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SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS

Deliverables

Publications

Left Ventricular Longitudinal Contractility Predicts Acute‐on‐Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt

Author(s): Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka
Published in: Hepatology Communications, Issue 3/3, 2019, Page(s) 340-347, ISSN 2471-254X
DOI: 10.1002/hep4.1308

Pro: Acute-on-chronic liver failure

Author(s): Elsa Solà, Pere Ginès
Published in: Liver Transplantation, Issue 23/10, 2017, Page(s) 1318-1324, ISSN 1527-6465
DOI: 10.1002/lt.24812

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Author(s): Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Published in: Clinical and Translational Gastroenterology, Issue 10/4, 2019, Page(s) e00025, ISSN 2155-384X
DOI: 10.14309/ctg.0000000000000025

Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

Author(s): Gabriel Mezzano, Adria Juanola, Andres Cardenas, Esteban Mezey, James P Hamilton, Elisa Pose, Isabel Graupera, Pere Ginès, Elsa Solà, Ruben Hernaez
Published in: Gut, Issue gutjnl-2020-322161, 2020, Page(s) gutjnl-2020-322161, ISSN 0017-5749
DOI: 10.1136/gutjnl-2020-322161

The microbiota in cirrhosis and its role in hepatic decompensation

Author(s): Jonel Trebicka, Jane Macnaughtan, Bernd Schnabl, Debbie L. Shawcross, Jasmohan S. Bajaj
Published in: Journal of Hepatology, Issue 75, 2021, Page(s) S67-S81, ISSN 0168-8278
DOI: 10.1016/j.jhep.2020.11.013

The Use of Rifaximin in Patients With Cirrhosis

Author(s): Paolo Caraceni, Victor Vargas, Elsa Solà, Carlo Alessandria, Koos Wit, Jonel Trebicka, Paolo Angeli, Rajeshwar P. Mookerjee, François Durand, Elisa Pose, Aleksander Krag, Jasmohan S. Bajaj, Ulrich Beuers, Pere Ginès, Adrià Juanola, Laura Napoleone, Marta Carol, Emma Avitabile, Ann Ma Thu, Marta Cervera, Martina Pérez, Ana Belén Rubio‐Garcia, Alicia Ardiaca, Adriana Vives, Judit Pich, Núri
Published in: Hepatology, 2021, ISSN 0270-9139
DOI: 10.1002/hep.31708

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Author(s): Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Published in: PLOS ONE, Issue 14/10, 2019, Page(s) e0222840, ISSN 1932-6203
DOI: 10.1371/journal.pone.0222840

Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Author(s): Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna
Published in: Liver Transplantation, Issue 26/2, 2019, Page(s) 283-293, ISSN 1527-6465
DOI: 10.1002/lt.25678

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Author(s): Delia Blaya, Elisa Pose, Mar Coll, Juan José Lozano, Isabel Graupera, Robert Schierwagen, Christian Jansen, Pedro Castro, Sara Fernandez, Julia Sidorova, Mariuca Vasa-Nicotera, Elsa Solà, Joan Caballería, Jonel Trebicka, Pere Ginès, Pau Sancho-Bru
Published in: JHEP Reports, Issue 3/2, 2021, Page(s) 100233, ISSN 2589-5559
DOI: 10.1016/j.jhepr.2021.100233

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Author(s): Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Published in: Frontiers in Immunology, Issue 11, 2020, Page(s) 354, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.00354

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Author(s): Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3308, ISSN 1422-0067
DOI: 10.3390/ijms21093308

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Author(s): Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka
Published in: JHEP Reports, Issue 3/3, 2021, Page(s) 100264, ISSN 2589-5559
DOI: 10.1016/j.jhepr.2021.100264

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Author(s): Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Published in: Gut, 2021, Page(s) gutjnl-2019-320170, ISSN 0017-5749
DOI: 10.1136/gutjnl-2019-320170

Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

Author(s): Maria Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo, Alexander Queck, Wenyi Gu, Robert Schierwagen, Jennifer Lehmann, Frank E. Uschner, Christiana Graf, Christian P. Strassburg, Javier Fernandez, Tatjana Stojakovic, Rainer Woitas, Jonel Trebicka
Published in: Liver International, Issue 40/1, 2019, Page(s) 186-193, ISSN 1478-3223
DOI: 10.1111/liv.14230

Acute Decompensation and Acute-on-Chronic Liver Failure

Author(s): Philip Ferstl, Jonel Trebicka
Published in: Clinics in Liver Disease, Issue 25/2, 2021, Page(s) 419-430, ISSN 1089-3261
DOI: 10.1016/j.cld.2021.01.009

Endpoints and design of clinical trials in patients with decompensated cirrhosis: Position paper of the LiverHope Consortium

Author(s): Elsa Solà, Elisa Pose, Daniela Campion, Salvatore Piano, Olivier Roux, Macarena Simon-Talero, Frank Uschner, Koos de Wit, Giacomo Zaccherini, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, Rajeshwar P. Mookerjee, Jonel Trebicka, Victor Vargas, Miquel Serra, Ferran Torres, Sara Montagnese, Aleksander Krag, Ruben Hernaez, Marko Korenjak, Hugh Watson, Juan G. Abraldes, Patrick S.
Published in: Journal of Hepatology, Issue 74/1, 2021, Page(s) 200-219, ISSN 0168-8278
DOI: 10.1016/j.jhep.2020.08.009

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

Author(s): Katharina Maria Schwarzkopf, Larissa Eberle, Frank Erhard Uschner, Sabine Klein, Robert Schierwagen, Marcus Maximilian Mücke, Liliana Schaefer, Joan Clària, Stefan Zeuzem, Edith Hintermann, Urs Christen, Christian Markus Lange, Jonel Trebicka, Christoph Welsch
Published in: Journal of Hepatology, Issue 73/4, 2020, Page(s) 980-982, ISSN 0168-8278
DOI: 10.1016/j.jhep.2020.05.012

Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis

Author(s): Cristina Solé, Susie Guilly, Kevin Da Silva, Marta Llopis, Emmanuelle Le-Chatelier, Patricia Huelin, Marta Carol, Rebeca Moreira, Núria Fabrellas, Gloria De Prada, Laura Napoleone, Isabel Graupera, Elisa Pose, Adrià Juanola, Natalia Borruel, Magali Berland, David Toapanta, Francesc Casellas, Francisco Guarner, Jöel Doré, Elsa Solà, Stanislav Dusko Ehrlich, Pere Ginès
Published in: Gastroenterology, Issue 160/1, 2021, Page(s) 206-218.e13, ISSN 0016-5085
DOI: 10.1053/j.gastro.2020.08.054

Acute-on-chronic liver failure: an update

Author(s): Ruben Hernaez, Elsa Solà, Richard Moreau, Pere Ginès
Published in: Gut, Issue 66/3, 2017, Page(s) 541-553, ISSN 0017-5749
DOI: 10.1136/gutjnl-2016-312670

Hepatorenal syndrome in the era of acute kidney injury

Author(s): Cristina Solé, Elisa Pose, Elsa Solà, Pere Ginès
Published in: Liver International, 2018, ISSN 1478-3223
DOI: 10.1111/liv.13893

Statins: old drugs as new therapy for liver diseases?

Author(s): Elisa Pose, Jonel Trebicka, Rajeshwar P. Mookerjee, Paolo Angeli, Pere Ginès
Published in: Journal of Hepatology, 2018, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.07.019

More Than Meets the Eye in Using Interleukin 6 as a Marker of Inflammation and Prognostic Factor for Patients With Cirrhosis

Author(s): Pere Ginès, Shiv Sarin
Published in: Clinical Gastroenterology and Hepatology, Issue 16/5, 2018, Page(s) 630-632, ISSN 1542-3565
DOI: 10.1016/j.cgh.2017.12.031

Nursing care of patients with cirrhosis

Author(s): Núria Fabrellas, Marta Carol, Ester Palacio, Marites Aban, Tommaso Lanzillotti, Gea Nicolao, Maria Teresa Chiappe, Vanessa Esnault, Sabine Graf‐Dirmeier, Jeltje Helder, Andrea Gossard, Mireia Lopez, Marta Cervera, Lacey L. Dols, Elsa Solà, Elisa Pose, Paolo Caraceni, Victor Vargas, Carlo Alessandria, Ulrich Beuers, Jonel Trebicka, François Durand, Rajeshwar Mookerjee, Paolo Angeli, Marko Kore
Published in: Hepatology, 2020, ISSN 0270-9139
DOI: 10.1002/hep.31117

Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial

Author(s): Elisa Pose, Laura Napoleone, Ahmed Amin, Daniela Campion, César Jimenez, Salvatore Piano, Olivier Roux, Frank Erhard Uschner, Koos de Wit, Giacomo Zaccherini, Carlo Alessandria, Paolo Angeli, Mauro Bernardi, Ulrich Beuers, Paolo Caraceni, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Raúl J Andrade, Marta Carol, Judit Pich, Juan Ferrero, Gema Domenech, Marta Llopis, Fer
Published in: The Lancet Gastroenterology & Hepatology, Issue 5/1, 2020, Page(s) 31-41, ISSN 2468-1253
DOI: 10.1016/s2468-1253(19)30320-6

Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival

Author(s): Cristina Solé, Elsa Solà, Patricia Huelin, Marta Carol, Rebeca Moreira, Unai Cereijo, José‐Manuel Mas, Isabel Graupera, Elisa Pose, Laura Napoleone, Gloria dePrada, Adrià Juanola, Núria Fabrellas, Ferran Torres, Manuel Morales‐Ruiz, Judith Farrés, Wladimiro Jiménez, Pere Ginès
Published in: Liver International, Issue 39/7, 2019, Page(s) 1246-1255, ISSN 1478-3223
DOI: 10.1111/liv.14037

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Author(s): Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Published in: PLOS ONE, Issue 15/4, 2020, Page(s) e0231701, ISSN 1932-6203
DOI: 10.1371/journal.pone.0231701

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Author(s): Jonel Trebicka, Wenyi Gu, Victor de Ledinghen, Christophe Aubé, Aleksander Krag, Michael Praktiknjo, Laurent Castera, Jerome Dumortier, David Josef Maria Bauer, Mireen Friedrich-Rust, Stanislas Pol, Ivica Grgurevic, Rongqin Zheng, Sven Francque, Halima Gottfriedovà, Sanda Mustapic, Ioan Sporea, Annalisa Berzigotti, Frank Erhard Uschner, Benedikt Simbrunner, Maxime Ronot, Christophe Cassinotto, M
Published in: Gut, 2021, Page(s) gutjnl-2020-323419, ISSN 0017-5749
DOI: 10.1136/gutjnl-2020-323419

Are We Ready to Evaluate Adrenal Function in Patients With Decompensated Cirrhosis and Acute-on-Chronic Liver Failure?

Author(s): Cristina Solé, Elsa Solà, Pere Ginès
Published in: Clinical Gastroenterology and Hepatology, Issue 18/5, 2020, Page(s) 1040-1042, ISSN 1542-3565
DOI: 10.1016/j.cgh.2019.11.031

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Author(s): Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Published in: Gut, Issue 69/8, 2020, Page(s) 1535-1536, ISSN 0017-5749
DOI: 10.1136/gutjnl-2019-319044

Cardiodynamic state is associated with systemic inflammation and fatal acute‐on‐chronic liver failure

Author(s): Michael Praktiknjo, Sofia Monteiro, Josephine Grandt, Nina Kimer, Jan L. Madsen, Mikkel P. Werge, Peter William, Maximilian J. Brol, Laura Turco, Robert Schierwagen, Johannes Chang, Sabine Klein, Frank E. Uschner, Christoph Welsch, Richard Moreau, Filippo Schepis, Flemming Bendtsen, Lise L. Gluud, Søren Møller, Jonel Trebicka
Published in: Liver International, Issue 40/6, 2020, Page(s) 1457-1466, ISSN 1478-3223
DOI: 10.1111/liv.14433

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Author(s): Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Published in: Liver Transplantation, Issue 26/7, 2020, Page(s) 906-915, ISSN 1527-6465
DOI: 10.1002/lt.25788

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Author(s): Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Published in: Journal of Clinical Medicine, Issue 8/4, 2019, Page(s) 419, ISSN 2077-0383
DOI: 10.3390/jcm8040419