SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS

Deliverables

Communication material for patient associations, patients and families enrolled_I

communication material for patients and their families

Presentation of LIVERHOPE at ELPA Symposium and possible other venue

public presentations of LIVEHOPE in international meetings

Communication material for patient associations, patients and families enrolled_III

communication material

Communication material for patient associations, patients and families enrolled_II

communication material

Communication material for patient associations, patients and families enrolled_IV

communication material

Space for LIVERHOPE on the ELPA web sit

web site

Publications and material for communication (flyers, press release, videos, seminars, publications)_I

communication material and publications

Project web site

web site

Publications and material for communication (flyers, press release, videos, seminars, publications)_II

communication material and publications

Publications and material for communication (flyers, press release, videos, seminars, publications)_III

communication material and publications

Initial dissemination plan

document that will report the actions discussed and decided during the kick off meeting

Final analysis report on cost-effectiveness and cost-utility, included budget impact analysis and sensivity analysis, both univariate and probabilistic

report

Project visual identity

logo and indication for producing project documents

Final dissemination plan

report of the actions decided and discussed during the final meeting

Interim analysis report on cost-effectiveness and cost-utility, included budget impact analysis and sensivity analysis, both univariate and probabilistic

report

Publications

Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1

Author(s): Cristina Ortiz, Sabine Klein, Winfried H Reul, Fernando Magdaleno, Stefanie Gröschl, Peter Dietrich, Robert Schierwagen, Frank E Uschner, Sandra Torres, Christoph Hieber, Caroline Meier, Nico Kraus, Olaf Tyc, Maximilian Brol, Stefan Zeuzem, Christoph Welsch, Marco Poglitsch, Claus Hellerbrand, Mercedes Alfonso-Prieto, Fabio Mira, Ulrich Auf dem Keller, Anja Tetzner, Andrew Moore, Thomas Walther,
Published in: Cell Rep, Issue 42(2), 2023, Page(s) 112059
Publisher: -
DOI: 10.1016/j.celrep.2023.112059

Left Ventricular Longitudinal Contractility Predicts Acute‐on‐Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt

Author(s): Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka
Published in: Hepatology Communications, Issue 3/3, 2019, Page(s) 340-347, ISSN 2471-254X
Publisher: -
DOI: 10.1002/hep4.1308

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Author(s): Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Published in: Clinical and Translational Gastroenterology, Issue 10/4, 2019, Page(s) e00025, ISSN 2155-384X
Publisher: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000025

Prevention of Cirrhosis Complications: Looking for Potential Disease Modifying Agents

Author(s): Giacomo Zaccherini, Manuel Tufoni, Mauro Bernardi and Paolo Caraceni
Published in: J. Clin. Med., Issue 10(19), 2021, Page(s) 4590
Publisher: -
DOI: 10.3390/jcm10194590

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.

Author(s): Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, Engelmann C, Zhang P, Jeong JY, van Vugt JLA, Xiao H, Deng H, Gao X, Ye Q, Zhang J, Yang L, Cai Y, Liu Y, Liu N, Li Z, Han T, Kaido T, Sohn JH, Strassburg C, Berg T, Trebicka J, Hsu YC, IJzermans JNM, Wang J, Su GL, Ji F, Nguyen MH.
Published in: J Hepatol., Issue Mar;76(3), 2022, Page(s) 588-599
Publisher: -
DOI: 10.1016/j.jhep.2021.11.006

The microbiota in cirrhosis and its role in hepatic decompensation

Author(s): Jonel Trebicka, Jane Macnaughtan, Bernd Schnabl, Debbie L. Shawcross, Jasmohan S. Bajaj
Published in: Journal of Hepatology, Issue 75, 2021, Page(s) S67-S81, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.11.013

The Use of Rifaximin in Patients With Cirrhosis

Author(s): Paolo Caraceni, Victor Vargas, Elsa Solà, Carlo Alessandria, Koos Wit, Jonel Trebicka, Paolo Angeli, Rajeshwar P. Mookerjee, François Durand, Elisa Pose, Aleksander Krag, Jasmohan S. Bajaj, Ulrich Beuers, Pere Ginès, Adrià Juanola, Laura Napoleone, Marta Carol, Emma Avitabile, Ann Ma Thu, Marta Cervera, Martina Pérez, Ana Belén Rubio‐Garcia, Alicia Ardiaca, Adriana Vives, Judit Pich, Núri
Published in: Hepatology, 2021, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31708

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Author(s): Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Published in: PLOS ONE, Issue 14/10, 2019, Page(s) e0222840, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0222840

Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Author(s): Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna
Published in: Liver Transplantation, Issue 26/2, 2019, Page(s) 283-293, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25678

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Author(s): Delia Blaya, Elisa Pose, Mar Coll, Juan José Lozano, Isabel Graupera, Robert Schierwagen, Christian Jansen, Pedro Castro, Sara Fernandez, Julia Sidorova, Mariuca Vasa-Nicotera, Elsa Solà, Joan Caballería, Jonel Trebicka, Pere Ginès, Pau Sancho-Bru
Published in: JHEP Reports, Issue 3/2, 2021, Page(s) 100233, ISSN 2589-5559
Publisher: -
DOI: 10.1016/j.jhepr.2021.100233

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Author(s): Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Published in: Frontiers in Immunology, Issue 11, 2020, Page(s) 354, ISSN 1664-3224
Publisher: -
DOI: 10.3389/fimmu.2020.00354

Nursing Care For Patients With Cirrhosis.

Author(s): Núria Fabrellas, Patrizia Künzler-Heule, Amy Olofson, Kathryn Jack, Marta Carol.
Published in: J Hepatol, 2023, Page(s) S0168-8278(23)00082-X
Publisher: -
DOI: 10.1016/j.jhep.2023.01.029

Changes in the epidemiology and management of bacterial infections in cirrhosis.

Author(s): Piano S, Tonon M, Angeli P.
Published in: Clin Mol Hepatol., Issue 27(3), 2021, Page(s) 437-445, ISSN 2287-285x
Publisher: The Korean Association for the Study of the Liver
DOI: 10.3350/cmh.2020.0329

Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis

Author(s): Adrià Juanola, Isabel Graupera, Chiara Elia, Salvatore Piano, Cristina Solé, Marta Carol, Martina Pérez-Guasch, Octavi Bassegoda, Laia Escudé, AnaBelén Rubio, Marta Cervera, Laura Napoleone, Emma Avitabile, AnnT. Ma, Núria Fabrellas, Elisa Pose, Manuel Morales Ruiz, Wladimiro Jiménez, Ferran Torres, Gonzalo Crespo, Pere Ginès
Published in: Journal of Hepatology, Issue Volume 76, Issue 1,, 2022, Page(s) J107-114, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.08.031

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Author(s): Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3308, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093308

Long-term albumin treatment in patients with cirrhosis and ascites

Author(s): Paolo Caraceni, Alastair O’Brien, Pere Gines
Published in: Journal of Hepatology, Issue Volume 76, Issue 6,, 2022, Page(s) 1306-1317, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2022.03.005

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Author(s): Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka
Published in: JHEP Reports, Issue 3/3, 2021, Page(s) 100264, ISSN 2589-5559
Publisher: -
DOI: 10.1016/j.jhepr.2021.100264

Programmed Death Ligand 1 Is Overexpressed in Liver Macrophages in Chronic Liver Diseases, and Its Blockade Improves the Antibacterial Activity Against Infections.

Author(s): Elisa Pose, Mar Coll, Celia Martínez‐Sánchez, Zhutian Zeng, Bas G. J. Surewaard, Cristina Català, María Velasco‐de Andrés, Juan José Lozano, Sílvia Ariño, David Fuster, Aida Niñerola‐Bazán, Isabel Graupera, Érica Muñoz, Francisco Lozano, Pau Sancho‐Bru, Paul Kubes, and Pere Ginès.
Published in: Hepatology, Issue 74(1), 2021, Page(s) 296–311, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31644

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Author(s): Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Published in: Gut, 2021, Page(s) gutjnl-2019-320170, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-320170

The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

Author(s): Tom H Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J Hutchinson, Bruno Sangro, Natasha K Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J Verkade, Ekkehard Sturm, Giulio Marchesi
Published in: Lancet, Issue 399(10319), 2022, Page(s) 61-116, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(21)01701-3

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Author(s): Sandra Torres, Maximilian J Brol, Fernando Magdaleno, Robert Schierwagen, Frank E. Uschner, Sabine Klein, Cristina Ortiz, Olaf Tyc, Nadine Bachtler, James Stunden, Damien Bertheloot, Ana Kitanovic, Brian Sanchez, Jacob Schrum, William R. Roush, Luigi Franchi, Kate Byth, Eicke Latz, and Jonel Trebicka
Published in: Front Mol Biosci., Issue 8, 2021, Page(s) 715765
Publisher: -
DOI: 10.3389/fmolb.2021.715765

Management of Ascites in Patients with Cirrhosis: An Update

Author(s): Giacomo Zaccherini, Manuel Tufoni, Giulia Iannone and Paolo Caraceni.
Published in: J. Clin. Med., Issue 10(22), 2021, Page(s) 5226
Publisher: -
DOI: 10.3390/jcm10225226

Acute Decompensation and Acute-on-Chronic Liver Failure

Author(s): Philip Ferstl, Jonel Trebicka
Published in: Clinics in Liver Disease, Issue 25/2, 2021, Page(s) 419-430, ISSN 1089-3261
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cld.2021.01.009

Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis

Author(s): Elisa Pose , Elsa Solà, Juan J Lozano, Adrià Juanola, Julia Sidorova, Giacomo Zaccherini, Koos de Wit , Frank Uschner, Marta Tonon, Konstantin Kazankov, Cesar Jiménez, Daniela Campion, Laura Napoleone, Ann T Ma, Marta Carol, Manuel Morales-Ruiz , Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Pi
Published in: Hepatol Commun, 2021
Publisher: Wiley
DOI: 10.1002/hep4.1881

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?

Author(s): Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka, and Robert Schierwagen
Published in: Front Med (Lausanne), Issue 9, 2022, Page(s) 1100966.
Publisher: -
DOI: 10.3389/fmed.2022.1100966

Endpoints and design of clinical trials in patients with decompensated cirrhosis: Position paper of the LiverHope Consortium

Author(s): Elsa Solà, Elisa Pose, Daniela Campion, Salvatore Piano, Olivier Roux, Macarena Simon-Talero, Frank Uschner, Koos de Wit, Giacomo Zaccherini, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, Rajeshwar P. Mookerjee, Jonel Trebicka, Victor Vargas, Miquel Serra, Ferran Torres, Sara Montagnese, Aleksander Krag, Ruben Hernaez, Marko Korenjak, Hugh Watson, Juan G. Abraldes, Patrick S.
Published in: Journal of Hepatology, Issue 74/1, 2021, Page(s) 200-219, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.08.009

Clinical Application of Kidney Biomarkers in Cirrhosis

Author(s): Allegretti AS, Solà E, Ginès P.
Published in: Am J Kidney Dis., Issue Nov;76(5), 2020, Page(s) 710-719
Publisher: National Kidney Foundation, Inc.
DOI: 10.1053/j.ajkd.2020.03.016

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

Author(s): Katharina Maria Schwarzkopf, Larissa Eberle, Frank Erhard Uschner, Sabine Klein, Robert Schierwagen, Marcus Maximilian Mücke, Liliana Schaefer, Joan Clària, Stefan Zeuzem, Edith Hintermann, Urs Christen, Christian Markus Lange, Jonel Trebicka, Christoph Welsch
Published in: Journal of Hepatology, Issue 73/4, 2020, Page(s) 980-982, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.05.012

Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients

Author(s): Anton Faron, Jasmin Abu-Omar, Johannes Chang, Nina Böhling, Alois Martin Sprinkart, Ulrike Attenberger, Jürgen K Rockstroh, Andreas Minh Luu, Christian Jansen, Christian P Strassburg, Jonel Trebicka, Julian Luetkens, Michael Praktiknjo
Published in: Front Med (Lausanne), Issue 9, 2022, Page(s) 831005
Publisher: -
DOI: 10.3389/fmed.2022.831005

Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis

Author(s): Cristina Solé, Susie Guilly, Kevin Da Silva, Marta Llopis, Emmanuelle Le-Chatelier, Patricia Huelin, Marta Carol, Rebeca Moreira, Núria Fabrellas, Gloria De Prada, Laura Napoleone, Isabel Graupera, Elisa Pose, Adrià Juanola, Natalia Borruel, Magali Berland, David Toapanta, Francesc Casellas, Francisco Guarner, Jöel Doré, Elsa Solà, Stanislav Dusko Ehrlich, Pere Ginès
Published in: Gastroenterology, Issue 160/1, 2021, Page(s) 206-218.e13, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.08.054

Molecular characterization of chronic liver disease dynamics: From liver fibrosis to acute-on-chronic liver failure.

Author(s): Graupera I, Isus L, Coll M, Pose E, Díaz A, Vallverdú J, Rubio-Tomás T, Martínez-Sánchez C, Huelin P, Llopis M, Solé C, Fondevila C, Lozano JJ, Sancho-Bru P, Ginès P, Aloy P.
Published in: JHEP Rep., Issue Apr 4;4(6):, 2022, Page(s) 100482
Publisher: National Library of Medicine
DOI: 10.1016/j.jhepr.2022.100482

Acute-on-chronic liver failure: an update

Author(s): Ruben Hernaez, Elsa Solà, Richard Moreau, Pere Ginès
Published in: Gut, Issue 66/3, 2017, Page(s) 541-553, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312670

Hepatorenal syndrome in the era of acute kidney injury

Author(s): Cristina Solé, Elisa Pose, Elsa Solà, Pere Ginès
Published in: Liver International, 2018, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.13893

Statins: old drugs as new therapy for liver diseases?

Author(s): Elisa Pose, Jonel Trebicka, Rajeshwar P. Mookerjee, Paolo Angeli, Pere Ginès
Published in: Journal of Hepatology, 2018, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.07.019

Nursing care of patients with cirrhosis

Author(s): Núria Fabrellas, Marta Carol, Ester Palacio, Marites Aban, Tommaso Lanzillotti, Gea Nicolao, Maria Teresa Chiappe, Vanessa Esnault, Sabine Graf‐Dirmeier, Jeltje Helder, Andrea Gossard, Mireia Lopez, Marta Cervera, Lacey L. Dols, Elsa Solà, Elisa Pose, Paolo Caraceni, Victor Vargas, Carlo Alessandria, Ulrich Beuers, Jonel Trebicka, François Durand, Rajeshwar Mookerjee, Paolo Angeli, Marko Kore
Published in: Hepatology, 2020, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31117

Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival

Author(s): Cristina Solé, Elsa Solà, Patricia Huelin, Marta Carol, Rebeca Moreira, Unai Cereijo, José‐Manuel Mas, Isabel Graupera, Elisa Pose, Laura Napoleone, Gloria dePrada, Adrià Juanola, Núria Fabrellas, Ferran Torres, Manuel Morales‐Ruiz, Judith Farrés, Wladimiro Jiménez, Pere Ginès
Published in: Liver International, Issue 39/7, 2019, Page(s) 1246-1255, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14037

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Author(s): Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Published in: PLOS ONE, Issue 15/4, 2020, Page(s) e0231701, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0231701

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Author(s): Jonel Trebicka, Wenyi Gu, Victor de Ledinghen, Christophe Aubé, Aleksander Krag, Michael Praktiknjo, Laurent Castera, Jerome Dumortier, David Josef Maria Bauer, Mireen Friedrich-Rust, Stanislas Pol, Ivica Grgurevic, Rongqin Zheng, Sven Francque, Halima Gottfriedovà, Sanda Mustapic, Ioan Sporea, Annalisa Berzigotti, Frank Erhard Uschner, Benedikt Simbrunner, Maxime Ronot, Christophe Cassinotto, M
Published in: Gut, 2021, Page(s) gutjnl-2020-323419, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323419

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Author(s): Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Published in: Gut, Issue 69/8, 2020, Page(s) 1535-1536, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319044

Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial.

Author(s): Elisa Pose; Laura Napoleone; Ahmed Al Amin; Daniela Campion; Cesar Jimenez; Salvatore Piano; Olivier Roux; Frank Erhard Uschner; Frank Erhard Uschner; Koos de Wit; Giacomo Zaccherini; Carlo Alessandria; Paolo Angeli; Mauro Bernardi; Ulrich Beuers; Paolo Caraceni; François Durand; Rajeshwar P. Mookerjee; Jonel Trebicka; Victor Vargas; Raúl J. Andrade; Marta Carol; Judit Pich; Juan Ferrero; Gema D
Published in: lancet. Gastroenterology & hepatology, 5(1), 31 - 41. Elsevier Limited, Issue 1, 2020, Page(s) 31-41
Publisher: -
DOI: 10.1016/s2468-1253(19)30320-6

Cardiodynamic state is associated with systemic inflammation and fatal acute‐on‐chronic liver failure

Author(s): Michael Praktiknjo, Sofia Monteiro, Josephine Grandt, Nina Kimer, Jan L. Madsen, Mikkel P. Werge, Peter William, Maximilian J. Brol, Laura Turco, Robert Schierwagen, Johannes Chang, Sabine Klein, Frank E. Uschner, Christoph Welsch, Richard Moreau, Filippo Schepis, Flemming Bendtsen, Lise L. Gluud, Søren Møller, Jonel Trebicka
Published in: Liver International, Issue 40/6, 2020, Page(s) 1457-1466, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14433

The search for disease-modifying agents in decompensated cirrhosis: From drug repurposing to drug discovery.

Author(s): Paolo Caraceni, Juan G Abraldes, Pere Ginès, Phil N Newsome, Shiv K Sarin.
Published in: J Hepatol, Issue 75 Suppl 1, 2021, Page(s) S118-S134, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.01.024

Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids

Author(s): Koos de Wit , Ulrich Beuers, Anna Mukha, Edwin C A Stigter, M Can Gulersonmez, Jose M Ramos Pittol, Sabine Middendorp, R Bart Takkenberg, Saskia W C van Mil
Published in: Liver Int, Issue 43(3), 2023, Page(s) 649-659
Publisher: -
DOI: 10.1111/liv.15491

The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells

Author(s): Nadine Bachtler, Sandra Torres, Cristina Ortiz, Robert Schierwagen, Olaf Tyc, Christoph Hieber, Marie-Luise Berres, Caroline Meier, Nico Kraus, Stefan Zeuzem, Bart Nijmeijer, Sebas Pronk, Jonel Trebicka, Sabine Klein
Published in: PLoS One, Issue 18(1), 2023, Page(s) e0270288
Publisher: -
DOI: 10.1371/journal.pone.0270288

The rationale and study design of two phase II trials examining the efects of BI 685,509,a soluble guanylyl cyclase activator, on clinicallysignifcant portal hypertension in patientswith compensated cirrhosis

Author(s): Reiberger T, Berzigotti A, Trebicka J, Ertle J, Gashaw I, Swallow R, Tomisser A.
Published in: Trials, Issue Apr 24;24(1), 2023, Page(s) 293
Publisher: Springer Nature
DOI: 10.1186/s13063-023-07291-3

Stigmatization is common in patients with non-alcoholic fatty liver disease and correlates with quality of life

Author(s): Marta Carol, Martina Pérez-Guasch, Elsa Solà, Marta Cervera, Sara Martínez, Adrià Juanola, Ann T Ma, Emma Avitabile, Laura Napoleone, Elisa Pose, Isabel Graupera, Maria Honrubia, Marko Korenjak, Ferran Torres, Pere Ginès, Núria Fabrellas; LiverHope Consortium Investigators
Published in: PLoS One, Issue 6;17(4), 2022, Page(s) e0265153, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0265153

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Author(s): Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Published in: Liver Transplantation, Issue 26/7, 2020, Page(s) 906-915, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25788

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Author(s): Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Published in: Journal of Clinical Medicine, Issue 8/4, 2019, Page(s) 419, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8040419

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