontal transmission in mammalian host.

D8.4: Identification of genome segments of the novel/atypical BTV strains/serotypes that support horizontal transmission in a mammalian host (Partners 1, 2, 4, 5). (M24)

Identification of statin doses that inhibit BTV in cell culture

D11.1: Identification of inhibitory doses of statin molecules on selected BTV strains in cell culture (Partner 2). (M24)

Protocol for successful generation of primary cell cultures from different Culicoides spp.

D6.2: Protocol for successful generation of primary cell cultures from different Culicoides spp. (Partner 1). (M27)

Culicoides host maps

D4.3: Culicoides host maps as determined by available data (Partners 3, 6, 7). (M30)

Spatial data base of vector distributions

D4.2: Spatial data base of vector distributions (Partner 3, 4, 6, 7, 12). (M12)

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Publications

Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference

Author(s): Maude Jacquot, Kyriaki Nomikou, Massimo Palmarini, Peter Mertens, Roman Biek
Published in: Proceedings of the Royal Society B: Biological Sciences, Issue 284/1864, 2017, Page(s) 20170919, ISSN 0962-8452
DOI: 10.1098/rspb.2017.0919

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of African Horse Sickness Virus

Author(s): V. L. Fowler, E. L. A. Howson, J. Flannery, M. Romito, A. Lubisi, M. Agüero, P. Mertens, C. A. Batten, H. R. Warren, J. Castillo-Olivares
Published in: Transboundary and Emerging Diseases, Issue 64/5, 2017, Page(s) 1579-1588, ISSN 1865-1674
DOI: 10.1111/tbed.12549

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Author(s): Cristina C. Celma, Meredith Stewart, Kerstin Wernike, Michael Eschbaumer, Lorenzo Gonzalez-Molleda, Emmanuel Breard, Claudia Schulz, Bernd Hoffmann, Andy Haegeman, Kris De Clercq, Stephan Zientara, Piet A. van Rijn, Martin Beer, Polly Roy
Published in: Journal of Virology, Issue 91/1, 2016, ISSN 0022-538X
DOI: 10.1128/JVI.01892-16