Objective
Assessment study of the allergy-producing levels of chemical substances present in cutting oils and solvents used in the electro-mechanical maintenance, cold rolling and cylinder re-boring sectors.
Maximum permissible doses of chemical agents in terms of retarded skin allergy development shall be established with a view to determining safety levels that allow the production of less aggressive formulations by mixing chemical substances with the same technological action but at a previously set safety level. This should lead to equally efficient formulations.
Bioassays shall be carried out in accordance with methods certified by the EC.
METHODS AND MEANS BY WHICH THE AIMS ARE TO BE ACHIEVED
There are two preferred methods:
- the Buehler test (without use of FCA (Freunds Complete Adjuvant))
- the guinea-pig maximisation test, GPMT (with use of FCA).
Part of the work will be carried out by the group Interlab, which operates physico-chemical and in-vivo and in-vitro toxicology laboratories to the strictest GLP (good laboratory practice) standards.
The work will be supervised and coordinated by ENSIDESA, which will assume scientific control of the research.
Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
33480 AVILES
Spain