Transcranial brain stimulation as innovative therapy for chronic pediatric neuropsychiatric disorder – STIPED

Project Information

STIPED

Grant agreement ID: 731827

DOI 10.3030/731827

Project closed

EC signature date 9 December 2016

Start date 1 January 2017

End date 30 June 2022

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 6 195 231,25

EU contribution € 6 195 231,25

Coordinated by

EVANGELISCHES KLINIKUM BETHEL GGMBH
Germany

Deliverables

Websites, patent fillings, videos etc. (5)

Report on Stakeholder Involvement after Kick-Off Meeting

After Kick-Off meeting a report on stakeholder involvement will be published.

Final report on dissemination activities on project results

Final report on dissemination activities on project results will be presented to EC Parts of the final report will be published in press and social media

Scientific symposium/major dissemination/communication activity organised by Neuroelectrics

Scientific symposium about application of tDCS in pediatrics will be held in Barcelona organised by Neuroelectrics

Press release for every partner

Press release will be prepared by every partner.

Launch of website and social media accounts

A Website with all relevant Information of the project will be launched. Social media accounts will be established.

Documents, reports (2)

Submission of literature review on ethical aspects of TDCS in pediatrics

Literature review on ethical aspects of tDCS in pediatrics will be written and submitted in a scientific international peer review journal.

Recommendations for application of tDCS in paediatrics

Recommendations for application of tDCS in paediatrics will be submitted for publication in a peer review journal

Publications

Peer reviewed articles (20)

Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review

Author(s): Carla Cavaleiro, João Martins, Joana Gonçalves, Miguel Castelo-Branco
Published in: Neural Plasticity, Issue 2020, 2020, Page(s) 1-23, ISSN 2090-5904
Publisher: Neural Plasticity
DOI: 10.1155/2020/4795267

First Epileptic Seizure and Initial Diagnosis of Juvenile Myoclonus Epilepsy (JME) in a Transcranial Direct Current Stimulation (tDCS) Study– Ethical Analysis of a Clinical case

Author(s): Anna Sierawska, Vera Moliadze, Maike Splittgerber, Annette Rogge, Michael Siniatchkin, Alena Buyx
Published in: Neuroethics, Issue 13/3, 2020, Page(s) 347-351, ISSN 1874-5490
Publisher: Springer Science Business Media
DOI: 10.1007/s12152-020-09444-6

Economical Assessment of Working Memory and Response Inhibition in ADHD Using a Combined n-back/Nogo Paradigm: An ERP Study

Author(s): Carolin Breitling-Ziegler, Jana Tegelbeckers, Hans-Henning Flechtner, Kerstin Krauel
Published in: Frontiers in Human Neuroscience, Issue 14, 2020, ISSN 1662-5161
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnhum.2020.00322

Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study.

Author(s): Magdalena Schütz; Sara Boxhoorn; Andreas M. Mühlherr; Hannah Mössinger; Christine M. Freitag; Christina Luckhardt
Published in: Journal of Autism and Developmental Disorders, Issue 6, 2021, ISSN 1866-1955
Publisher: Spring Nature
DOI: 10.1007/s10803-021-05358-1

Individual Baseline Performance and Electrode Montage Impact on the Effects of Anodal tDCS Over the Left Dorsolateral Prefrontal Cortex

Author(s): Maike Splittgerber, Ricardo Salvador, Hannah Brauer, Carolin Breitling-Ziegler, Alexander Prehn-Kristensen, Kerstin Krauel, Rafal Nowak, Giulio Ruffini, Vera Moliadze, Michael Siniatchkin
Published in: Frontiers in Human Neuroscience, Issue 14, 2020, ISSN 1662-5161
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnhum.2020.00349

Phase-IIa randomized, double-blind, sham-controlled, parallel group trial on anodal transcranial direct current stimulation (tDCS) over the left and right tempo-parietal junction in autism spectrum disorder—StimAT: study protocol for a clinical trial

Author(s): Christina Luckhardt, Magdalena Schütz, Andreas Mühlherr, Hannah Mössinger, Sara Boxhoorn, Astrid Dempfle, Ricardo Salvador, Giulio Ruffini, Helena C. Pereira, Miguel Castelo-Branco, Marianne Latinus, Frédérique Bonnet-Brilhault, Julia Siemann, Michael Siniatchkin, Christine Ecker, Christine M. Freitag
Published in: Trials, Issue 22/1, 2021, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-021-05172-1

Exploration of a novel virtual environment improves memory consolidation in ADHD

Author(s): Valentin Baumann, Thomas Birnbaum, Carolin Breitling-Ziegler, Jana Tegelbeckers, Johannes Dambacher, Elke Edelmann, Jorge R. Bergado-Acosta, Hans-Henning Flechtner, Kerstin Krauel
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-78222-4

Virtual Travel Training for Autism Spectrum Disorder: Proof-of-Concept Interventional Study

Author(s): Marco Simões, Miguel Bernardes, Fernando Barros, Miguel Castelo-Branco
Published in: JMIR Serious Games, Issue 6/1, 2018, Page(s) e5, ISSN 2291-9279
Publisher: JMIR Publications
DOI: 10.2196/games.8428

Detection of generalized synchronization using echo state networks

Author(s): D. Ibáñez-Soria, J. Garcia-Ojalvo, A. Soria-Frisch, G. Ruffini
Published in: Chaos: An Interdisciplinary Journal of Nonlinear Science, Issue 28/3, 2018, Page(s) 033118, ISSN 1054-1500
Publisher: American Institute of Physics
DOI: 10.1063/1.5010285

Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavioural, EEG and fMRI study

Author(s): Gilberto Silva, Isabel Catarina Duarte, Inês Bernardino, Tânia Marques, Inês R. Violante, Miguel Castelo-Branco
Published in: Journal of Neurodevelopmental Disorders, Issue 10/1, 2018, ISSN 1866-1947
Publisher: Springer Verlag
DOI: 10.1186/s11689-018-9230-4

No Modulatory Effects when Stimulating the Right Inferior Frontal Gyrus with Continuous 6 Hz tACS and tRNS on Response Inhibition: A Behavioral Study

Author(s): Hannah Brauer, Navah Ester Kadish, Anya Pedersen, Michael Siniatchkin, Vera Moliadze
Published in: Neural Plasticity, Issue 2018, 2018, Page(s) 1-11, ISSN 2090-5904
Publisher: Hindawi
DOI: 10.1155/2018/3156796

Stimulus dependent neural oscillatory patterns show reliable statistical identification of autism spectrum disorder in a face perceptual decision task

Author(s): João Castelhano, Paula Tavares, Susana Mouga, Guiomar Oliveira, Miguel Castelo-Branco
Published in: Clinical Neurophysiology, Issue 129/5, 2018, Page(s) 981-989, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2018.01.072

Unmet Needs in Children With Attention Deficit Hyperactivity Disorder—Can Transcranial Direct Current Stimulation Fill the Gap? Promises and Ethical Challenges

Author(s): Anna Sierawska, Alexander Prehn-Kristensen, Vera Moliadze, Kerstin Krauel, Rafal Nowak, Christine M. Freitag, Michael Siniatchkin, Alena Buyx
Published in: Frontiers in Psychiatry, Issue 10, 2019, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2019.00334

First generalized tonic clonic seizure in the context of pediatric tDCS – A case report

Author(s): Maike Splittgerber, Natia Japaridze, Anna Sierawska, Sandra Gimenez, Rafal Nowak, Michael Siniatchkin, Vera Moliadze
Published in: Neurophysiologie Clinique, 2019, ISSN 0987-7053
Publisher: Elsevier Masson
DOI: 10.1016/j.neucli.2019.11.002

Characterization of the non-stationary nature of steady-state visual evoked potentials using echo state networks

Author(s): David Ibáñez-Soria, Aureli Soria-Frisch, Jordi Garcia-Ojalvo, Giulio Ruffini
Published in: PLOS ONE, Issue 14/7, 2019, Page(s) e0218771, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0218771

Value and limitations of intracranial recordings for validating electric field modeling for transcranial brain stimulation

Author(s): Oula Puonti, Guilherme B. Saturnino, Kristoffer H. Madsen, Axel Thielscher
Published in: NeuroImage, Issue 208, 2020, Page(s) 116431, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.116431

Comparison between conventional and HD-tDCS of the right inferior frontal gyrus in children and adolescents with ADHD

Author(s): Carolin Breitling, Tino Zaehle, Moritz Dannhauer, Jana Tegelbeckers, Hans-Henning Flechtner, Kerstin Krauel
Published in: Clinical Neurophysiology, 2020, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2019.12.412

Multichannel anodal tDCS over the left dorsolateral prefrontal cortex in a paediatric population

Author(s): Splittgerber, Maike; Borzikowsky, Christoph; Salvador, Ricardo; Puonti, Oula; Papadimitriou, Kiriaki; Merschformann, Christoph; Biagi, Maria Chiara; Stenner, Tristan; Brauer, Hannah; Breitling-Ziegler, Carolin; Prehn-Kristensen, Alexander; Krauel, Kerstin; Ruffini, Giulio; Pedersen, Anya; Nees, Frauke; Thielscher, Axel; Dempfle, Astrid; Siniatchkin, Michael; Moliadze, Vera
Published in: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021), Issue 2, 2021, Page(s) 1-15, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-00933-z

Non-invasive brain stimulation and neuroenhancement

Author(s): Andrea Antal, Bruce Luber, Anna-Katharine Brem, Marom Bikson, Andre R. Brunon, Roi Cohen, Kadosh Veljko Dubljević, Shirley Fecteau, Florinda Ferreri, Agnes Flöel, Mark Hallett, Roy H.Hamilton, Christoph S.Herrmann, Michal Lavidor, Collen Loo, Caroline Lustenberger, Sergio Machado, Carlo Miniussi, Vera Moliadze, Michael A.Nitsche, Simone Rossi, Paolo M.Rossini, Emiliano Santarnecchi, Margitta See
Published in: Clinical Neurophysiology Practice, Issue Volume 7, 2022, 2022, Page(s) Pages 146-165, ISSN 2467-981X
Publisher: Elsevier B.V.
DOI: 10.1016/j.cnp.2022.05.002

Accurate and robust whole-head segmentation from magnetic resonance images for individualized head modeling

Author(s): Oula Puonti, KoenVan Leemput, Guilherme B.Saturnino, Hartwig R.Siebner, Kristoffer H.Madsen, AxelThielscher
Published in: Science Direct - Neuroimage, Issue Volumen 219, 2020, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.117044

Book chapters (8)

Effects of anodal multichannel transcranial direct current stimulation (tDCS) on social-cognitive performance in healthy subjects: A randomized sham-controlled crossover pilot study

Author(s): H. Catarina Pereira, Daniela Sousa, Marco Simões, Ricardo Martins, Carlos Amaral, Vânia Lopes, Joana Crisóstomo, Miguel Castelo-Branco
Published in: Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Issue 264, 2021, Page(s) 259-286, ISBN 9780128223444
Publisher: Elsevier
DOI: 10.1016/bs.pbr.2021.04.004

SimNIBS 2.1: A Comprehensive Pipeline for Individualized Electric Field Modelling for Transcranial Brain Stimulation

Author(s): Guilherme B. Saturnino, Oula Puonti, Jesper D. Nielsen, Daria Antonenko, Kristoffer H. Madsen, Axel Thielscher
Published in: Brain and Human Body Modeling - Computational Human Modeling at EMBC 2018, 2019, Page(s) 3-25, ISBN 978-3-030-21292-6
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-21293-3_1

Personalization of Multi-electrode Setups in tCS/tES: Methods and Advantages

Author(s): R. Salvador, M. C. Biagi, O. Puonti, M. Splittgerber, V. Moliadze, M. Siniatchkin, A. Thielscher, G. Ruffini
Published in: Brain and Human Body Modeling 2020 - Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting, 2021, Page(s) 119-135, ISBN 978-3-030-45622-1
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-45623-8_7

Transcranial direct-current stimulation and pediatric attention deficit hyperactivity disorder (ADHD)—Findings from an interview ethics study with children, adolescents, and their parents

Author(s): Anna Sierawska, Alexander Prehn-Kristensen, Hannah Brauer, Kerstin Krauel, Carolin Breitling-Ziegler, Michael Siniatchkin, Alena Buyx
Published in: Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Issue 264, 2021, Page(s) 363-386, ISBN 9780128223444
Publisher: Elsevier
DOI: 10.1016/bs.pbr.2021.04.002

Effects of a five-day HD-tDCS application to the right IFG depend on current intensity: A study in children and adolescents with ADHD

Author(s): Carolin Breitling-Ziegler; Tino Zaehle; Christian Wellnhofer; Moritz Dannhauer; Jana Tegelbeckers; Valentin Baumann; Hans-Henning Flechtner; Kerstin Krauel
Published in: Progress in Brain Research, Issue 3, 2021, Page(s) 117-150, ISBN 978-0-12-822344-4
Publisher: Elsevier
DOI: 10.1016/bs.pbr.2021.01.014

Transcranial direct current stimulation in attention-deficit/hyperactivity disorder: A meta-analysis of clinical efficacy outcomes

Author(s): Hannah Brauer, Carolin Breitling-Ziegler, Vera Moliadze, Britta Galling, Alexander Prehn-Kristensen
Published in: Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Issue 264, 2021, Page(s) 91-116, ISBN 9780128223444
Publisher: Elsevier
DOI: 10.1016/bs.pbr.2021.01.013

Brain stimulation by tDCS as treatment option in Autism Spectrum Disorder—A systematic literature review

Author(s): Christina Luckhardt, Sara Boxhoorn, Magdalena Schütz, Nikola Fann, Christine M. Freitag
Published in: Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Issue 264, 2021, Page(s) 233-257, ISBN 9780128223444
Publisher: Elsevier
DOI: 10.1016/bs.pbr.2021.03.002

Chapter 2 - Cortical current density magnitudes during transcranial direct current stimulation correlate with skull thickness in children, adolescent and young adults

Author(s): Alexander Hunold, Jens Haueisen, Christine M.Freitag, Michael Siniatchkin, Vera Moliadze
Published in: Progress in Brain Research, Issue Vol 264,2021, 2021, Page(s) 41-56, ISBN 978-0-12-822344-4
Publisher: Elsevier
DOI: 10.1016/bs.pbr.2021.01.010

Non-peer reviewed articles (5)

tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel

Author(s): Tulika Nandi, Oula Puonti, William T. Clarke, Caroline Nettekoven, Helen C. Barron, James Kolasinski, Taylor Hanayik, Emily L. Hinson, Adam Berrington, Velicia Bachtiar, Ainslie Johnstone, Anderson M. Winkler, Axel Thielscher, Heidi Johansen-Berg, Charlotte J. Stagg
Published in: Biorxiv The preprint server for Biology, Issue April 28/2022, 2022, ISSN 2692-8205
Publisher: Biorxiv
DOI: 10.1101/2022.04.27.489665

P 16. Multichannel anodal transcranial direct current stimulation over the right inferior frontal gyrus in pediatric population: preliminary behavioural results

Author(s): C. Merschformann, M. Splittgerber, C. Borzikowsky, K. Papadimitriou, R. Salvador, C. Breitling-Ziegler, H. Brauer, K. Krauel, A. Prehn-Kristensen, F. Nees, A. Dempfle, M. Siniatchkin, V. Moliadze
Published in: Clinical Neurophysiology, Issue 132/8, 2021, Page(s) e7-e8, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2021.02.338

The boundaries of state-space Granger causality analysis applied to BOLD simulated data: A comparative modelling and simulation approach

Author(s): Tiago Timóteo Fernandes, Bruno Direito, Alexandre Sayal, João Pereira, Alexandre Andrade, Miguel Castelo-Branco
Published in: Journal of Neuroscience Methods, Issue 341, 2020, Page(s) 108758, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2020.108758

Resting Eyes Closed Beta-Phase High Gamma-Amplitude Coupling Deficits in Children with Attention Deficit Hyperactivity Disorder

Author(s): David Ibanez-Soria1*, Eleni Kroupi1, Andrés Rojas1, Marta Castellano1, Jacobo Picardo2, Gloria García- Banda2, Belen Saez2, Mateu Servera2, Giulio Ruffini1,3, Aureli Soria-Frisch1.
Published in: bioRxiv the reprint server for biology, 2019, ISSN 2049-3630
Publisher: bioRxiv the reprint server for biology
DOI: 10.1101/598003

P 17. Multichannel tDCS on the left DLPFC in healthy children and adolescents: A behavioral study

Author(s): K. Papadimitriou, M. Splittgerber, C. Borzikowsky, C. Merschformann, R. Salvador, H. Brauer, C. Breitling-Ziegler, A. Prehn-Kristensen, K. Krauel, F. Nees, A. Dempfle, M. Siniatchkin, V. Moliadze
Published in: Clinical Neurophysiology, Issue 132/8, 2021, Page(s) e8, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2021.02.339

Other (3)

Comparing and Validating Automated Tools for Individualized Electric Field Simulations in the Human Head

Author(s): Oula Puonti, Guilherme B. Saturnino, Kristoffer H. Madsen, Axel Thielscher
Published in: The preprint server for Biology, 2019
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/611962

Economical Assessment of Working Memory and Response Inhibition in ADHD Using a Combined n-back/Nogo Paradigm: An ERP Study

Author(s): Breitling-Ziegler, Carolin; Tegelbeckers, Jana; Flechtner, Hans-Henning; Krauel, Kerstin
Published in: Frontiers in Human Neuroscience, Issue 1, 2020
Publisher: Frontiers Media S.A.

Hypoarousal non-stationary ADHD biomarker based on echo-state networks

Author(s): Picardo, Jacobo; Garcia-Ojalvo, Jordi; Garcia-Banda, Gloria; Servera, Mateu; Ruffini, Giulio; Soria-Frisch, Aureli; Soria, David
Published in: Issue 2, 2018
Publisher: bioRxiv
DOI: 10.1101/271858

Conference proceedings (1)

Accurate anatomical head segmentations: a data set for biomedical simulations

Author(s): Silvia Farcito, Oula Puonti, Hazael Montanaro, Guilherme B. Saturnino, Jesper D. Nielsen, Camilla G. Madsen, Hartwig R. Siebner, Esra Neufeld, Niels Kuster, Bryn A. Lloyd, Axel Thielscher
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 6118-6123, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857041