Objective
In recent years, macroscale drug delivery systems have been designed and investigated to spatiotemporally control the release of various bioactive agents and drugs at specific locations in the body. Many of these macroscale drug delivery vehicles are based on hydrogels. Depending on the location of application, and the temporal release kinetics, these hydrogel drug carriers need to be adjusted to the need of the application. Many of the currently available hydrogel systems do not have the capacity to be totally tuned. These systems: a) display a substantial initial burst release of the drug resulting in high drug doses at the initial phase; b) are difficult to apply (surgical implantation is necessary for various systems, thereby limiting their potential of easy/convenient application); c) provide only limited opportunities for chemical adjustment of their composition to improve key material properties such as their release kinetics and/or degradation rate. SupraCarrier aims to address these unmet needs by developing an injectable, supramolecular ureido-pyrimidinone (UPy) based hydrogel (UPy-hydrogel) drug delivery system that allows for local and sustained drug release. The unique selling points of this UPy-hydrogel system are: a) its demonstrated sustained drug release profile in vitro (with no initial burst release); b) its injectability due to its unique physicochemical properties (that allow for the development of clinical strategies using minimally invasive procedures); and c) its chemical structure and supramolecular assembly behaviour which allows for easy modification of either the UPy-hydrogel carrier or the drug (resulting in a versatile drug delivery platform). With SupraCarrier we aim to a) validate the commercial feasibility of a UPy-hydrogel as a novel local drug delivery system for controlled (and sustained) drug release; b) prioritise the medical applications where this system can be used; and c) provide a proof of concept for using a UPy-hydrogel
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2016-PoC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.