Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research

Resultado final

Long-term strategic outreach plan for both academic and industry users including a training plan
Standardized work-flows for integrative sample preparation methods for structural biology in cells
Process plan for raw and metadata archiving in subtask 8.1.2
Prototype process for data transfer defined in subtask 8.1.1
Plan a programme for review of Instruct infrastructure with external review panel
Process for establishing joint activities with new countries and formalising an agreement defining the shared programme
Training programme for core facility and Instruct Centre staff
Dissemination, outreach and exploitation plan submitted to Executive Committee for review
Standardized work-flows for extending the use of nanobodies
Public list of services offered to industries
Standardized work-flows for production, crystallization and data collection of membrane protein
Publication of a position paper on the operation of NMR services and RIs in general as a guide for users in collaboration with WP3
Schedule of events to engage widely with key stakeholders

Implemented software package for remote access EM data
VLE final version available to public
Develop enhanced deposition of structural data to databases
Call 1 launched for developing new service provision of existing technologies and selection of qualifying projects

Women in Science workshop
Outreach programme for new academic communities including an information pack
Information campaign addressing SMEs

Publicaciones

Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data

Autores: Deepansh J. Srivastava, Thomas Vosegaard, Dominique Massiot, Philip J. Grandinetti
Publicado en: PLOS ONE, Edición 15/1, 2020, Página(s) e0225953, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0225953

Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sites

Autores: Shruthi Sridhar, Werner Schmitz, J. Kalervo Hiltunen, Rajaram Venkatesan, Ulrich Bergmann, Tiila-Riikka Kiema, Rikkert K. Wierenga
Publicado en: Acta Crystallographica Section D Structural Biology, Edición 76/12, 2020, Página(s) 1256-1269, ISSN 2059-7983
Editor: International Union of Crystallography
DOI: 10.1107/s2059798320013819

Real-Time Quantitative In-Cell NMR: Ligand Binding and Protein Oxidation Monitored in Human Cells Using Multivariate Curve Resolution

Autores: Enrico Luchinat, Letizia Barbieri, Timothy F. Campbell, Lucia Banci
Publicado en: Analytical Chemistry, Edición 92/14, 2020, Página(s) 9997-10006, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.0c01677

Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency

Autores: Enrico Luchinat, Letizia Barbieri, Matteo Cremonini, Alessio Nocentini, Claudiu T. Supuran, Lucia Banci
Publicado en: Angewandte Chemie International Edition, Edición 59/16, 2020, Página(s) 6535-6539, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201913436

Improvements on marker-free images alignment for electron tomography

Autores: C.O.S. Sorzano, F. de Isidro-Gómez, E. Fernández-Giménez, D. Herreros, S. Marco, J.M. Carazo, C. Messaoudi
Publicado en: Journal of Structural Biology: X, Edición 4, 2020, Página(s) 100037, ISSN 2590-1524
Editor: Elsevier
DOI: 10.1016/j.yjsbx.2020.100037

Automatic local resolution-based sharpening of cryo-EM maps

Autores: Erney Ramírez-Aportela, Jose Luis Vilas, Alisa Glukhova, Roberto Melero, Pablo Conesa, Marta Martínez, David Maluenda, Javier Mota, Amaya Jiménez, Javier Vargas, Roberto Marabini, Patrick M Sexton, Jose Maria Carazo, Carlos Oscar S Sorzano
Publicado en: Bioinformatics, 2019, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btz671

Mechanistic Investigations of Green mEos4b Reveal a Dynamic Long-Lived Dark State

Autores: Elke De Zitter, Jacqueline Ridard, Daniel Thédié, Virgile Adam, Bernard Lévy, Martin Byrdin, Guillaume Gotthard, Luc Van Meervelt, Peter Dedecker, Isabelle Demachy, Dominique Bourgeois
Publicado en: Journal of the American Chemical Society, Edición 142/25, 2020, Página(s) 10978-10988, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c01880

Spectral editing of intra- and inter-chain methyl–methyl NOEs in protein complexes

Autores: Ricarda Törner, Rida Awad, Pierre Gans, Bernhard Brutscher & Jerome Boisbouvier
Publicado en: Journal of Biomolecular NMR, 2020, ISSN 1573-5001
Editor: Springer Nature
DOI: 10.1007/s10858-019-00293-x

MicrographCleaner: A python package for cryo-EM micrograph cleaning using deep learning

Autores: Ruben Sanchez-Garcia, Joan Segura, David Maluenda, C.O.S. Sorzano, J.M. Carazo
Publicado en: Journal of Structural Biology, Edición 210/3, 2020, Página(s) 107498, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2020.107498

Stabilizing the Closed SARS-CoV-2 Spike Trimer

Autores: Jarek Juraszek, Lucy Rutten, Sven Blokland, Pascale Bouchier, Richard Voorzaat, Tina Ritschel, Mark J.G. Bakkers, Ludovic L.R. Renault, Johannes P.M. Langedijk
Publicado en: bioRxiv, 2020, ISSN 0000-0000
Editor: bioRxiv
DOI: 10.1101/2020.07.10.197814

Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis

Autores: Yong Zi Tan, José Rodrigues, James E. Keener, Ruixiang Blake Zheng, Richard Brunton, Brian Kloss, Sabrina I. Giacometti, Ana L. Rosário, Lei Zhang, Michael Niederweis, Oliver B. Clarke, Todd L. Lowary, Michael T. Marty, Margarida Archer, Clinton S. Potter, Bridget Carragher, Filippo Mancia
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17202-8

Mixing Aβ(1–40) and Aβ(1–42) peptides generates unique amyloid fibrils

Autores: Linda Cerofolini, Enrico Ravera, Sara Bologna, Thomas Wiglenda, Annett Böddrich, Bettina Purfürst, Iryna Benilova, Magdalena Korsak, Gianluca Gallo, Domenico Rizzo, Leonardo Gonnelli, Marco Fragai, Bart De Strooper, Erich E. Wanker, Claudio Luchinat
Publicado en: Chemical Communications, Edición 56/62, 2020, Página(s) 8830-8833, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d0cc02463e

Advanced isotopic labeling for the NMR investigation of challenging proteins and nucleic acids

Autores: Jerome Boisbouvier, Lewis E. Kay
Publicado en: Journal of Biomolecular NMR, Edición 71/3, 2018, Página(s) 115-117, ISSN 0925-2738
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0199-9

Fast simulations of multidimensional NMR spectra of proteins and peptides

Autores: Thomas Vosegaard
Publicado en: Magnetic Resonance in Chemistry, Edición 56/6, 2018, Página(s) 438-448, ISSN 0749-1581
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mrc.4663

Volta phase plate data collection facilitates image processing and cryo-EM structure determination

Autores: Ottilie von Loeffelholz, Gabor Papai, Radostin Danev, Alexander G. Myasnikov, S. Kundhavai Natchiar, Isabelle Hazemann, Jean-François Ménétret, Bruno P. Klaholz
Publicado en: Journal of Structural Biology, Edición 202/3, 2018, Página(s) 191-199, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2018.01.003

Visualization of chemical modifications in the human 80S ribosome structure

Autores: S. Kundhavai Natchiar, Alexander G. Myasnikov, Hanna Kratzat, Isabelle Hazemann, Bruno P. Klaholz
Publicado en: Nature, 2017, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature24482

Function and Interactions of ERCC1-XPF in DNA Damage Response

Autores: Maryam Faridounnia, Gert Folkers, Rolf Boelens
Publicado en: Molecules, Edición 23/12, 2018, Página(s) 3205, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23123205

Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions

Autores: Linda Cerofolini, Stefano Giuntini, Letizia Barbieri, Matteo Pennestri, Anna Codina, Marco Fragai, Lucia Banci, Enrico Luchinat, Enrico Ravera
Publicado en: Biophysical Journal, Edición 116/2, 2019, Página(s) 239-247, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2018.11.3132

Validation of electron microscopy initial models via small angle X-ray scattering curves

Autores: Amaya Jiménez, Slavica Jonic, Tomas Majtner, Joaquín Otón, Jose Luis Vilas, David Maluenda, Javier Mota, Erney Ramírez-Aportela, Marta Martínez, Yaiza Rancel, Joan Segura, Ruben Sánchez-García, Roberto Melero, Laura del Cano, Pablo Conesa, Lars Skjaerven, Roberto Marabini, Jose M Carazo, Carlos Oscar S Sorzano
Publicado en: Bioinformatics, Edición 35/14, 2018, Página(s) 2427-2433, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/bty985

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

Autores: Haitian Fan, Alexander P. Walker, Loïc Carrique, Jeremy R. Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, Jonathan M. Grimes, Ervin Fodor
Publicado en: Nature, Edición 573/7773, 2019, Página(s) 287-290, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1530-7

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

Autores: Leonid Andronov, Khalid Ouararhni, Isabelle Stoll, Bruno P. Klaholz, Ali Hamiche
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-12383-3

Deriving and refining atomic models in crystallography and cryo-EM: the latest Phenix tools to facilitate structure analysis

Autores: Bruno P. Klaholz
Publicado en: Acta Crystallographica Section D Structural Biology, Edición 75/10, 2019, Página(s) 878-881, ISSN 2059-7983
Editor: IUCr/Wiley
DOI: 10.1107/s2059798319013391

Flexible workflows for on-the-fly electron-microscopy single-particle image processing using Scipion

Autores: D. Maluenda, T. Majtner, P. Horvath, J. L. Vilas, A. Jiménez-Moreno, J. Mota, E. Ramírez-Aportela, R. Sánchez-García, P. Conesa, L. del Caño, Y. Rancel, Y. Fonseca, M. Martínez, G. Sharov, C.A. García, D. Strelak, R. Melero, R. Marabini, J. M. Carazo, C. O. S. Sorzano
Publicado en: Acta Crystallographica Section D Structural Biology, Edición 75/10, 2019, Página(s) 882-894, ISSN 2059-7983
Editor: IUCr/Wiley
DOI: 10.1107/s2059798319011860

DeepRes : a new deep-learning- and aspect-based local resolution method for electron-microscopy maps

Autores: Erney Ramírez-Aportela, Javier Mota, Pablo Conesa, Jose Maria Carazo, Carlos Oscar S. Sorzano
Publicado en: IUCrJ, Edición 6/6, 2019, Página(s) 1054-1063, ISSN 2052-2525
Editor: IUCr
DOI: 10.1107/s2052252519011692

On the complementarity of X-ray and NMR data

Autores: Antonio Schirò, Azzurra Carlon, Giacomo Parigi, Garib Murshudov, Vito Calderone, Enrico Ravera, Claudio Luchinat
Publicado en: Journal of Structural Biology: X, Edición 4, 2020, Página(s) 100019, ISSN 2590-1524
Editor: Elsevier
DOI: 10.1016/j.yjsbx.2020.100019

FlexAlign: An Accurate and Fast Algorithm for Movie Alignment in Cryo-Electron Microscopy

Autores: David Střelák, Jiří Filipovič, Amaya Jiménez-Moreno, Jose Carazo, Carlos Sánchez Sorzano
Publicado en: Electronics, Edición 9/6, 2020, Página(s) 1040, ISSN 2079-9292
Editor: MDPI
DOI: 10.3390/electronics9061040

Towards a European health research and innovation cloud (HRIC)

Autores: F. M. Aarestrup, A. Albeyatti, W. J. Armitage, C. Auffray, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie, M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. L
Publicado en: Genome Medicine, Edición 12/1, 2020, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-020-0713-z

Different flavors of diffusion in paramagnetic systems: Unexpected NMR signal intensity and relaxation enhancements

Autores: Enrico Ravera, Marco Fragai, Giacomo Parigi, Claudio Luchinat
Publicado en: Journal of Magnetic Resonance Open, Edición 2-3, 2020, Página(s) 100003, ISSN 2666-4410
Editor: Elsevier
DOI: 10.1016/j.jmro.2020.100003

Solution of a Puzzle: High-Level Quantum-Chemical Treatment of Pseudocontact Chemical Shifts Confirms Classic Semiempirical Theory

Autores: Lucas Lang, Enrico Ravera, Giacomo Parigi, Claudio Luchinat, Frank Neese
Publicado en: The Journal of Physical Chemistry Letters, Edición 11/20, 2020, Página(s) 8735-8744, ISSN 1948-7185
Editor: American Chemical Society
DOI: 10.1021/acs.jpclett.0c02462

Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures

Autores: Roberto Melero, Carlos Oscar S. Sorzano, Brent Foster, José-Luis Vilas, Marta Martínez, Roberto Marabini, Erney Ramírez-Aportela, Ruben Sanchez-Garcia, David Herreros, Laura del Caño, Patricia Losana, Yunior C. Fonseca-Reyna, Pablo Conesa, Daniel Wrapp, Pablo Chacon, Jason S. McLellan, Hemant D. Tagare, Jose-Maria Carazo
Publicado en: IUCrJ, Edición 7/6, 2020, Página(s) 1059-1069, ISSN 2052-2525
Editor: International Union of Crystallography
DOI: 10.1107/s2052252520012725

Measurement of local resolution in electron tomography

Autores: J.L. Vilas, J. Oton, C. Messaoudi, R. Melero, P. Conesa, E. Ramirez-Aportela, J. Mota, M. Martinez, A. Jimenez, R. Marabini, J.M. Carazo, J. Vargas, C.O.S. Sorzano
Publicado en: Journal of Structural Biology: X, Edición 4, 2020, Página(s) 100016, ISSN 2590-1524
Editor: Elsevier
DOI: 10.1016/j.yjsbx.2019.100016

Multitarget Virtual Screening for Drug Repurposing in COVID19

Autores: carlos oscar Sorzano; Enrique Crisman; Jose Maria Carazo; rafael leon
Publicado en: Chemrxiv, Edición 2, 2020, ISSN 2573-2293
Editor: Chemrxiv
DOI: 10.26434/chemrxiv.12652997

A Topological Switch Enables Misfolding of the Cystic Fibrosis Transmembrane Conductance Regulator

Autores: Daniel Scholl
Publicado en: bioRxiv, 2020, ISSN 0000-0000
Editor: Biorxiv
DOI: 10.1101/2020.07.09.195099

FSC-Q: A CryoEM map-to-atomic model quality

Autores: Ramírez-Aportela E, Maluenda D, Fonseca YC, Conesa P, Marabini R, Heymann JB, Carazo JM, Sorzano COS
Publicado en: BioRxiv, 2020, ISSN 2052-2525
Editor: BioRxiv
DOI: 10.1101/2020.05.12.069831

Instruct-ULTRA D1.4 Dissemination, outreach and exploitation plan submitted to Executive Committee for review.

Autores: Gray, Naomi; Owens, Ray
Publicado en: Edición 1, 2017
Editor: Zenodo
DOI: 10.5281/zenodo.4304625

Instruct-ULTRA D3.3 Process for establishing joint activities with new countries and formalising an agreement defining the shared programme

Autores: Owens, Ray; Gray, Naomi
Publicado en: Edición 8, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311654

Instruct-ULTRA D5.3 Information campaign addressing SMEs

Autores: Chapman, Stephanie; Gray, Naomi; Morelli, Francesca; Owens, Ray
Publicado en: Edición 1, 2021
Editor: Zenodo
DOI: 10.5281/zenodo.4428101

Instruct-ULTRA D1.3 Women in Science Workshop

Autores: Chrysina, Evangelia; Gray, Naomi; Chapman, Stephanie
Publicado en: Edición 3, 2019
Editor: Zenodo
DOI: 10.5281/zenodo.4304571

Instruct-ULTRA D2.4 Schedule of events to engage widely with key stakeholders

Autores: Chapman, Stephanie; Gray, Naomi; Owens, Ray
Publicado en: Edición 1, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4304649

Instruct-ULTRA D7.2 Standardised workflows for integrative sample preparation methods for structural biology in cells

Autores: Hart, Darren; Poterszman, Arnaud; van Ingen, Hugo; Boisbouvier, Jerome; Luchinat, Enrico
Publicado en: Edición 5, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311800

Instruct-ULTRA D5.5 Outreach programme for new academic communities including an information pack

Autores: Gray, Naomi; Owens, Ray
Publicado en: Edición 1, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311775

Instruct-ULTRA D2.1 Plan a programme for review of Instruct Infrastructure with external review panel.

Autores: Owens, Ray
Publicado en: Edición 1, 2018
Editor: Zenodo
DOI: 10.5281/zenodo.4304627

Instruct-ULTRA D6.2 VLE final version available to public

Autores: Gray, Naomi; Chapman, Marysa; Perrakis, Anastassis
Publicado en: Edición 2, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311781

Instruct-ULTRA D8.2 Process plan for raw and metadata archiving in subtask 8.1.2

Autores: Smith, Neil; Carazo, Jose Maria
Publicado en: Edición 12, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311808

Instruct-ULTRA D5.3 Information campaign addressing SMEs

Autores: Chapman, Stephanie; Gray, Naomi; Owens, Ray
Publicado en: Edición 9, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311758

Instruct-ULTRA D5.4 Long-Term Strategic Outreach Plan for both academic and industry users, including a training plan

Autores: Owens, Ray; Daenke, Susan; Chapman, Stephanie; Gray, Naomi; Morelli, Francesca
Publicado en: Edición 3, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4317039

Instruct-ULTRA D1.2 Training programme for core facility and Instruct Centre staff

Autores: Gray, Naomi; Chapman, Stephanie
Publicado en: Edición 3, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4304525

Instruct-ULTRA D8.1 Prototype process for data transfer defined in subtask 8.1.1

Autores: Del Cano, Laura; White, Alex; Ashton, Alun; Smith, Neil; Carazo, Jose Maria
Publicado en: Edición 3, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311804

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Autores: Tomasz Uchański, Simonas Masiulis, Baptiste Fischer, Valentina Kalichuk, Alexandre Wohlkönig, Thomas Zögg, Han Remaut, Wim Vranken, A. Radu Aricescu, Els Pardon, Jan Steyaert
Publicado en: bioRxiv, 2019
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/812230

MicrographCleaner: a python package for cryo-EM micrograph segmentation using deep learning.

Autores: Sanchez-Garcia R, Segura J, Maluenda D, Sorzano CO, Carazo JM.
Publicado en: bioRxiv, 2019
Editor: Cold Spring Harbor Laboratory

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.

Autores: Uchanski T, Masiulis S, Fischer B, Kalichuk V, Wohlkonig A, Zogg T, Remaut H, Vranken W, Aricescu AR, Pardon E, Steyaert J.
Publicado en: bioRxiv, 2019
Editor: Cold Spring Harbor Laboratory

Instruct-ULTRA D5.1 Public list of services offered to industries

Autores: Banci, Lucia; Morelli, Francesca; Pierattelli, Roberta; Gray, Naomi
Publicado en: Edición 7, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311748

Instruct-ULTRA D8.3 Develop enhanced deposition of structural data to database

Autores: Conesa, Pablo
Publicado en: Edición 11, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311810

Instruct-ULTRA D7.1 Standardised workflows for production, crystallisation and data collection of membrane proteins

Autores: Archer, Magarida; Athayde, Diogo; van den Heuvel, Joop; Mohan Kaipa, Jagan; Krasnoselska, Ganna; Owens, Ray; Rodrigues, Jose; Rosario, Ana L.
Publicado en: Edición 4, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311797

Instruct-ULTRA D4.1 Call 1 launched for developing new service provision of existing technologies and selection of qualifying projects

Autores: Owens, Ray
Publicado en: Edición 10, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311720

Instruct-ULTRA D6.3 Publication of a position paper on the operation of NMR services and RIs in general as a guide for users in collaboration with WP3

Autores: Banci, Lucia; Boelens, Rolf; Morelli, Francesca; Pierattelli, Roberta; Wienk, Hans
Publicado en: Edición 1, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311787

Instruct-ULTRA D6.5 Implemented software package for remote access EM data

Autores: Bonnet, Frederic; Renault, Ludo
Publicado en: Edición 6, 2020
Editor: Zenodo
DOI: 10.5281/zenodo.4311793

In Vitro Production of Perdeuterated Proteins in H2O for Biomolecular NMR Studies

Autores: Lionel Imbert, Rachel Lenoir-Capello, Elodie Crublet, Alicia Vallet, Rida Awad, Isabel Ayala, Celine Juillan-Binard, Hubert Mayerhofer, Rime Kerfah, Pierre Gans, Emeric Miclet, Jerome Boisbouvier
Publicado en: Structural Genomics - General Applications, Edición 2199, 2021, Página(s) 127-149, ISBN 978-1-0716-0891-3
Editor: Springer US
DOI: 10.1007/978-1-0716-0892-0_8

TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair

Autores: Olga Kolesnikova, Laura Radu, Arnaud Poterszman
Publicado en: DNA Repair, Edición 115, 2019, Página(s) 21-67, ISBN 9780-128155592
Editor: Elsevier
DOI: 10.1016/bs.apcsb.2019.01.003

Derechos de propiedad intelectual

NOVEL ANTIGEN-BINDING CHIMERIC PROTEINS AND METHODS AND USES THEREOF

Número de solicitud/publicación: 20 18079891
Fecha: 2018-10-31

Buscando datos de OpenAIRE...

Resultado final

Publicaciones

Derechos de propiedad intelectual

Compartir esta página

Descargar