Periodic Reporting for period 3 - EU_FT-ICR_MS (European Network of Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry Centers)
Período documentado: 2021-01-01 hasta 2022-06-30
The Short Course 1 (SC1) is the first short course and the first event ever organized within the EU_FT-ICR_MS network at the University of Rostock, Rostock (Germany) during 5-7 March 2018 and has been quickly oversubscribed. The SC2 was held at Universitè Paris Sud, in Orsay (France) on 5-7 November 2018. The SC3 was held at Sapienza University, Roma (Italy) on 25-27 June 2019. The SC4 was held at the University of Warwick, Warwick (UK) on 22-23 August 2019. The SC5 5 was held at the Skolkovo Institute of Science and Technology (Skoltech), Moscow (Russia) on 10-12 October 2019. The SC6, originally planned in March 2020, has been organized at the Faculdade de Ciências of the Universidade de Lisboa, (Portugal) during September 2021. The SC7 was held at the BioCeV, Institute of Microbiology, Prague/Vestec (Czech Republic) on 16-19 August 2020. The number of participants to the SC ranged from 10 to 20. For all Short Course and School the student feedback received via a “satisfaction survey” was extremely positive.
The proposal to organize the 14th edition of the European FTMS conference in Lisbon, Portugal was presented by C. Cordeiro at the 13th European FTMS Workshop (Freising (Munich), Germany, April 2018) and accepted and was scheduled in April 2020. Due to Covid-19 pandemics, and in concertation with the American FT-ICR congress the European FTMS, has been delayed to Spring 2022. Finally, the European FTMS conference in Lisbon was postponed until July 2022.
Due to Covid-19 pandemics, in most sites, teams were not allowed to come in their laboratory from March to May 2020 and suffered from restricted access since this date. For most sites, the travel of Bruker maintenance engineers of Bruker who are located in Bremen Germany was also severely hampered by quarantine delay imposed when they came back to Germany.
Due to these restrictions to the FT-ICR instrument access and to the delay in maintenance, the number of days of TNA has been on average decreased on 2020. Nevertheless, as the consortium was in advance on its planning at the end of the year the TNA objectives for the three years were reached. During the second 1.5-year period (01 July 2019 to 31 December 2020) 40 projects were successfully completed within the entire EU FT-ICR MS network, 6 of which were follow-up of the first submission. The TNA accesses also restated at a very intense pace after borders re-opened. TNA accesses were submitted from 19 different countries. During the third reporting period (01 January 2021 – 30 June 2022), 57 projects were successfully completed within the entire EU FT-ICR MS network, 16 of which were follow-up of the first submissions.
The WP4 concerns Joint Research activities. Ultra-complex samples (tire oil pyrolysis products, fresh/aged bitumen) were jointly analyzed by direct infusion as well as coupling techniques, i.e. thermal analysis. This cooperation between UHRO, URO and UEF described methods for the ultra-complex organic mixtures with a strong focus to petrochemicals (bio-oils, plastic recycling, etc.). The Liege team described an optimized protocol for MALDI imaging. The French teams (Rouen, Lille) developed a new method for the analysis of polybutadienes and polyisoprenes based on mild chemical depolymerization. Lille team described a high throughput method to identify the species of paleontological bones.
Very exciting new developments have been developed by several sites of the consortium and has been published in open access journals. Among these developments we may emphasize (i) an harmonized cell with an open geometry by the Moscow site which allows longer transient and a better resolution; (ii) a software developed at the site of Liège which extend to MALDI imaging the Kendric and van Krevelen diagrams allowing a better data mining of this complex data; (iii) the implementation of UVPD (Ultraviolet Photodissociation) at the site of Warwick; and finally (iv) the site of Lille developed a genetic algorithm program which allows super-resolution close to the theoretical predicted limits. The 2 XR acquisition at high magnetic field has been postponed to the last 6 months of the project due to late delivery of the device by the manufacturer.