INfraStructure in Proton International REsearch

Informations projet

INSPIRE

N° de convention de subvention: 730983

DOI 10.3030/730983

Projet clôturé

Date de signature de la CE 25 Janvier 2018

Date de début 1 Mars 2018

Date de fin 31 Decembre 2022

Financé au titre de

• EXCELLENT SCIENCE - Research Infrastructures

Coût total € 4 999 867,00

Contribution de l’UE € 4 999 867,00

Coordonné par

THE UNIVERSITY OF MANCHESTER
United Kingdom

Livrables

Documents, reports (14)

Report Recalculation of treatment plans performed assuming a constant RBE=1.1, with two different models for variable RBE, including dependencies on beam quality, dose fractionation, OER and tissue type

Study of the effects of using a variable RBE on treatment planning and how factors such as fractionation, OER and beam quality affect this plan. Combination of experimental and theoretical studies. Due Date (in months): 36

TNA providers have QA documentation in place

All TNA providers have QA documentation in place on their experimental protocols and operational procedures. For example for dosimetry, spot scanning, energy verification. Due Date (in months): 12

Benchmark radiobiological models of hypoxia against experimental data; prepare paper for publication

Compare experimental and simulation studies on the effects of tumour cell growth in hypoxic environments and the effects of PBT and how this differs to photons Prepare paper for publicationDue Date in months 58

Evaluate detectors for measuring range uncertainties and evaluate opportunities of using nanoparticles to enhance signals

Use nanoparticles to enhance prompt gamma signal for range verification. Evaluate the use of nanoparticles to enhance detector signal. Due Date (in months): 40

Public Engagement factsheets & other information available in a number of languages on Open Access Gateway

Factsheets on PBT will be available for the general public and policy makers in a number of languages through the part of the INSPIRE Access Gateway aimed at engaging stakeholders.Due Date (in months): 12

6 monthly INSPIRE Newsletter

Electronic Newsletter to describe NA TNA and JRA achievements of INSPIRE This will be compiled every 6 monthsDue Date in months 12 18 24 30 36 42 48 54

Report on post-treatment assessment of actually delivered dose in patients

IC will oversee the analysis of the analytical and MC planning systems comparing the different models and their performance and evaluate the incidence of biological models on virtual planning and then report on their findingsDue Date in months 58

Definition of key parameters for NTCP based patient selection and tumour sites

Discussion of key tumour sites and development of NTCP models for those sites. Sharing of results between interested partners. Due Date (in months): 12

Mid term & Final Report on Innovation Gateway with toolkit of Activities

Reports on the activities of the Innovation Gateway Outlining industrial involvement and participation within INSPIRE through use of the toolkit of activitiesDue Date in months 24 58

Sustainability Report for INSPIRE

Report on the sustainability of INSPIRE. Development of INSPIRE and positioning it to become an advanced research community.Due Date (in months): 58

Reports to management boards on TNA provision

QA for TNA will be provided to management meetings in terms of TNA provided turnaround times user feedback benchmarking and interoperability experiments quantity and quality of outputs including publications grants patents etc user engagement including industry and hospitals training courses placement and secondments use of the Innovation Gateway This will allow the performance of each TNA provider to be monitored and measured against INSPIREs deliverables and Milestones Due Date in months 6 12 18 24 30 36 42 48 54 58

Protocols for in vitro analysis of dose response of radio sensitising agents with protons; prepare paper for publication

Establish protocols for in vitro studies of PBT in combination with radio sensitising agents. Prepare paper for publication. Due Date (in months): 36

Preliminary experiments to investigate radio-protective effects of hibernation on small animals, prepare paper for publication

Develop experiments to test the hypothesis that there are radio-protective effects due to hibernation. Prepare paper for publication. Due Date (in months): 40

Data Management Plan & Dissemination & Exploitation Plan

A comprehensive data management plan (DMP) will be drawn up for INSPIRE. A draft of INSPIRE’s dissemination and exploitation plan can be found in section 2.2(a) and its roadmap is shown in Figure 7. Due Date (in months): 5

Other (6)

Deliver training courses outlined in table 3.1.1

A series of Training Courses will be established for New Users. This will use a combination of established courses such as the PSI Proton Winter School in PBT and new courses where we have established from a “gap analysis” that there is a new user need. These are described in shown Table 3.1.1 in Annex A. Where possible we would seek to run these courses in conjunction with other EU projects. Due Date (in months): 58

Annual INSPIRE Information Day in participating countries and other EU member states on request

Every year, each participant will hold an INSPIRE Information Day. This will bring those interested in PBT together, provide a training opportunity on PBT and promote the TNA and NA opportunities within INSPIRE as well as giving the latest updates on JRA. Due Date (in months): 6, 18, 30, 42, 54

User selection Panel appointed

Independent reviewers of proposals for TNA appointed and given information on how they expected to review proposals. Due Date (in months): 6

INSPIRE delivers 612 hrs of TNA by month 48

Monitoring of TNA delivery to ensure 612 hours of TNA are delivered by month 48.Due Date (in months): 58

Open Nights programme commenced

INSPIRE will have an “Open Nights” programme for all of the PBT centres who wish to participate. This is an idea that has been pioneered by IFJPAN and allows the opportunity for the public to see around both the research room and the clinical facilities, ask questions and hear about the research being conducted within INSPIRE. Due Date (in months): 12

15 Discipline Hops and summer placements have taken place

Early career researchers (ECR) will also be offered the opportunity of “Discipline Hops” which will enable them to spend a period of 2 to 3 months at a PBT centre, either in the clinical environment or in clinical medical physics (or both), where they will also have the opportunity to take part in the JRA activities in that centre. “Discipline Hops” will also be available for ECRs who wish to experience the PBT industrial environment. Due Date (in months): 58

Demonstrators, pilots, prototypes (3)

Development and testing of advanced radiobiological phantoms / end-stations for RBE experiments along the Bragg peak using spot scanning or passive scattering

Development of equipment / phantoms to study the change in relative biological effectiveness along the Bragg peak.Due Date (in months): 58

Incorporation of PBT indications into Malthus decision trees

Incorporating decision trees for UK PBT indications in to Malthus model for modelling radiotherapy demand. Due Date (in months): 12

Develop tissue equivalent phantoms for monitoring dosimetry and changes in RBE along the Bragg peak

Develop materials which can be used as tissue equivalent for PBT and use 3D printing technology to build phantoms which can be used in round-robin experiments.Due Date (in months): 42

Websites, patent fillings, videos etc. (2)

INSPIRE Access Gateway, Knowledge Hub, Help Desk and Open Access Portal

INSPIRE web portal now includes a Knowledge Hub for those interested in finding out more about PBT and for sharing best practice. Open Access Portal developed for sharing results and publications and information about INSPIRE through NA.Due Date (in months): 8

Access Gateway designed and launched

INSPIRE web portal which comprises INSPIRE Access Gateway (for NA, TNA and JRA) and is specified, designed, tested using a proto-type and then launched so it can be used by partners and the wider EU community. Due Date (in months): 6

Open Research Data Pilot (1)

Open Access to Research data

Open access to research data pilot

Publications

Peer reviewed articles (85)

Proton therapy and the European Particle Therapy Network: The past, present and future

Auteurs: D C Weber, J A Langendijk, C Grau, J Thariat
Publié dans: Cancer Radiotherapie, 2020, ISSN 1278-3218
Éditeur: Elsevier Masson

Shortening delivery times for intensity-modulated proton therapy by reducing the number of proton spots: an experimental verification

Auteurs: van de Water, Steven; Belosi, Maria F; Albertini, Francesca; Winterhalter, Carla; Weber, Damien C; Lomax, Antony J
Publié dans: Physics in Medicine & Biology, Numéro 21, 2020, ISSN 0031-9155
Éditeur: Institute of Physics Publishing

Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy

Auteurs: Makbule Tambas, Hans P. van der Laan, Wouter Rutgers, Johanna G.M. van den Hoek, Edwin Oldehinkel, Tineke W.H. Meijer, Arjen van der Schaaf, Daniel Scandurra, Jeffrey Free, Stefan Both, Roel J.H.M. Steenbakkers, Johannes A. Langendijk
Publié dans: Radiotherapy and Oncology, Numéro 160, 2021, Page(s) 61-68, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2021.04.012

Carbon Ion Radiobiology

Auteurs: Walter Tinganelli, Marco Durante
Publié dans: Cancers, Numéro 12/10, 2020, Page(s) 3022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12103022

Late Side Effects in Normal Mouse Brain Tissue After Proton Irradiation

Auteurs: Theresa Suckert, Elke Beyreuther, Johannes Müller, Behnam Azadegan, Matthias Meinhardt, Felix Raschke, Elisabeth Bodenstein, Cläre von Neubeck, Armin Lühr, Mechthild Krause, Antje Dietrich
Publié dans: Frontiers in Oncology, Numéro 10, 2021, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.598360

Ultra-high dose rate (FLASH) carbon ion irradiation: dosimetry and first cell experiments.

Auteurs: Walter Tinganelli; Olga Sokol; Martina Quartieri; Anggraeini Puspitasari; Ivana Dokic; Ivana Dokic; Amir Abdollahi; Amir Abdollahi; Marco Durante; Thomas Haberer; Jürgen Debus; Jürgen Debus; Daria Boscolo; Bernd Voss; Stephan Brons; Christoph Schuy; Felix Horst; Ulrich Weber
Publié dans: International Journal of Radiation Oncology*Biology*Physics, Numéro 9, 2022, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1016/j.ijrobp.2021.11.020

Multi-modality bedding platform for combined imaging and irradiation of mice

Auteurs: Johannes Müller, Michael Schürer, Christian Neubert, Falk Tillner, Elke Beyreuther, Theresa Suckert, Nils Peters, Cläre von Neubeck, Armin Lühr, Mechthild Krause, Rebecca Bütof, Antje Dietrich
Publié dans: Biomedical Physics & Engineering Express, Numéro 6/3, 2020, Page(s) 037003, ISSN 2057-1976
Éditeur: IOP Publishing
DOI: 10.1088/2057-1976/ab79f1

Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer.

Auteurs: Karen J. Kirkby; Karen J. Kirkby; Norman F. Kirkby; Norman F. Kirkby; Neil G. Burnet; Neil G. Burnet; Hywel Owen; Ranald I Mackay; Ranald I Mackay; Adrian Crellin; Adrian Crellin; Stuart Green
Publié dans: The British Journal of Radiobiology, Numéro 1, 2020, Page(s) Vol 93, No. 1116, ISSN 1748-880X
Éditeur: The British Institute of Radiobiology
DOI: 10.1259/bjr.20200247

Neutron Radiation Dose Measurements in a Scanning Proton Therapy Room: Can Parents Remain Near Their Children During Treatment?

Auteurs: Mares V, Farah J, De Saint-Hubert M, Domański S, Domingo C, Dommert M, Kłodowska M, Krzempek K, Kuć M, Martínez-Rovira I, Michaś E, Mojżeszek N, Murawski Ł, Ploc O, Romero-Expósito M, Tisi M, Trompier F, Van Hoey O, Van Ryckeghem L, Wielunski M, Harrison RM, Stolarczyk L, Olko P
Publié dans: Front Oncol, Numéro 2234943X, 2022, Page(s) 903706, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.903706

Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

Auteurs: N. T. Henthorn, J. W. Warmenhoven, M. Sotiropoulos, A. H. Aitkenhead, E. A. K. Smith, S. P. Ingram, N. F. Kirkby, A. L. Chadwick, N. G. Burnet, R. I. Mackay, K. J. Kirkby, M. J. Merchant
Publié dans: RSC Advances, Numéro 9/12, 2019, Page(s) 6845-6858, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8ra10168j

Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy

Auteurs: Joanna Depciuch, Justyna Miszczyk, Alexey Maximenko, Piotr M. Zielinski, Kamila Rawojć, Agnieszka Panek, Pawel Olko, Magdalena Parlinska-Wojtan
Publié dans: International Journal of Molecular Sciences, Numéro 21/23, 2020, Page(s) 9082, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239082

Modeling Radioimmune Response—Current Status and Perspectives

Auteurs: Thomas Friedrich, Nicholas Henthorn, Marco Durante
Publié dans: Frontiers in Oncology, Numéro 11, 2021, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.647272

Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties

Auteurs: Apostolos Raptis, Jakob Ödén, Oscar Ardenfors, Anna M. Flejmer, Iuliana Toma-Dasu, Alexandru Dasu
Publié dans: Physica Medica, Numéro 76, 2020, Page(s) 1-6, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2020.06.012

Oxygen Depletion in Proton Spot Scanning: A Tool for Exploring the Conditions Needed for FLASH

Auteurs: Bethany C. Rothwell, Matthew Low, Norman F. Kirkby, ,Michael J. Merchant, Amy L. Chadwick, Ranald I. Mackay, Jolyon H. Hendry and Karen J. Kirkby
Publié dans: Radiation 2021, 2021, ISSN 2673-592X
Éditeur: MDPI
DOI: 10.3390/radiation1040024

Out-of-field measurements and simulations of a proton pencil beam in a wide range of dose rates using a Timepix3 detector: Dose rate, flux and LET

Auteurs: Cristina Oancea, Carlos Granja, Lukas Marek, Jan Jakubek, Jaroslav Šolc, Elisabeth Bodenstein, Sebastian Gantz, Jorg Pawelke, Jiri Pivec
Publié dans: Physica Medica, Numéro Vol 106, 2023, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2023.102529

An Update to the Malthus Model for Radiotherapy Utilisation in England

Auteurs: S. Heritage, S. Sundaram, N.F. Kirkby , K.J. Kirkby, T. Mee , R. Jena
Publié dans: Clinical Oncolgy, Numéro Vol 35, Numéro 1, 2023, ISSN 0936-6555
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.clon.2022.06.006

Commentary: RBE in proton therapy – where is the experimental in vivo data?

Auteurs: Brita Singers Sørensen
Publié dans: Acta Oncologica, Numéro 58/10, 2019, Page(s) 1337-1339, ISSN 0284-186X
Éditeur: Taylor & Francis
DOI: 10.1080/0284186x.2019.1669819

Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter

Auteurs: Oluwasayo Loto, Izabella Zahradnik, Amelia Maia Leite, Ludovic De Marzi, Dominique Tromson, Michal Pomorski
Publié dans: Sensors, Numéro 21/4, 2021, Page(s) 1314, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21041314

Combined proton radiography and irradiation for high-precision preclinical studies in small animals

Auteurs: Moritz Schneider, Elisabeth Bodenstein, Johanna Bock, Antje Dietrich, Sebastian Gantz, Lena Heuchel, Mechthild Krause, Armin Lühr, Cläre von Neubeck, Sindi Nexhipi, Michael Schürer, Falk Tillner, Elke Beyreuther, Theresa Suckert, Johannes Richard Müller
Publié dans: Frontiers in Oncology, 2022, ISSN 0000-0000
Éditeur: Frontiers
DOI: 10.3389/fonc.2022.982417

Proton beam therapy: perspectives on the National Health Service England clinical service and research programme

Auteurs: Neil G Burnet, Ranald I Mackay, Ed Smith, Amy L Chadwick, Gillian A Whitfield, David J Thomson, Matthew Lowe, Norman F Kirkby, Adrian M Crellin, Karen J Kirkby
Publié dans: The British Journal of Radiology, Numéro 93/1107, 2020, Page(s) 20190873, ISSN 0007-1285
Éditeur: British Institute of Radiology
DOI: 10.1259/bjr.20190873

Ultra-fast pencil beam scanning proton therapy for locally advanced non-small-cell lung cancers: Field delivery within a single breath-hold

Auteurs: VivekMaradia, Steven van de Water, David Meer, Damien C.Weber, Antony J.Lomax, SerenaPsoroulas
Publié dans: Radiotherapy and Oncology, 2022, Page(s) 23-29, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2022.06.018

The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on the In Vitro Wound Healing Process

Auteurs: Radstake, W.E.; Gautam, K.; Miranda, S.; Vermeesen, R.; Tabury, K.; Rehnberg, E.; Buset, J.; Janssen, A.; Leysen, L.; Neefs, M.; Verslegers, M.; Claesen, J.; van Goethem, M.-J.; Weber, U.; Fournier, C.; Parisi, A.; Brandenburg, S.; Durante, M.; Baselet, B.; Baatout, S.
Publié dans: Cells, 2023, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells12020246

Proton Radiographs Using Position-Sensitive Silicon Detectors and High-Resolution Scintillators

Auteurs: J. A. Briz et al
Publié dans: IEEE Transactions on Nuclear Science, Numéro Volume 69 Numéro 4, 2022, ISSN 0018-9499
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tns.2022.3142618

A Monte Carlo study of different LET definitions and calculation parameters for proton beam therapy

Auteurs: Edward A K Smith, Carla Winterhalter, Tracy S A Underwood, Adam H Aitkenhead, Jenny C Richardson, Michael J Merchant, Norman F Kirkby, Karen J Kirby and Ranald I Mackay
Publié dans: Biomedical Physics & Engineering Express, Numéro Vol 8, 1, 2021, ISSN 2057-1976
Éditeur: Institute of Physics
DOI: 10.1088/2057-1976/ac3f50

Spatial correlation of linear energy transfer and relative biological effectiveness with suspected treatment‐related toxicities following proton therapy for intracranial tumors

Auteurs: Jakob Ödén, Iuliana Toma‐Dasu, Petra Witt Nyström, Erik Traneus, Alexandru Dasu
Publié dans: Medical Physics, Numéro 47/2, 2020, Page(s) 342-351, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.13911

Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies

Auteurs: Pierre Lansonneur, Vincent Favaudon, Sophie Heinrich, Charles Fouillade, Pierre Verrelle, Ludovic De Marzi
Publié dans: Physica Medica, Numéro 60, 2019, Page(s) 50-57, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2019.03.016

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

Auteurs: Vincenzo Patera, Yolanda Prezado, Faical Azaiez, Giuseppe Battistoni, Diego Bettoni, Sytze Brandenburg, Aleksandr Bugay, Giacomo Cuttone, Denis Dauvergne, Gilles de France, Christian Graeff, Thomas Haberer, Taku Inaniwa, Sebastien Incerti, Elena Nasonova, Alahari Navin, Marco Pullia, Sandro Rossi, Charlot Vandevoorde, Marco Durante
Publié dans: Frontiers in Physics, Numéro 8, 2020, ISSN 2296-424X
Éditeur: Frontiers Media
DOI: 10.3389/fphy.2020.00380

Mechanistic Modelling of Slow and Fast NHEJ DNA Repair Pathways Following Radiation for G0/G1 Normal Tissue Cells

Auteurs: Yaping Qi,John William Warmenhoven,Nicholas Thomas Henthorn, Samuel Peter Ingram,Xie George Xu,Karen Joy Kirkby and Michael John Merchant
Publié dans: Cancers 2021, Numéro 13 (9), 2021, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092202

Biological Impact of Target Fragments on Proton Treatment Plans: An Analysis Based on the Current Cross-Section Data and a Full Mixed Field Approach.

Auteurs: Elettra Valentina Bellinzona; Leszek Grzanka; Andrea Attili; Francesco Tommasino; Thomas Friedrich; Michael Kramer; Michael Scholz; Giuseppe Battistoni; A. Embriaco; Davide Chiappara; G.A.P. Cirrone; Giada Petringa; Marco Durante; Emanuele Scifoni
Publié dans: Cancers, Numéro 1, 2021, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13194768

Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage

Auteurs: Samuel P. Ingram, Nicholas T. Henthorn, John W. Warmenhoven, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publié dans: PLOS Computational Biology, Numéro 16/12, 2020, Page(s) e1008476, ISSN 1553-7358
Éditeur: PLOS
DOI: 10.1371/journal.pcbi.1008476

High-precision image-guided proton irradiation of mouse brain sub-volumes

Auteurs: Theresa Suckert, Johannes Müller, Elke Beyreuther, Behnam Azadegan, Anja Brüggemann, Rebecca Bütof, Antje Dietrich, Malte Gotz, Robert Haase, Michael Schürer, Falk Tillner, Cläre von Neubeck, Mechthild Krause, Armin Lühr
Publié dans: Radiotherapy and Oncology, Numéro 146, 2020, Page(s) 205-212, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2020.02.023

RBE for proton radiation therapy – a Nordic view in the international perspective

Auteurs: Iuliana Toma-Dasu, Alexandru Dasu, Anne Vestergaard, Petra Witt Nyström, Håkan Nyström
Publié dans: Acta Oncologica, Numéro 59/10, 2020, Page(s) 1151-1156, ISSN 0284-186X
Éditeur: Taylor & Francis
DOI: 10.1080/0284186x.2020.1826573

Predicting late magnetic resonance image changes in glioma patients after proton therapy

Auteurs: J. Eulitz, E.G.C. Troost, F. Raschke, E. Schulz, B. Lutz, A. Dutz, S. Löck, P. Wohlfahrt, W. Enghardt, C. Karpowitz, M. Krause, A. Lühr
Publié dans: Acta Oncologica, Numéro 58/10, 2019, Page(s) 1536-1539, ISSN 0284-186X
Éditeur: Taylor & Francis
DOI: 10.1080/0284186x.2019.1631477

Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo

Auteurs: Leonhard Karsch, Jörg Pawelke, Michael Brand, Stefan Hans, Katalin Hideghéty, Jeannette Jansen, Elisabeth Lessmann, Steffen Löck, Michael Schürer, Rico Schurig, Joao Seco, Emília Rita Szabó, Elke Beyreuther
Publié dans: Radiotherapy and Oncology, 2022, Page(s) 49-54, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2022.05.025

Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy?

Auteurs: Brita S. Sørensen, Jörg Pawelke, Julia Bauer, Neil G. Burnet, Alexandru Dasu, Morten Høyer, Christian P. Karger, Mechthild Krause, Marco Schwarz, Tracy S.A. Underwood, Dirk Wagenaar, Gillian A. Whitfield, Armin Lühr
Publié dans: Radiotherapy and Oncology, Numéro 163, 2021, Page(s) 177-184, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2021.08.016

Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

Auteurs: Nicholas T. Henthorn, Olga Sokol, Marco Durante, Ludovic De Marzi, Frederic Pouzoulet, Justyna Miszczyk, Pawel Olko, Sytze Brandenburg, Marc Jan van Goethem, Lara Barazzuol, Makbule Tambas, Johannes A. Langendijk, Marie Davídková, Vladimír Vondráĉek, Elisabeth Bodenstein, Joerg Pawelke, Antony J. Lomax, Damien C. Weber, Alexandru Dasu, Bo Stenerlöw, Per R. Poulsen, Brita S. Sørensen, Cai Gr
Publié dans: Frontiers in Physics, Numéro 8, 2020, ISSN 2296-424X
Éditeur: Frontiers Media
DOI: 10.3389/fphy.2020.565055

Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

Auteurs: B C Rothwell, N F Kirkby, M J Merchant, A L Chadwick, M Lowe, R I Mackay, J H Hendry, K J Kirkby
Publié dans: Physics in Medicine & Biology, Numéro 66/5, 2021, Page(s) 055020, ISSN 0031-9155
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6560/abe2ea

A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci

Auteurs: Samuel P. Ingram; John-William Warmenhoven; Nicholas T. Henthorn; Amy L. Chadiwck; Elham E. Santina; Stephen J. McMahon; Jan Schuemann; Norman F. Kirkby; Ranald I. Mackay; Karen J. Kirkby; Michael J. Merchant
Publié dans: Communications Biology, Numéro 1, 2022, Page(s) 5 Article number: 700 (2022), ISSN 2399-3642
Éditeur: Communications Biology
DOI: 10.1038/s42003-022-03585-5

Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy

Auteurs: Neil G Burnet, Thomas Mee, Simona Gaito, Norman F Kirkby, Adam H Aitkenhead, Carmel N Anandadas, Marianne C Aznar, Lisa H Barraclough, Gerben Borst, Frances C Charlwood, Matthew Clarke, Rovel J Colaco, Adrian M Crellin, Noemie N Defourney, Christina J Hague, Margaret Harris, Nicholas T Henthorn, Kirsten I Hopkins, E Hwang, Sam P Ingram, Karen J Kirkby, Lip W Lee, David Lines, Zoe Lingard, Matthew
Publié dans: British Journal of Radiology, Numéro Br J Radiol 2022; 95: 20211175, 2022, ISSN 0007-1285
Éditeur: British Institute of Radiology
DOI: 10.1259/bjr.20211175

Comparative Proton and Photon Irradiation Combined with Pharmacological Inhibitors in 3D Pancreatic Cancer Cultures

Auteurs: Josephine Görte, Elke Beyreuther, Erik H. J. Danen, Nils Cordes
Publié dans: Cancers, Numéro 12/11, 2020, Page(s) 3216, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12113216

3D high resolution clonogenic survival measurement of xrs-5 cells in low-dose region of carbon ion plans

Auteurs: Dea Kartini, Olga Sokol, Chutima Talabnin, Chinorat Kobdaj, Marco Durante, Michael Krämer, Martina Fuss
Publié dans: International Journal of Radiation Biology, 2022, ISSN 0955-3002
Éditeur: Taylor & Francis
DOI: 10.1080/09553002.2022.2110318

Spread-out Bragg Peak in Spatially Fractionated Proton Therapy

Auteurs: A.Toboła, J. Swakoń, P. Olko
Publié dans: Acta Phys. Pol. B, 2022, Page(s) Proc. Suppl. 15, 4-A3, ISSN 2082-7865
Éditeur: Jagiellonian University
DOI: 10.5506/aphyspolbsupp.15.4-a3

Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as function of treatment plan parameters

Auteurs: Van Hoey O, Stolarczyk L, Lillhök J, Eliasson L, Mojzeszek N, Liszka M, Alkhiat A, Mares V, Trompier F, Trinkl S, Martínez-Rovira I, Romero-Expósito M, Ploc O, Harrison R, Olko P
Publié dans: Front Oncol, Numéro 2234943X, 2022, Page(s) 903537, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.903537

Harnessing radiation to improve immunotherapy: better with particles?

Auteurs: Marco Durante, Silvia Formenti
Publié dans: The British Journal of Radiology, Numéro 93/1107, 2020, Page(s) 20190224, ISSN 0007-1285
Éditeur: British Institute of Radiology
DOI: 10.1259/bjr.20190224

Applying Tissue Slice Culture in Cancer Research—Insights from Preclinical Proton Radiotherapy

Auteurs: Theresa Suckert, Treewut Rassamegevanon, Johannes Müller, Antje Dietrich, Antonia Graja, Michael Reiche, Steffen Löck, Mechthild Krause, Elke Beyreuther, Cläre von Neubeck
Publié dans: Cancers, Numéro 12/6, 2020, Page(s) 1589, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061589

Secondary neutron dose contribution from pencil beam scanning, scattered and spatially fractionated proton therapy.

Auteurs: A. M. M. Leite; A. M. M. Leite; M G Ronga; M Giorgi; Y Ristic; Yann Perrot; François Trompier; Yolanda Prezado; G Créhange; L. De Marzi; L. De Marzi
Publié dans: Physics in Medicine & Biology, Numéro 1, 2021, ISSN 0031-9155
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ac3209

Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor

Auteurs: Walter Tinganelli, Timna Hitrec, Fabrizio Romani, Palma Simoniello, Fabio Squarcio, Agnese Stanzani, Emiliana Piscitiello, Valentina Marchesano, Marco Luppi, Maximiliano Sioli, Alexander Helm, Gaetano Compagnone, Alessio Morganti, Roberto Amici, Matteo Negrini, Antonio Zoccoli, Marco Durante, Matteo Cerri
Publié dans: International Journal of Molecular Sciences, Numéro 20/2, 2019, Page(s) 352, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20020352

In Vitro Comparison of Passive and Active Clinical Proton Beams

Auteurs: Anna Michaelidesová, Jana Vachelová, Jana Klementová, Tomáš Urban, Kateřina Pachnerová Brabcová, Stanislav Kaczor, Martin Falk, Iva Falková, Daniel Depeš, Vladimír Vondráček, Marie Davídková
Publié dans: International Journal of Molecular Sciences, Numéro 21/16, 2020, Page(s) 5650, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165650

Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids

Auteurs: Max Naumann, Tabea Czempiel, Anna Jana Lößner, Kristin Pape, Elke Beyreuther, Steffen Löck, Stephan Drukewitz, Alexander Hennig, Cläre von Neubeck, Barbara Klink, Mechthild Krause, Doreen William, Daniel E. Stange, Rebecca Bütof, Antje Dietrich
Publié dans: Cancers, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153781

A Decision Support Tool to Optimize Selection of Head and Neck Cancer Patients for Proton Therapy

Auteurs: Makbule Tambas,Hans Paul van der Laan, Arjen van der Schaaf, Roel J. H. M. Steenbakkers and Johannes Albertus Langendijk
Publié dans: Cancers, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030681

Radiomics-based tumor phenotype determination based on medical imaging and tumor microenvironment in a preclinical setting

Auteurs: Johannes Müller, Stefan Leger, Alex Zwanenburg, Theresa Suckert, Armin Lühr, Elke Beyreuther, Cläre von Neubeck, Mechthild Krause, Steffen Löck, Antje Dietrich, Rebecca Bütof
Publié dans: Radiotherapy and Oncology, 2022, Page(s) 96-104, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2022.02.020

Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model

Auteurs: Brita Singers Sørensen, Mateusz Krzysztof Sitarz, Christina Ankjærgaard, Jacob G. Johansen, Claus E. Andersen, Eleni Kanouta, Cai Grau, Per Poulsen
Publié dans: Radiotherapy and Oncology, Numéro Vol 175, 2022, Page(s) 178-184, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2022.05.014

The suitability of micronuclei as markers of relative biological effect

Auteurs: Charlotte J Heaven, Hannah C Wanstall, Nicholas T Henthorn, John-William Warmenhoven, Samuel P Ingram, Amy L Chadwick, Elham Santina, Jamie Honeychurch, Christine K Schmidt, Karen J Kirkby, Norman F Kirkby, Neil G Burnet, Michael J Merchant
Publié dans: Mutagenesis, Numéro Vol 37, 1, 2022, Page(s) 3-12, ISSN 0267-8357
Éditeur: Oxford University Press
DOI: 10.1093/mutage/geac001

Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage

Auteurs: K. L. Small, N. T. Henthorn, D. Angal-Kalinin, A. L. Chadwick, E. Santina, A. Aitkenhead, K. J. Kirkby, R. J. Smith, M. Surman, J. Jones, W. Farabolini, R. Corsini, D. Gamba, A. Gilardi, M. J. Merchant & R. M. Jones
Publié dans: Scientific Reports, 2021, ISSN 0000-0000
Éditeur: Scientific Reports
DOI: 10.1038/s41598-021-82772-6

Virus Irradiation and COVID-19 Disease

Auteurs: Marco Durante, Kai Schulze, Sebastien Incerti, Ziad Francis, Sara Zein, Carlos Alberto Guzmán
Publié dans: Frontiers in Physics, Numéro 8, 2020, ISSN 2296-424X
Éditeur: Frontiers Media
DOI: 10.3389/fphy.2020.565861

Reduction of Lung Metastases in a Mouse Osteosarcoma Model Treated With Carbon Ions and Immune Checkpoint Inhibitors

Auteurs: Alexander Helm, Walter Tinganelli, Palma Simoniello, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa, Marco Durante
Publié dans: International Journal of Radiation Oncology*Biology*Physics, Numéro 109/2, 2021, Page(s) 594-602, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1016/j.ijrobp.2020.09.041

Advanced Sandwich Composite Cores for Patient Support in Advanced Clinical Imaging and Oncology Treatment

Auteurs: Robert H. Morris, Nicasio R. Geraldi, Lucy C. Pike, Jörg Pawelke, Aswin L. Hoffmann, Nicola Doy, Johanna L. Stafford, Abi Spicer, Michael I. Newton
Publié dans: Materials, Numéro 13/16, 2020, Page(s) 3549, ISSN 1996-1944
Éditeur: MDPI Open Access Publishing
DOI: 10.3390/ma13163549

Uncertainty of RBE Model in Proton Radiotherapy Based on $\frac {\alpha }{\beta }$ Ratio and Linear Energy Transfer

Auteurs: K. Jeleń, L. Grzanka, P. Olko
Publié dans: Acta Physica Polonica B, Numéro 51/1, 2020, Page(s) 405, ISSN 0587-4254
Éditeur: Jagellonian University
DOI: 10.5506/aphyspolb.51.405

Experimental characterisation of a proton kernel model for pencil beam scanning techniques

Auteurs: L. De Marzi, A. Da Fonseca, C. Moignier, A. Patriarca, F. Goudjil, A. Mazal, I. Buvat, J. Hérault
Publié dans: Physica Medica, Numéro 64, 2019, Page(s) 195-203, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2019.07.013

Impact of spot reduction on the effectiveness of rescanning in pencil beam scanned proton therapyfor mobile tumours

Auteurs: Stefanie Bertschi6, Miriam Krieger, Damien C Weber, Antony J Lomax and Steven van de Water
Publié dans: Physics in Medicine & Biology, Numéro Vol 67, 21, 2022, ISSN 0031-9155
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ac96c5

Characterization of 2D Al2O3:C,Mg radiophotoluminescence films in charged particle beams

Auteurs: Marijke De Saint-Hubert, Fabio Castellano, Paul Leblans, Paul Sterckx, Satoshi Kodaira, Jan Swakoń, Luana de Freitas Nascimento
Publié dans: Radiation Measurements, Numéro 141, 2021, Page(s) 106518, ISSN 1350-4487
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.radmeas.2021.106518

Water Equivalence of Various 3D Printed Materials for Proton Therapy --- Monte Carlo Simulation, Treatment Planning Modelling and Validation by Measurements

Auteurs: A. Wochnik, J. Swakoń, P. Olko
Publié dans: Acta Physica Polonica B, Numéro 51/1, 2020, Page(s) 409, ISSN 0587-4254
Éditeur: Jagellonian University
DOI: 10.5506/aphyspolb.51.409

Out-of-field doses for scanning proton radiotherapy of shallowly located paediatric tumours—a comparison of range shifter and 3D printed compensator

Auteurs: A Wochnik, L Stolarczyk, I Ambrožová, M Davídková, M De Saint-Hubert, S Domański, C Domingo, Ž Knežević, R Kopeć, M Kuć, M Majer, N Mojżeszek, V Mares, I Martínez-Rovira, M Á Caballero-Pacheco, E Pyszka, J Swakoń, S Trinkl, M Tisi, R Harrison, P Olko
Publié dans: Physics in Medicine & Biology, Numéro 66/3, 2021, Page(s) 035012, ISSN 0031-9155
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6560/abcb1f

First experimental measurements of 2D microdosimetry maps in proton therapy

Auteurs: Consuelo Guardiola, Diana Bachiller-Perea, Emmanuel M. Mate Kole, Celeste Fleta, David Quirion, Ludovic De Marzi, Faustino Gómez
Publié dans: European Journal of Medical Physics, Numéro Vol 50, Numéro 1, 2022, ISSN 2473-4209
Éditeur: Physica Medica
DOI: 10.1002/mp.15945

Tumour irradiation in mice with a laser-accelerated proton beam

Auteurs: Florian Kroll, Florian-Emanuel Brack, Constantin Bernert, Stefan Bock, Elisabeth Bodenstein, Kerstin Brüchner, Thomas E Cowan, Lennart Gaus, René Gebhardt, Uwe Helbig, Leonhard Karsch, Thomas Kluge, Stephan Kraft, Mechthild Krause, Elisabeth Lessmann, Umar Masood, Sebastian Meister, Josefine Metzkes-Ng, Alexej Nossula, Jörg Pawelke, Jens Pietzsch, Thomas Püschel, Marvin Reimold, Martin Rehwald
Publié dans: Nature Physics, 2022, Page(s) 316-322, ISSN 1745-2473
Éditeur: Nature Publishing Group
DOI: 10.1038/s41567-022-01520-3

Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?

Auteurs: Sébastien Penninckx, Félicien Hespeels, Julien Smeets, Julien L. Colaux, Stéphane Lucas and Anne-Catherine Heuskin
Publié dans: Radiation and Its Application in Oncology and Radiation Protection, 2021, ISSN 2673-592X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/radiation1040025

Does FLASH deplete oxygen? Experimental evaluation for photons, protons, and carbon ions

Auteurs: Jeannette Jansen, Jan Knoll, Elke Beyreuther, Jörg Pawelke, Raphael Skuza, Rachel Hanley, Stephan Brons, Francesca Pagliari, Joao Seco
Publié dans: Medical Physics, 2021, Page(s) 3982-3990, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.14917

Beam Monitor Calibration for Radiobiological Experiments With Scanned High Energy Heavy Ion Beams at FAIR

Auteurs: Francesca Luoni; Francesca Luoni; Uli Weber; Daria Boscolo; Marco Durante; Marco Durante; Claire-Anne Reidel; Claire-Anne Reidel; Christoph Schuy; Klemens Zink; Klemens Zink; Felix Horst; Felix Horst
Publié dans: Frontiers in physics 8, 568145 (2020). doi:10.3389/fphy.2020.568145, Numéro 13, 2020, ISSN 2296-424X
Éditeur: Springer
DOI: 10.15120/gsi-2020-01146

Validation of a pseudo-3D phantom for radiobiological treatment plan verifications

Auteurs: D A Kartini, O Sokol, J Wiedemann, W Tinganelli, M Witt, G Camazzola, M Krämer, C Talabnin, C Kobdaj, M C Fuss
Publié dans: Physics in Medicine & Biology, Numéro 65/22, 2020, Page(s) 225039, ISSN 1361-6560
Éditeur: IOP Science
DOI: 10.1088/1361-6560/abb92d

Particle therapy in Europe

Auteurs: Cai Grau, Marco Durante, Dietmar Georg, Johannes A. Langendijk, Damien C. Weber
Publié dans: Molecular Oncology, Numéro 14/7, 2020, Page(s) 1492-1499, ISSN 1574-7891
Éditeur: Elsevier BV
DOI: 10.1002/1878-0261.12677

Nanomaterials as Ultrasound Theragnostic Tools for Heart Disease Treatment/Diagnosis

Auteurs: Edouard Alphandéry
Publié dans: Theranostic Ultrasound Contrast Agents in Medical Applications, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031683

OC-0563 First experience with the model-based selection of head and neck cancer patients for proton therapy

Auteurs: M. Tambas, H.P. Van der Laan, J.G.M. Van den Hoek, H.P. Bijl, M. Dieters, R.G.J. Kierkels, D. Scandurra, S. Both, R.J.H.M. Steenbakkers, J.A. Langendijk
Publié dans: Radiotherapy and Oncology, Numéro 133, 2019, Page(s) S293-S294, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/s0167-8140(19)30983-1

A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy

Auteurs: Miriam Krieger, Steven van de Water, Michael M. Folkerts, Alejandro Mazal, Silvia Fabiano, Nicola Bizzocchi, Damien C. Weber, Sairos Safai, Antony J. Lomax
Publié dans: Medical Physics, Numéro Vol 49, Numéro 3, 2022, Page(s) 2026-2038, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.15459

Proposing a Clinical Model for RBE Based on Proton Track-End Counts

Auteurs: Nicholas T. Henthorn, Lydia L. Gardner, Adam H. Aitkenhead, Benjamin C. Rowland, Jungwook Shin, Edward A.K. Smith, Michael J. Merchant, Ranald I. Mackay, Karen J. Kirkby, Pankaj Chaudhary, Kevin M. Prise, Stephen J. McMahon, Tracy S.A. Underwood,
Publié dans: International Journal of Radiation Oncology, Numéro Vol 115, Numéro 3, 2023, ISSN 0000-0000
Éditeur: Red Journel
DOI: 10.1016/j.ijrobp.2022.12.056

Influence of Therapeutic Proton Beam on Glioblastoma Multiforme Proliferation Index — A Preliminary Study

Auteurs: A.M. Bogdali-Suślik, K. Rawojć, J. Miszczyk, A. Panek, M. Woźniak, K. Szewczyk, T. Książek, M. Bik-Multanowski, J. Swakoń, W. Komenda, N. Mojżeszek, T. Kajdrowicz, R. Kopeć, P. Olko
Publié dans: Acta Physica Polonica A, Numéro 137/1, 2020, Page(s) 64-69, ISSN 0587-4246
Éditeur: Polska Akademia Nauk
DOI: 10.12693/aphyspola.137.64

Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer

Auteurs: Marta Lazzeroni, Ana Ureba, Nicole Wiedenmann, Nils H. Nicolay, Michael Mix, Benedikt Thomann, Dimos Baltas, Iuliana Toma-Dasu, Anca L. Grosu
Publié dans: Physics and Imaging in Radiation Oncology, Numéro 17, 2021, Page(s) 100-105, ISSN 2405-6316
Éditeur: Elsevier
DOI: 10.1016/j.phro.2021.01.011

First experience with model-based selection of head and neck cancer patients for proton therapy

Auteurs: Makbule Tambas, Roel J.H.M. Steenbakkers, Hans P. van der Laan, Atje M. Wolters, Roel G.J. Kierkels, Dan Scandurra, Erik W. Korevaar, Edwin Oldehinkel, Tineke W.H. van Zon-Meijer, Stefan Both, Johanna G.M. van den Hoek, Johannes A. Langendijk
Publié dans: Radiotherapy and Oncology, Numéro 151, 2020, Page(s) 206-213, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2020.07.056

Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates

Auteurs: Steven van de Water, Sairos Safai, Jacobus M. Schippers, Damien C. Weber, Antony J. Lomax
Publié dans: Acta Oncologica, Numéro 58/10, 2019, Page(s) 1463-1469, ISSN 0284-186X
Éditeur: Taylor & Francis
DOI: 10.1080/0284186x.2019.1627416

Insights into the non-homologous end joining pathway and double strand break end mobility provided by mechanistic in silico modelling

Auteurs: John W. Warmenhoven, Nicholas T. Henthorn, Samuel P. Ingram, Amy L. Chadwick, Marios Sotiropoulos, Nickolay Korabel, Sergei Fedotov, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publié dans: DNA Repair, Numéro 85, 2020, Page(s) 102743, ISSN 1568-7864
Éditeur: Elsevier BV
DOI: 10.1016/j.dnarep.2019.102743

The European Joint Research Project UHDpulse - Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates.

Auteurs: Andreas Schüller; Sophie Heinrich; Charles Fouillade; Anna Subiel; Ludovic De Marzi; Francesco Romano; Francesco Romano; Peter Peier; Maria A Trachsel; Celeste Fleta; Rafael Kranzer; Marco Caresana; S. Salvador; Simon Busold; Andreas A. Schönfeld; Malcolm McEwen; Faustino Gómez; Jaroslav Solc; Claude Bailat; Vladimír Linhart; J. Jakubek; Jörg Pawelke; Jörg Pawelke; Marco Borghesi; Ralf-Peter
Publié dans: "Physica Medica, Elsevier, 2020, 80, pp.134-150. ⟨10.1016/j.ejmp.2020.09.020⟩", Numéro 1, 2020, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2020.09.020

Current practice in proton therapy delivery in adult cancer patients across Europe

Auteurs: Makbule Tambas; Hans Paul van der Laan; Roel J.H.M. Steenbakkers; Jerome Doyen; Beate Timmermann; Ester Orlandi; Morten Hoyer; Karin Haustermans; Petra Georg; Neil G Burnet; Vincent Gregoire; Valentin Calugaru; Esther G.C. Troost; Frank Hoebers; Felipe A. Calvo; Joachim Widder; Fabian Eberle; Marco van Vulpen; Philippe Maingon; Tomasz Skóra; Damien C. Weber; Kjell Bergfeldt; Jiri Kubes; Johannes
Publié dans: Radiotherapy and Oncology, 167, 7 - 13. Elsevier Ireland Ltd, Numéro 1, 2022, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2021.12.004

In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH

Auteurs: Brita Singers Sørensen, Mateusz Krzysztof Sitarz, Christina Ankjærgaard, Jacob Johansen, Claus E Andersen, Eleni Kanouta, Cathrine Overgaard, Cai Grau, Per Poulsen
Publié dans: Radiotherapy and Oncology, Numéro 167, 2022, Page(s) 109-155, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2021.12.022

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

Auteurs: Iñaki Schniewind, Wahyu Wijaya Hadiwikarta, JuliaGrajek, Jan Poleszczuk, Susan Richter, Mirko Peitzsch, Johannes Müller, Daria Klusa, Elke Beyreuther, Steffen Löck, Armin Lühr, Susanne Frosch, Christer Groeben, Ulrich Sommer, Mechthild Krause, Anna Dubrovska, Cläre von Neubeck, Ina Kurth, Claudia Peitzsch
Publié dans: Cell Reports, Numéro Volume 38 Numéro 8, 2022, ISSN 0000-0000
Éditeur: Science Direct - Elsevier
DOI: 10.1016/j.celrep.2022.110422

Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: a European multi-centric study

Auteurs: Hahn C, Ödén J, Dasu A, Vestergaard A, Fuglsang Jensen M, Sokol O, Pardi C, Bourhaleb F, Leite A, de Marzi L, Smith E, Aitkenhead A, Rose C, Merchant M, Kirkby K, Grzanka L, Pawelke J, Lühr A
Publié dans: Acta Oncol, Numéro 0284186X, 2022, Page(s) 206-214, ISSN 0284-186X
Éditeur: Taylor & Francis
DOI: 10.1080/0284186x.2021.1992007

In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept

Auteurs: Edward A. K. Smith, N. T. Henthorn, J. W. Warmenhoven, S. P. Ingram, A. H. Aitkenhead, J. C. Richardson, P. Sitch, A. L. Chadwick, T. S. A. Underwood, M. J. Merchant, N. G. Burnet, N. F. Kirkby, K. J. Kirkby, R. I. Mackay
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-56258-5

Conference proceedings (16)

The Effect of Ionizing Radiation on MCF-7 Breast Cancer Cell Line

Auteurs: Agnė Bartnykaitė, Rasa Ugenskienė, Arturas Inčiūra, Elona Juozaitytė
Publié dans: 2020
Éditeur: LSMU

Patient-specific 3D printed compensators for proton pencil beam scanning of shallow situated tumours

Auteurs: A. Wochnik, T. Kajdrowicz, J. Swakoń, E. Kieres, W. Komenda, R. Kopeć, D. Krzempek, M. Liszka, B. Michalec, G. Mierzwińska, A. Pędracka, M. Rydygier, K. Skowrońska, U. Sowa, P. Wrzesińska and P. Olko
Publié dans: 2018
Éditeur: ENLIGHT

Optimization of Preselection Process in Model-based Selection for Proton Therapy in Head & Neck Cancer

Auteurs: M. Tambas, J.G.M. van den Hoek, R.G.J. Kierkels, D. Scandurra, A.M. Wolters, D. Mulder, E. Oldehinkel, T. van Zon-Meijer, S. Both, R.J.H.M. Steenbakkers, J.A. Langendijk
Publié dans: ESTRO2020, 2020
Éditeur: ESTRO

Flash modalities track (oral presentations) flat panel proton radiography in high-precision image-guided mouse brain proton irradiation

Auteurs: E. Bodenstein, E. Beyreuther, J. Bock, A. Dietrich, J. Pawelke, M. Schürer, T. Suckert, J. Müller, A. Lühr
Publié dans: Physica Medica, 2022, Page(s) S56-S57, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01561-7

Spatially fractionated proton therapy of eye cancer: Feasibility studies

Auteurs: A. Toboła-Galus, P. Olko, J. Swakoń
Publié dans: Physica Medica, 2022, Page(s) S50, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01545-9

INSPIRE: Infrastructure in proton international research – A new horizon 2020 network

Auteurs: Stine Korreman
Publié dans: Physica Medica, 2018, Page(s) 24, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2018.06.130

Modelling framework for FMISO and FDG PET imaging tailored dose prescription

Auteurs: M. Lazzeroni, A. Ureba, D. Baltas, A. L. Grosu, I. Toma-Dasu
Publié dans: ESTRO38, 2019
Éditeur: ESTRO38

In vitro measurements of proton rbe: a multi-centric comparison of experimental procedures and results

Auteurs: O.SokolN.HenthornE.SantinaK.KirkbyM.DavídkováA.MichaelidesováO.ZahradníčekA. MaiaLeiteL.De MarziF.PouzouletB.OrzechowskaJ.MiszczykP.OlkoA.DasuB.StenerlöwS.BrandenburgM.J.Van GoethemR.P.CoppesM.SitarzB.Sørensen…M.Durante
Publié dans: European Journal of Medical Physics, Numéro S57-S58, 2022, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01563-0

Protontherapy Therapeutic Window Widening By Pbct And Flash Modalities - Epd020

Auteurs: Pavel Bláha, Lorenzo Manti, Ludovic de Marzi, Frédérique Mégnin-Chanet, Amélia Maia Leite, Annalisa Patriarca, Valerio Ricciardi, Katarína Michaličková
Publié dans: European Journal of Medical Physics, 2022, ISSN 1120-1797
Éditeur: Physica Medica
DOI: 10.1016/s1120-1797(22)01591-5

FLASH Modalities Track (Oral Presentations) SPECTRAL- AND INTENSITY-SENSITIVE CHARACTERIZATION OF PULSED FLASH PROTON FIELDS WITH THE PIXEL DETECTOR TIMEPIX3

Auteurs: C. Oancea E. Bodenstein C. Granja J. Jakubek L. Marek J. Pawelke J. Pivec S. Polansky J. Šolc
Publié dans: Physics Medica, European Journal of Medical Physics, 2022, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01565-4

Dosimetry of primary beam and scattered radiation in proton therapy

Auteurs: Pawel Olko
Publié dans: IFJ Pan, 2020
Éditeur: IFJ Pan

Flash modalities track (oral presentations) ultra-high dose rate beam monitoring and control for a varian probeam system

Auteurs: S.BusoldM.SchedlerT.FelderI.HuthJ.Heese
Publié dans: Physica Medica, 2022, Page(s) S56, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01560-5

Does FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions

Auteurs: Jansen, Jeannette; Knoll, Jan; Beyreuther, Elke; Pawelke, Jörg; Skuza, Raphael; Hanley, Rachel; Brons, Stephan; Pagliari, Francesca; Seco, Joao
Publié dans: Numéro 3, 2021
Éditeur: Cornell University

Using Comprehensive Relative-Biological-Effectiveness Simulations to Assess the Potential Clinical Gain of FLASH Proton Therapy

Auteurs: S van de Water, S Fabiano, N Bizzocchi, S Safai, D Weber, A Mazal, J Unkelbach, A Lomax
Publié dans: 2020 Joint APPM/Comp Meeting, 2020
Éditeur: APPM

An ion chamber array for easy assessment of flash proton fields

Auteurs: L.StolarczykM.SitarzI.HuthP.PoulsenT.Pfeiler
Publié dans: Physica Medica, 2022, Page(s) S79, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01613-1

Flash modalities track (oral presentations) preliminary results of dosimetry audit of active scanning proton beam

Auteurs: M. Davídková, A. Dasu, C. De Angelis, L. De Marzi, M. De Saint-Hubert, D. Ekendahl, A. Jelínek Michaelidesová, Ž. Knežević, P. Kukolowicz, M. Liszka, S. Lorentini, A. Maia Leite, M. Majer, B. Michalec, M. Navrátil, B. Reniers, M.J. Van Goethem, A. Vestergaard, G. Vilches-Freixas, V. Vondráček, L. Stolarczyk, P. Olko
Publié dans: Physica Medica, 2022, Page(s) S57, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01562-9

Book chapters (1)

Assessment of the Probability of Tumour Control for Prescribed Doses Based on Imaging of Oxygen Partial Pressure

Auteurs: Ana Ureba, Emely Kjellsson Lindblom, Iuliana Toma-Dasu, Alexandru Dasu, Marta Lazzeroni
Publié dans: Oxygen Transport to Tissue XLII, Numéro 1269, 2021, Page(s) 185-190, ISBN 978-3-030-48236-7
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-48238-1_29

Other (4)

Extending of the pytrip software package for biologically optimized proton radiotherapy

Auteurs: Leszek Grzanka, Kinga Jeleń1, Łukasz Jeleń, Arkadiusz Ćwikła, Michał Krawczyk, Joanna Fortuna, Mateusz Łaszczyk, Paweł Olko
Publié dans: 2021
Éditeur: The Henryk Niewodniczański INSTITUTE OF NUCLEAR PHYSICS Polish Academy of Sciences

An In Silico Model of DNA Repair for Investigation of Mechanisms in Non-Homologous End Joining

Auteurs: Ranald I Mackay; Nicholas T. Henthorn; Marios Sotiropoulos; J.W. Warmenhoven; Karen J. Kirkby; Sergei Fedotov; Michael J. Merchant; Nickolay Korabel
Publié dans: Numéro 1, 2018
Éditeur: bioRxiv
DOI: 10.1101/318139

Towards incorporation of RBE uncertainty in proton therapy planning systems

Auteurs: Leszek Grzanka , Kinga Jeleń, Michael P.R. Waligórski
Publié dans: 2019
Éditeur: The Henryk Niewodniczański INSTITUTE OF NUCLEAR PHYSICS Polish Academy of Sciences

An Industry/Academic Partnership Yields Fruit: An Ultra-High Dose Rate Beam Monitoring Tool for FLASH Trials

Auteurs: Varian Medical Systems, Inc.
Publié dans: 2021
Éditeur: 12

Thesis and dissertations (1)

Cell responses to ionizing radiation: current research at Lithuania University of Health Sciences and future perspectives with “Inspire” project

Auteurs: Juozaitytė, Elona;Bartnykaitė, Agnė;Laukaitienė, Danguolė;Ugenskienė, Rasa
Publié dans: Rīga Stradiņš University International conference on Medical and Health Care Sciences, Numéro Knowledge for Use in Practice: abstracts, 2019, Page(s) Conference Section Oncology and Haematology
Éditeur: Rīga Stradiņš University

Droits de propriété intellectuelle

Patent (2)

Method of obtaining a system containing gold nanomolecules and application of such system in anticancer therapy

Numéro de demande/publication: 43 199619
Date: 2019-11-28

DEVICE FOR CONTAINING ANIMALS DURING IRRADIATION BY A PROTON BEAM

Numéro de demande/publication: 20 22065951
Date: 2022-06-13
Demandeur(s): UNIVERSITE DE NAMUR ASBL