Objetivo
This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.
Ámbito científico
- ciencias médicas y de la saludmedicina básicaneurologíaepilepsia
- ciencias médicas y de la saludmedicina clínicacardiologíaenfermedad cardiovasculararritmia cardíaca
- ciencias médicas y de la saludmedicina básicaneurologíaparkinson
- ciencias médicas y de la saludbiotecnología médicaimplantes
- ciencias naturalesinformática y ciencias de la informacióninteligencia artificialinteligencia computacional
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
FETPROACT-2016
Régimen de financiación
RIA - Research and Innovation action
Coordinador
BA2 7AY Bath
United Kingdom
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Participantes (7)
La participación finalizó
BS8 1QU Bristol
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8006 Zurich
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NP26 5YW Gwent
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6229GW Maastricht
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1090 Wien
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3584 CX Utrecht
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656 91 Brno
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