Mechanical control of biological function | MECHANO-CONTROL | Projet | Résultats | H2020 | CORDIS

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Plan for the Exploitation and Dissemination of Results
Characterization of mechanical and adhesive factors driving sub-cellular behaviour

Characterization of mechanical and adhesive factors driving sub-cellular behaviour, plus publication

Updated Plan for the Exploitation and Dissemination of Results M12

Update the Plan for the Exploitation and Dissemination of Results

Characterization of mechanical and adhesive factors driving cellular behaviour

Characterization of mechanical and adhesive factors driving cellular behaviour, plus publication.

Updated Plan for the Exploitation and Dissemination of Results M48

Update the Plan for the Exploitation and Dissemination of Results

Proof of concept tested and publication: human breast cancer xenografts can be treated/controlled by controlling tissue mechanics

Proof of concept tested and publication human breast cancer xenografts can be treatedcontrolled by controlling tissue mechanics

Proof of concept tested and publication: transplantation-based syngeneic mouse breast cancer model can be treated/controlled by controlling tissue mechanics

Proof of concept tested and publication transplantationbased syngeneic mouse breast cancer model can be treatedcontrolled by controlling tissue mechanics

Updated Plan for the Exploitation and Dissemination of Results M30

Update the Plan for the Exploitation and Dissemination of Results

Proof of concept tested and publication: mechanical-control can enhance the efficacy of current breast cancer treatments

Proof of concept tested and publication mechanicalcontrol can enhance the efficacy of current breast cancer treatments

Updated Plan for the Exploitation and Dissemination of Results M60

Update the Plan for the Exploitation and Dissemination of Results

Characterization of mechanical and adhesive factors driving monolayer behaviour

Characterization of mechanical and adhesive factors driving monolayer behaviour plus publication

Characterization of mechanical and adhesive factors driving organoid behaviour

Characterization of mechanical and adhesive factors driving organoid behaviour plus publication

Set-up of the continuum model coupling adhesion, cortex, membrane and matrix
Cohesive traction-separation law based on cell doublet data and detailed modeling, and new modeling-based quantitative protocols of adhesion based on spreading

Cohesive traction-separation law based on cell doublet data and detailed modeling, and new modeling-based quantitative protocols of adhesion based on spreading.

Set-up of the specific validation experiments for bond clusters, and Predictive models for the lifetime of a cluster
Set-up of the discrete stochastic models for bond clusters

Summer school
Logo and Public website of the project
Mechanobiology Meeting

Publications

Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility

Auteurs: Chiara Zambarda, Carlos Perez Gonzalez, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat , Elisabetta Ada Cavalcanti-Adam
Publié dans: European Journal of Cell Biology, 2022, ISSN 0171-9335
Éditeur: Elsevier BV
DOI: 10.1016/j.ejcb.2022.151274

Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system

Auteurs: Lolo FN, Walani N, Seemann E, Zalvidea D, Pavón DM, Cojoc G, Zamai M, Viaris de Lesegno C, Martínez de Benito F, Sánchez-Álvarez M, Uriarte JJ, Echarri A, Jiménez-Carretero D, Escolano JC, Sánchez SA, Caiolfa VR, Navajas D, Trepat X, Guck J, Lamaze C, Roca-Cusachs P, Kessels MM, Qualmann B, Arroyo M, Del Pozo MA.
Publié dans: Nature Cell Biology, 2022, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-022-01034-3

Digesting the mechanobiology of the intestinal epithelium

Auteurs: Carlos Pérez-González, Gerardo Ceada, Marija Matejčić, Xavier Trepat
Publié dans: Current Opinion in Genetics & Development, 2021, ISSN 0959-437X
Éditeur: Elsevier BV
DOI: 10.1016/j.gde.2021.10.005

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Auteurs: Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gomez-Gonzalez, Laura M. Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarne, David Barata, Isabela C. Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, and Claudio A. Franco
Publié dans: Developmental Cell, 2022, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Auteurs: Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo & Pere Roca-Cusachs
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-26591-3

Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation

Auteurs: Julieta I. Paez, Aleeza Farrukh, Rocío Valbuena-Mendoza, Małgorzata K. Włodarczyk-Biegun, Aránzazu del Campo
Publié dans: ACS Applied Materials & Interfaces, Numéro 12/7, 2020, Page(s) 8062-8072, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.0c00709

Positive, negative and controlled durotaxis

Auteurs: Sáez Viñas, Pablo; Venturini, Chiara
Publié dans: Soft Matter, 2023, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2sm01326f

Cardiac fibroblasts and mechanosensation in heart development, health and disease

Auteurs: Maurizio Pesce, Georg N. Duda, Giancarlo Forte, Henrique Girao, Angel Raya, Pere Roca-Cusachs, Joost P. G. Sluijter, Carsten Tschöpe & Sophie Van Linthout
Publié dans: Nature Review Cardiology, 2022, ISSN 1759-5002
Éditeur: Nature Publishing Group
DOI: 10.1038/s41569-022-00799-2

Stiffness-dependent active wetting enables optimal collective cell durotaxis

Auteurs: Macià Esteve Pallarès, Irina Pi-Jaumà, Isabela Corina Fortunato, Valeria Grazu, Manuel Gómez-González, Pere Roca-Cusachs, Jesus M. de la Fuente, Ricard Alert, Raimon Sunyer, Jaume Casademunt & Xavier Trepat
Publié dans: Nature Physics, 2022, ISSN 1745-2473
Éditeur: Nature Publishing Group
DOI: 10.1038/s41567-022-01835-1

An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity

Auteurs: Jooske L. Monster, Lisa Donker, Marjolein J. Vliem, Zaw Win, Helen K. Matthews, Joleen S. Cheah, Soichiro Yamada, Johan de Rooij, Buzz Baum, Martijn Gloerich
Publié dans: Journal of Cell Biology, Numéro 220/5, 2021, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.202001042

Active wetting of epithelial tissues

Auteurs: Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt, Xavier Trepat
Publié dans: Nature Physics, Numéro 15/1, 2019, Page(s) 79-88, ISSN 1745-2473
Éditeur: Nature Publishing Group
DOI: 10.1038/s41567-018-0279-5

Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking

Auteurs: Dimitri Kaurin, Pradeep K. Bal, Marino Arroyo
Publié dans: Journal of the Royal Society Interface, 2022, ISSN 1742-5689
Éditeur: The Royal Society
DOI: 10.1098/rsif.2022.0183

Mechanical force application to the nucleus regulates nucleocytoplasmic transport

Auteurs: Ion Andreu, Ignasi Granero-Moya, Nimesh R. Chahare, Kessem Clein, Marc Molina-Jordán, Amy E. M. Beedle, Alberto Elosegui-Artola, Juan F. Abenza, Leone Rossetti, Xavier Trepat, Barak Raveh, Pere Roca-Cusachs
Publié dans: Nature Cell Biology, 2022, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-022-00927-7

A theory of ordering of elongated and curved proteins on membranes driven by density and curvature

Auteurs: Caterina Tozzi, Nikhil Walani, Anabel-Lise Le Roux, Pere Roca-Cusachs, Marino Arroyo
Publié dans: Soft Matter, Numéro 17/12, 2021, Page(s) 3367-3379, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0sm01733g

Thiol-Methylsulfone-Based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-Methylsulfone Substrate for Fine-Tunable Gelation Rate and Improved Stability

Auteurs: Julieta I. Paez, Adrián de Miguel-Jiménez, Rocío Valbuena-Mendoza, Aditi Rathore, Minye Jin, Alisa Gläser, Samuel Pearson, Aránzazu del Campo
Publié dans: Biomacromolecules, 2021, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.1c00256

Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations

Auteurs: Andrew Stannard, Marc Mora, Amy E. M. Beedle, Marta Castro-López, Stephanie Board, Sergi Garcia-Manyes
Publié dans: Nano Letters, Numéro 21/7, 2021, Page(s) 2953-2961, ISSN 1530-6984
Éditeur: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00051

TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity

Auteurs: Gallego-Paez, L. M., Edwards, W. J. S., Chanduri, M., Guo, Y., Koorman, T., Lee, C. Y., Grexa, N., Derksen, P., Yan, J., Schwartz, M. A., Mauer, J., & Goult, B. T.
Publié dans: Journal of Cell Biology, 2023, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.202209010

Mechanical strain stimulates COPII‐dependent secretory trafficking via Rac1

Auteurs: Santosh Phuyal, Elena Djaerff, Anabel-Lise Le Roux, Martin J Baker, Daniela Fankhauser, Sayyed Jalil Mahdizadeh, Veronika Reiterer, Amirabbas Parizadeh, Edward Felder,Jennifer C Kahlhofer, David Teis, Marcelo G Kazanietz, Stephan Geley, Leif Eriksson, Pere Roca-Cusachs & Hesso Farhan
Publié dans: EMBO Journal, 2022, ISSN 1460-2075
Éditeur: Wiley-Blackwell
DOI: 10.15252/embj.2022110596

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

Auteurs: George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V. Lee, Jos Jonkers, Valerie G. Brunton, Matthias Christgen, Clare Isacke, Patrick W. B. Derksen, and Cathrin Brisken
Publié dans: Cancers, 2021, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215396

Optoregulated force application to cellular receptors using molecular motors

Auteurs: Yijun Zheng, Mitchell K. L. Han, Renping Zhao, Johanna Blass, Jingnan Zhang, Dennis W. Zhou, Jean-Rémy Colard-Itté, Damien Dattler, Arzu Çolak, Markus Hoth, Andrés J. García, Bin Qu, Roland Bennewitz, Nicolas Giuseppone & Aránzazu del Campo
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-23815-4

SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

Auteurs: Sluimer, L. M., Bullock, E., Rätze, M. A. K., Enserink, L., Overbeeke, C., Hornsveld, M., Brunton, V. G., Derksen, P. W. B., & Tavares, S.
Publié dans: Journal of cell science, 2023, ISSN 0021-9533
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260243

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

Auteurs: Pérez-González C; Ceada G; Greco F; Matej?i? M; Gómez-González M; Castro N; Menendez A; Kale S; Krndija D; Clark AG; Gannavarapu VR; Álvarez-Varela A; Roca-Cusachs P; Batlle E; Vignjevic DM; Arroyo M; Trepat X
Publié dans: Nature Cell Biology, 2021, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-021-00699-6

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

Auteurs: Wallis SS, Ventimiglia, LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M
Publié dans: Developmental Cell, 2021, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2021.10.022

Understanding the role of mechanics in nucleocytoplasmic transport

Auteurs: Ion Andreu, Ignasi Granero-Moya, Sergi Garcia-Manyes and Pere Roca-Cusachs
Publié dans: APL Bioengineering, 2022, ISSN 2473-2877
Éditeur: American Institute of Physics
DOI: 10.1063/5.0076034

Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins

Auteurs: Caterina Tozzi, Nikhil Walani, Marino Arroyo
Publié dans: New Journal of Physics, Numéro 21/9, 2019, Page(s) 093004, ISSN 1367-2630
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ab3ad6

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Auteurs: Max A. K. Rätze, Thijs Koorman, Thijmen Sijnesael, Blessing Bassey-Archibong, Robert van de Ven, Lotte Enserink, Daan Visser, Sridevi Jaksani, Ignacio Viciano, Elvira R. M. Bakker, François Richard, Andrew Tutt, Lynda O’Leary, Amanda Fitzpatrick, Pere Roca-Cusachs, Paul J. van Diest, Christine Desmedt, Juliet M. Daniel, Clare M. Isacke and Patrick W. B. Derksen
Publié dans: Oncogene, 2022, ISSN 0950-9232
Éditeur: Nature Publishing Group
DOI: 10.1038/s41388-022-02314-w

Surface Tension Controls the Hydraulic Fracture of Adhesive Interfaces Bridged by Molecular Bonds

Auteurs: Dimitri Kaurin, Marino Arroyo
Publié dans: Physical Review Letters, Numéro 123/22, 2019, ISSN 0031-9007
Éditeur: American Physical Society
DOI: 10.1103/physrevlett.123.228102

Modelling fluid deformable surfaces with an emphasis on biological interfaces

Auteurs: Alejandro Torres-Sánchez, Daniel Millán, Marino Arroyo
Publié dans: Journal of Fluid Mechanics, Numéro 872, 2019, Page(s) 218-271, ISSN 0022-1120
Éditeur: Cambridge University Press
DOI: 10.1017/jfm.2019.341

Binding of anisotropic curvature-inducing proteins onto membrane tubes

Auteurs: Hiroshi Noguchi, Caterina Tozzi and Marino Arroyo
Publié dans: Soft Matter, 2022, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2sm00274d

Force transduction by cadherin adhesions in morphogenesis

Auteurs: Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich
Publié dans: F1000Research, Numéro 8, 2019, Page(s) 1044, ISSN 2046-1402
Éditeur: F1000 Research Ltd.
DOI: 10.12688/f1000research.18779.1

The 2020 motile active matter roadmap

Auteurs: Gerhard Gompper, Roland G Winkler, Thomas Speck, Alexandre Solon, Cesare Nardini, Fernando Peruani, Hartmut Löwen, Ramin Golestanian, U Benjamin Kaupp, Luis Alvarez, Thomas Kiørboe, Eric Lauga, Wilson C K Poon, Antonio DeSimone, Santiago Muiños-Landin, Alexander Fischer, Nicola A Söker, Frank Cichos, Raymond Kapral, Pierre Gaspard, Marisol Ripoll, Francesc Sagues, Amin Doostmohammadi, Julia M
Publié dans: Journal of Physics: Condensed Matter, Numéro 32/19, 2020, Page(s) 193001, ISSN 0953-8984
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-648x/ab6348

The mechanics of single cross-links which mediate cell attachment at a hydrogel surface

Auteurs: Arzu Çolak, Bin Li, Johanna Blass, Kaloian Koynov, Aranzazu del Campo, Roland Bennewitz
Publié dans: Nanoscale, Numéro 11/24, 2019, Page(s) 11596-11604, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9nr01784d

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion

Auteurs: Maria Villiou, Julieta I. Paez, Aránzazu del Campo
Publié dans: ACS Applied Materials & Interfaces, Numéro 12/34, 2020, Page(s) 37862-37872, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.0c08568

Rethinking organoid technology through bioengineering

Auteurs: Elena Garreta, Roger D. Kamm, Susana M. Chuva de Sousa Lopes, Madeline A. Lancaster, Ron Weiss, Xavier Trepat, Insoo Hyun, Nuria Montserrat
Publié dans: Nature Materials, Numéro 20/2, 2021, Page(s) 145-155, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/s41563-020-00804-4

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues

Auteurs: Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li, Jun Feng, Aránzazu del Campo
Publié dans: Materials Horizons, Numéro 7/1, 2020, Page(s) 111-116, ISSN 2051-6347
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9mh00665f

Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

Auteurs: Thijs Koorman, Karin A. Jansen, Antoine Khalil, Peter D. Haughton, Daan Visser, Max A. K. Rätze, Wisse E. Haakma, Gabrielè Sakalauskaitè, Paul J. van Diest, Johan de Rooij and Patrick W. B. Derksen
Publié dans: Oncogene, 2022, ISSN 0950-9232
Éditeur: Nature Publishing Group
DOI: 10.1038/s41388-022-02258-1

Toward Light-Regulated Living Biomaterials

Auteurs: Shrikrishnan Sankaran, Shifang Zhao, Christina Muth, Julieta Paez, Aránzazu del Campo
Publié dans: Advanced Science, Numéro 5/8, 2018, Page(s) 1800383, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.201800383

The nanomechanics of individual proteins

Auteurs: Marc Mora, Andrew Stannard, Sergi Garcia-Manyes
Publié dans: Chemical Society Reviews, Numéro 49/19, 2020, Page(s) 6816-6832, ISSN 0306-0012
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0cs00426j

Self-generated gradients steer collective migration on viscoelastic collagen networks

Auteurs: Andrew G. Clark, Ananyo Maitra, Cécile Jacques , Martin Bergert , Carlos Pérez-González, Anthony Simon, Luc Lederer , Alba Diz-Muñoz, Xavier Trepat, Raphaël Voituriez, Danijela Matic Vignjevic
Publié dans: Nature materials, 2022, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/s41563-022-01259-5

Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro

Auteurs: Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop, Aránzazu del Campo
Publié dans: BMC Molecular and Cell Biology, Numéro 21/1, 2020, ISSN 2661-8850
Éditeur: BioMed Central Ltd
DOI: 10.1186/s12860-020-00267-0

FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

Auteurs: Sandra Tavares, Nalan Liv, Milena Pasolli, Mark Opdam, Max A.K. Rätze, Manuel Saornil, Lilian M. Sluimer, Rutger C.C. Hengeveld, Robert van Es, Erik van Werkhoven, Harmjan Vos, Holger Rehmann, Boudewijn M.T. Burgering, Hendrika M. Oosterkamp, Susanne M.A. Lens, Judith Klumperman, Sabine C. Linn, Patrick W.B. Derksen
Publié dans: Cell reports, 2022, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.110584

αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer

Auteurs: Jolien S de Groot, Max AK Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet-Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick WB Derksen
Publié dans: The Journal of Pathology, Numéro 245/4, 2018, Page(s) 456-467, ISSN 0022-3417
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/path.5099

Near-infrared-light regulated angiogenesis in a 4D hydrogel

Auteurs: Yijun Zheng, Zhijun Chen, Qiyang Jiang, Jun Feng, Si Wu, Aránzazu del Campo
Publié dans: Nanoscale, Numéro 12/25, 2020, Page(s) 13654-13661, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0nr02552f

Physical Models of Collective Cell Migration

Auteurs: Ricard Alert, Xavier Trepat
Publié dans: Annual Review of Condensed Matter Physics, Numéro 11/1, 2020, Page(s) 77-101, ISSN 1947-5454
Éditeur: Annual Reviews Inc.
DOI: 10.1146/annurev-conmatphys-031218-013516

Long-lived force patterns and deformation waves at repulsive epithelial boundaries

Auteurs: Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat
Publié dans: Nature Materials, Numéro 16/10, 2017, Page(s) 1029-1037, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/NMAT4972

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

Auteurs: Alberto Elosegui-Artola, Ion Andreu, Amy E.M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes, Pere Roca-Cusachs
Publié dans: Cell, Numéro 171/6, 2017, Page(s) 1397-1410.e14, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2017.10.008

Membrane tension controls adhesion positioning at the leading edge of cells

Auteurs: Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, Nils C. Gauthier
Publié dans: The Journal of Cell Biology, 2017, Page(s) jcb.201611117, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.201611117

Force loading explains spatial sensing of ligands by cells

Auteurs: Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam, Pere Roca-Cusachs
Publié dans: Nature, 2017, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature24662

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links

Auteurs: Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González, Pere Roca-Cusachs
Publié dans: Molecular Biology of the Cell, Numéro 28/14, 2017, Page(s) 1847-1852, ISSN 1059-1524
Éditeur: American Society for Cell Biology
DOI: 10.1091/mbc.E17-01-0006

Amoebae as Mechanosensitive Tanks

Auteurs: Alberto Elosegui-Artola, Pere Roca-Cusachs
Publié dans: Biophysical Journal, Numéro 112/12, 2017, Page(s) 2457-2458, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2017.05.020

The force-dependent mechanism of DnaK-mediated mechanical folding

Auteurs: Judit Perales-Calvo, David Giganti, Guillaume Stirnemann, Sergi Garcia-Manyes
Publié dans: Science Advances, Numéro 4/2, 2018, Page(s) eaaq0243, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaq0243

Quantifying forces in cell biology

Auteurs: Pere Roca-Cusachs, Vito Conte, Xavier Trepat
Publié dans: Nature Cell Biology, Numéro 19/7, 2017, Page(s) 742-751, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/ncb3564

Molecular clutch drives cell response to surface viscosity

Auteurs: Mark Bennett, Marco Cantini, Julien Reboud, Jonathan M. Cooper, Pere Roca-Cusachs, Manuel Salmeron-Sanchez
Publié dans: Proceedings of the National Academy of Sciences, Numéro 115/6, 2018, Page(s) 1192-1197, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1710653115

Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces

Auteurs: Anna Labernadie, Xavier Trepat
Publié dans: Current Opinion in Cell Biology, Numéro 54, 2018, Page(s) 57-65, ISSN 0955-0674
Éditeur: Elsevier BV
DOI: 10.1016/j.ceb.2018.04.008

4D Biomaterials for Light‐Guided Angiogenesis

Auteurs: Aleeza Farrukh, Julieta I. Paez, Aránzazu del Campo
Publié dans: Advanced Functional Materials, Numéro 29/6, 2019, Page(s) 1807734, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201807734

Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis

Auteurs: Adam Shellard, András Szabó, Xavier Trepat, Roberto Mayor
Publié dans: Science, Numéro 362/6412, 2018, Page(s) 339-343, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aau3301

Active superelasticity in three-dimensional epithelia of controlled shape

Auteurs: Ernest Latorre, Sohan Kale, Laura Casares, Manuel Gómez-González, Marina Uroz, Léo Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, Aránzazu del Campo, Benoit Ladoux, Marino Arroyo, Xavier Trepat
Publié dans: Nature, Numéro 563/7730, 2018, Page(s) 203-208, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-018-0671-4

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells

Auteurs: Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P. Singh, Marta C. Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A. del Pozo, Robert G. Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-06738-5

Forcing the reversibility of a mechanochemical reaction

Auteurs: Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann, Sergi Garcia-Manyes
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-05115-6

In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV

Auteurs: Aleeza Farrukh, Shifang Zhao, Julieta I. Paez, Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalié, Aránzazu del Campo
Publié dans: ACS Applied Materials & Interfaces, Numéro 10/48, 2018, Page(s) 41129-41137, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.8b15517

A hybrid computational model for collective cell durotaxis

Auteurs: Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel García-Aznar
Publié dans: Biomechanics and Modeling in Mechanobiology, Numéro 17/4, 2018, Page(s) 1037-1052, ISSN 1617-7959
Éditeur: Springer Verlag
DOI: 10.1007/s10237-018-1010-2

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer

Auteurs: Heather C. Bruner, Patrick W.B. Derksen
Publié dans: Cold Spring Harbor Perspectives in Biology, Numéro 10/3, 2018, Page(s) a029330, ISSN 1943-0264
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a029330

Re-inforcing the cell death army in the fight against breast cancer

Auteurs: Clara R. L. Oudenaarden, Robert A. H. van de Ven, Patrick W. B. Derksen
Publié dans: Journal of Cell Science, Numéro 131/16, 2018, Page(s) jcs212563, ISSN 0021-9533
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/jcs.212563

Mesoscale physical principles of collective cell organization

Auteurs: Xavier Trepat, Erik Sahai
Publié dans: Nature Physics, Numéro 14/7, 2018, Page(s) 671-682, ISSN 1745-2473
Éditeur: Nature Publishing Group
DOI: 10.1038/s41567-018-0194-9

DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43

Auteurs: Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann, Sergi Garcia-Manyes
Publié dans: The Journal of Physical Chemistry Letters, Numéro 9/14, 2018, Page(s) 3800-3807, ISSN 1948-7185
Éditeur: American Chemical Society
DOI: 10.1021/acs.jpclett.8b01494

A Photoactivatable α 5 β 1 -Specific Integrin Ligand

Auteurs: Roshna V. Nair, Aleeza Farrukh, Aránzazu del Campo
Publié dans: ChemBioChem, Numéro 19/12, 2018, Page(s) 1280-1287, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800180

Control of Mechanotransduction by Molecular Clutch Dynamics

Auteurs: Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs
Publié dans: Trends in Cell Biology, Numéro 28/5, 2018, Page(s) 356-367, ISSN 0962-8924
Éditeur: Elsevier BV
DOI: 10.1016/j.tcb.2018.01.008

Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth

Auteurs: Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aránzazu del Campo
Publié dans: ChemBioChem, Numéro 19/12, 2018, Page(s) 1271-1279, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800118

Regulation of cell cycle progression by cell–cell and cell–matrix forces

Auteurs: Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà, Xavier Trepat
Publié dans: Nature Cell Biology, Numéro 20/6, 2018, Page(s) 646-654, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-018-0107-2

Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms

Auteurs: Nils C Gauthier, Pere Roca-Cusachs
Publié dans: Current Opinion in Cell Biology, Numéro 50, 2018, Page(s) 20-26, ISSN 0955-0674
Éditeur: Elsevier BV
DOI: 10.1016/j.ceb.2017.12.014

TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4

Auteurs: Arthur J. Kuipers, Jeroen Middelbeek, Kirsten Vrenken, Carlos Pérez-González, Geert Poelmans, Jeffrey Klarenbeek, Kees Jalink, Xavier Trepat, Frank N. van Leeuwen
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numéro 1864/7, 2018, Page(s) 2409-2419, ISSN 0925-4439
Éditeur: Elsevier BV
DOI: 10.1016/j.bbadis.2018.04.017

Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly

Auteurs: Essak S. Khan, Shrikrishnan Sankaran, Julieta I. Paez, Christina Muth, Mitchell K. L. Han, Aránzazu del Campo
Publié dans: Advanced Science, Numéro 6/9, 2019, Page(s) 1801982, ISSN 2198-3844
Éditeur: WILEY-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/advs.201801982

Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium

Auteurs: Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna Marín-Llauradó, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ángel Raya, Xavier Trepat
Publié dans: Nature Materials, 2019, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/s41563-019-0381-9

The plasma membrane as a mechanochemical transducer

Auteurs: Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs
Publié dans: Philosophical Transactions of the Royal Society B: Biological Sciences, Numéro 374/1779, 2019, Page(s) 20180221, ISSN 0962-8436
Éditeur: Royal Society of London
DOI: 10.1098/rstb.2018.0221

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness

Auteurs: Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt
Publié dans: Acta Biomaterialia, Numéro 87, 2019, Page(s) 256-264, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2019.01.063

The mechanical stability of proteins regulates their translocation rate into the cell nucleus

Auteurs: Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs, Sergi Garcia-Manyes
Publié dans: Nature Physics, 2019, ISSN 1745-2473
Éditeur: Nature Publishing Group
DOI: 10.1038/s41567-019-0551-3

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

Auteurs: Elena Garreta, Patricia Prado, Carolina Tarantino, Roger Oria, Lucia Fanlo, Elisa Martí, Dobryna Zalvidea, Xavier Trepat, Pere Roca-Cusachs, Aleix Gavaldà-Navarro, Luca Cozzuto, Josep M. Campistol, Juan Carlos Izpisúa Belmonte, Carmen Hurtado del Pozo, Nuria Montserrat
Publié dans: Nature Materials, Numéro 18/4, 2019, Page(s) 397-405, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/s41563-019-0287-6

Integrins as biomechanical sensors of the microenvironment

Auteurs: Jenny Z. Kechagia, Johanna Ivaska, Pere Roca-Cusachs
Publié dans: Nature Reviews Molecular Cell Biology, Numéro 20/8, 2019, Page(s) 457-473, ISSN 1471-0072
Éditeur: Nature Publishing Group
DOI: 10.1038/s41580-019-0134-2

Cadherin mechanotransduction in leader-follower cell specification during collective migration

Auteurs: Antoine A. Khalil, Johan de Rooij
Publié dans: Experimental Cell Research, Numéro 376/1, 2019, Page(s) 86-91, ISSN 0014-4827
Éditeur: Academic Press
DOI: 10.1016/j.yexcr.2019.01.006

The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division

Auteurs: Christina L. Dix, Helen K. Matthews, Marina Uroz, Susannah McLaren, Lucie Wolf, Nicholas Heatley, Zaw Win, Pedro Almada, Ricardo Henriques, Michael Boutros, Xavier Trepat, Buzz Baum
Publié dans: Developmental Cell, Numéro 45/1, 2018, Page(s) 132-145.e3, ISSN 1534-5807
Éditeur: Cell Press
DOI: 10.1016/j.devcel.2018.03.009

Gelation Kinetics and Mechanical Properties of Thiol‐Tetrazole Methylsulfone Hydrogels Designed for Cell Encapsulation

Auteurs: Adrián de Miguel-Jiménez, Bastian Ebeling, Julieta I. Paez, Claudia Fink-Straube, Samuel Pearson, Aránzazu del Campo
Publié dans: Macromolecular Bioscience, 2022, ISSN 1616-5195
Éditeur: Wiley-VCH Verlag
DOI: 10.1002/mabi.202200419

Elastomeric Optical Waveguides by Extrusion Printing

Auteurs: Jun Feng, Yijun Zheng, Qiyang Jiang, Małgorzata K. Włodarczyk-Biegun, Samuel Pearson, and Aránzazu del Campo
Publié dans: Advanced Materials Technologies, 2022, ISSN 2365-709X
Éditeur: Wiley-Blackwell
DOI: 10.1002/admt.202101539

Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo

Auteurs: Samuel Pearson; Jun Feng; Jun Feng; Aránzazu del Campo; Aránzazu del Campo
Publié dans: Advanced Functional Materials, Numéro 7, 2021, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202105989

Embryonic self-fracking

Auteurs: Marino Arroyo, Xavier Trepat
Publié dans: Science, Numéro 365/6452, 2019, Page(s) 442-443, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aay2860

Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape

Auteurs: Tapia-Rojo, R; Mora, M; Board, S.J.; Walker, J; Boujemaa-Paterski, R.; Medalia, O; Garcia-Manyes, S.
Publié dans: Nature Physics, 2022, ISSN 1745-2473
Éditeur: Nature Publishing Group
DOI: 10.1038/s41567-022-01808-4

The role of single-protein elasticity in mechanobiology

Auteurs: Amy E. M. Beedle, Sergi Garcia-Manyes
Publié dans: Nature Review Materials, 2022, ISSN 2058-8437
Éditeur: Nature Publishing Group
DOI: 10.1038/s41578-022-00488-z

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

Auteurs: Donker L, Houtekamer R, Vliem M, Sipieter F, Canever H, Gómez-González M, Bosch-Padrós M, Pannekoek WJ, Trepat X, Borghi N, Gloerich M.
Publié dans: Cell Reports, 2022, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.111475

Protein nanomechanics: The power of stretching

Auteurs: Marc Mora, Sergi Garcia-Manyes
Publié dans: Europhysics News, Numéro 51/5, 2020, Page(s) 24-27, ISSN 0531-7479
Éditeur: European Physical Society
DOI: 10.1051/epn/2020503

LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice

Auteurs: Eline J. ter Steege; Thijmen Sijnesael; Lotte Enserink; Sjoerd Klarenbeek; Wisse E. Haakma; Elvira R.M. Bakker; Patrick W.B. Derksen
Publié dans: Neoplasia, 2022, ISSN 1522-8002
Éditeur: Elsevier BV
DOI: 10.1016/j.neo.2022.100844

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions

Auteurs: Danielle Park, Esther Wershof, Stefan Boeing, Anna Labernadie, Robert P. Jenkins, Samantha George, Xavier Trepat, Paul A. Bates, Erik Sahai
Publié dans: Nature Materials, Numéro 19/2, 2020, Page(s) 227-238, ISSN 1476-1122
Éditeur: Nature Publishing Group
DOI: 10.1038/s41563-019-0504-3

A Single-Molecule Strategy to Capture Non-native Intramolecular and Intermolecular Protein Disulfide Bridges

Auteurs: Marc Mora, Stephanie Board, Olivier Languin-Cattoën, Laura Masino, Guillaume Stirnemann, Sergi Garcia-Manyes
Publié dans: Nano Letters, 2022, ISSN 1530-6984
Éditeur: American Chemical Society
DOI: 10.1021/acs.nanolett.2c00043

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Auteurs: Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros & Pere Roca-Cusachs
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-24383-3

Possibilities and Limitations of Photoactivatable Cytochalasin D for the Spatiotemporal Regulation of Actin Dynamics

Auteurs: Roshna V. Nair, Shifang Zhao, Emmanuel Terriac, Franziska Lautenschläger, Joseph H.R. Hetmanski, Patrick T. Caswell, Aranzazu del Campo
Publié dans: ChemRxiv, 2020, ISSN 2573-2293
Éditeur: ChemRxiv
DOI: 10.26434/chemrxiv.12609545.v1

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