Objectif Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design. However, this potential has not been realised, because it requires developing and integrating disparate technologies to measure and manipulate mechanical and adhesive properties from the nanometre to the metre scale. We propose to address this challenge by building an interdisciplinary research community with the aim of understanding and controlling cellular mechanics from the molecular to the organism scale. At the nanometric molecular level, we will develop cellular microenvironments enabled by peptidomimetics of cell-cell and cell-matrix ligands, with defined mechanical and adhesive properties that we will dynamically control in time and space trough photo-activation. The properties under force of the molecular bonds involved will be characterized using single-molecule atomic force microscopy and magnetic tweezers. At the cell-to-organ scale, we will combine controlled microenvironments and interfering strategies with the development of techniques to measure and control mechanical forces and adhesion in cells and tissues, and to evaluate their biological response. At the organism scale, we will establish how cellular mechanics can be controlled, by targeting specific adhesive interactions, to impair or abrogate breast tumour progression in a mouse model. At all stages and scales of the project, we will integrate experimental data with multi-scale computational modelling to establish the rules driving biological response to mechanics and adhesion. With this approach, we aim to develop specific therapeutic approaches beyond the current paradigm in breast cancer treatment. Beyond breast cancer, the general principles targeted by our technology will have high applicability in oncology, regenerative medicine and biomaterials. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologynatural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicineoncologybreast cancernatural sciencesbiological sciencesbiophysics Mots‑clés mechanobiology biophysics integrins cadherins chemical biology AFM nanotechnology hydrogels traction force microscopy photo-activation breast cancer multi scale modelling single molecule Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.2. - FET Proactive Thème(s) FETPROACT-01-2016 - FET Proactive: emerging themes and communities Appel à propositions H2020-FETPROACT-2016-2017 Voir d’autres projets de cet appel Sous appel FETPROACT-2016 Régime de financement RIA - Research and Innovation action Coordinateur FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Contribution nette de l'UE € 1 952 419,59 Adresse CARRER BALDIRI REIXAC PLANTA 2A 10-12 08028 Barcelona Espagne Voir sur la carte Région Este Cataluña Barcelona Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 952 419,59 Participants (6) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire UNIVERSITAT POLITECNICA DE CATALUNYA Espagne Contribution nette de l'UE € 638 000,00 Adresse CALLE JORDI GIRONA 31 08034 Barcelona Voir sur la carte Région Este Cataluña Barcelona Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 638 000,00 LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH Allemagne Contribution nette de l'UE € 829 567,32 Adresse CAMPUS D2 2 66123 Saarbruecken Voir sur la carte Région Saarland Saarland Regionalverband Saarbrücken Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 829 567,32 KING'S COLLEGE LONDON Royaume-Uni Contribution nette de l'UE € 706 715,00 Adresse STRAND WC2R 2LS London Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 706 715,00 UNIVERSITAIR MEDISCH CENTRUM UTRECHT Pays-Bas Contribution nette de l'UE € 2 424 950,00 Adresse HEIDELBERGLAAN 100 3584 CX Utrecht Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 2 424 950,00 MIND THE BYTE SL Participation terminée Espagne Contribution nette de l'UE € 127 844,16 Adresse CALLE MANSO 76 PRINCIPAL 1 08015 Barcelona Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Este Cataluña Barcelona Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 127 844,16 NOVIOCELL BV Participation terminée Pays-Bas Contribution nette de l'UE € 455 432,68 Adresse KLOOSTERSTRAAT 9 RE1131 5349 AB Oss Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 455 432,68