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Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Objetivo

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.

Convocatoria de propuestas

H2020-FETPROACT-2016-2017

Consulte otros proyectos de esta convocatoria

Convocatoria de subcontratación

FETPROACT-2016

Coordinador

UNIVERSITY OF BATH
Aportación neta de la UEn
€ 1 548 936,25
Dirección
Claverton Down
BA2 7AY Bath
United Kingdom
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de fuera de la UE
€ 0,00
Región
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire

Participantes (7)

UNIVERSITY OF BRISTOL

La participación finalizó

United Kingdom
Aportación neta de la UEn
€ 431 668,75
Dirección
Beacon House Queens Road
BS8 1QU Bristol
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de fuera de la UE
€ 0,00
Región
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
UNIVERSITAT ZURICH
Suiza
Aportación neta de la UEn
€ 833 367,50
Dirección
Ramistrasse 71
8006 Zurich
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de fuera de la UE
€ 0,00
MICROCHIP TECHNOLOGY CALDICOT LIMITED
United Kingdom
Aportación neta de la UEn
€ 403 125,00
Dirección
Phase 2 Castlegate Business Park
NP26 5YW Gwent
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Aportación de fuera de la UE
€ 0,00
Región
Wales East Wales Monmouthshire and Newport
 
MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Países Bajos
Aportación neta de la UEn
€ 550 000,00
Dirección
Endepolsdomein 5
6229GW Maastricht
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Aportación de fuera de la UE
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Aportación neta de la UEn
€ 584 375,00
Dirección
Spitalgasse 23
1090 Wien
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de fuera de la UE
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Países Bajos
Aportación neta de la UEn
€ 490 625,00
Dirección
Heidelberglaan 100
3584 CX Utrecht
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de fuera de la UE
€ 0,00
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Chequia
Aportación neta de la UEn
€ 102 250,00
Dirección
Pekarska 53
656 91 Brno
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de fuera de la UE
€ 0,00