Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Project Information

CResPace

Grant agreement ID: 732170

DOI 10.3030/732170

Project closed

EC signature date 27 October 2016

Start date 1 January 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 4 944 347,50

EU contribution € 4 944 347,50

Coordinated by

UNIVERSITY OF BATH
United Kingdom

Deliverables

Documents, reports (7)

Data management plan

D10.2: Data management plan

Results of pacemaker trials in dog hearts with AV-block - publications

D92 Results of pacemaker trials in dog hearts with AVblock publications

Regulatory compliance report of the adaptive pacemaker

D93 Regulatory compliance report of the adaptive pacemaker

Report and publications on the benefits of restoring adaptive respiratory sinus arrhythmia in rodents with induced heart failure

D3.1: Report and publications on the benefits of restoring adaptive respiratory sinus arrhythmia in rodents with induced heart failure

Results of pacemaker trials in pig hearts with LBB-block - publications

D91 Results of pacemaker trials in pig hearts with LBBblock publications

Consortium website and logo

D10.1: Consortium website and logo

A database of electrocardiograms, arterial O2, CO2, lung inflation and blood pressure time series recordings for dog and pigs in states ranging from rest to intense activity

D4.1: A database of electrocardiograms, arterial O2, CO2, lung inflation and blood pressure time series recordings for dog and pigs in states ranging from rest to intense activity

Open Research Data Pilot (1)

Open Access

Copies of all consortium publications will be posted online after eventual embargo periods They will be freely accessible to the public primarily through OPUS opusbathacuk but also ArXiv and OpenAire

Other (5)

Universal VLSI circuit models for gate variables and gate recovery times

D2.1: Universal VLSI circuit models for gate variables and gate recovery times

Evaluation of safety envelope of the resynchronisation CPG, publications

D6.1: Evaluation of safety envelope of the resynchronisation CPG, publications

A database of electrophysiological recordings of respiratory neurons

D1.1: A database of electrophysiological recordings of respiratory neurons

Showcase conference abstract book

D10.6: Showcase conference abstract book

Model of the mammalian respiratory CPG

D1.2: Model of the mammalian respiratory CPG

Publications

Peer reviewed articles (13)

) Local inhibitory networks support up to (N − 1)!/ln2N limit cycles in the presence of electronic noise and heterogeneity

Author(s): A. Chauhan, J. Taylor, A. Nogaret
Published in: Physical Review Research, Issue 3, 2021, ISSN 2643-1564
Publisher: American Physical Society
DOI: 10.1103/physrevresearch.3.043097

Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro

Author(s): Julia Mester-Tonczar, Patrick Einzinger, Johannes Winkler, Nina Kastner, Andreas Spannbauer, Katrin Zlabinger, Denise Traxler, Dominika Lukovic, Ena Hasimbegovic, Georg Goliasch, Noemi Pavo, Mariann Gyöngyösi
Published in: International Journal of Molecular Sciences, Issue 22/3, 2021, Page(s) 1390, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031390

Pacemaker lead-associated tricuspid regurgitation in patients with or without pre-existing right ventricular dilatation

Author(s): Martin Riesenhuber, Andreas Spannbauer, Marianne Gwechenberger, Thomas Pezawas, Christoph Schukro, Günter Stix, Matthias Schneider, Georg Goliasch, Anahit Anvari, Thomas Wrba, Cesar Khazen, Martin Andreas, Günther Laufer, Christian Hengstenberg, Mariann Gyongyosi
Published in: Clinical Research in Cardiology, Issue 110/6, 2021, Page(s) 884-894, ISSN 1861-0684
Publisher: Steinkopff
DOI: 10.1007/s00392-021-01812-3

Reverse re-modelling chronic heart failure by reinstating heart rate variability

Author(s): J. Shanks, Y. Abukar, N. Lever, M. Pachen, I. LeGrice, D. J. Grossman, A. Nogaret, J. Paton
Published in: Basic Research in Cardiology, 2022, ISSN 1435-1803
Publisher: Springer
DOI: 10.1007/s00395-022-00911-0

Noise-activated barrier crossing in multiattractor dissipative neural networks

Author(s): Joseph D. Taylor, Ashok S. Chauhan, John T. Taylor, Andrey L. Shilnikov, and Alain Nogaret
Published in: Physical Review E covering statistical, nonlinear, biological, and soft matter physics, Issue 105, 2022, ISSN 1539-3755
Publisher: American Physical Society
DOI: 10.1103/physreve.105.064203

Approaches to Parameter Estimation from Model Neurons and Biological Neurons

Author(s): Alain Nogaret
Published in: Algorithms, 2022, ISSN 1999-4893
Publisher: MDPI Open Access Publishing
DOI: 10.3390/a15050168

Inhibition delay increases neural network capacity through Stirling transform

Author(s): Alain Nogaret, Alastair King
Published in: Physical Review E, Issue 97/3, 2018, ISSN 2470-0045
Publisher: American Society of Physics
DOI: 10.1103/PhysRevE.97.030301

Optimal solid state neurons

Author(s): Kamal Abu-Hassan, Joseph D. Taylor, Paul G. Morris, Elisa Donati, Zuner A. Bortolotto, Giacomo Indiveri, Julian F. R. Paton, Alain Nogaret
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13177-3

Enhancing respiratory sinus arrhythmia increases cardiac output in rats with left ventricular dysfunction

Author(s): Erin L. O'Callaghan, Renata M. Lataro, Eva L. Roloff, Ashok S. Chauhan, Helio C. Salgado, Edward Duncan, Alain Nogaret, Julian F. R. Paton
Published in: The Journal of Physiology, 2019, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp277293

Effect of Ischemic Preconditioning and Postconditioning on Exosome-Rich Fraction microRNA Levels, in Relation with Electrophysiological Parameters and Ventricular Arrhythmia in Experimental Closed-Chest Reperfused Myocardial Infarction

Author(s): Andreas Spannbauer, Denise Traxler, Dominika Lukovic, Katrin Zlabinger, Johannes Winkler, Alfred Gugerell, Péter Ferdinandy, Derek J. Hausenloy, Noemi Pavo, Maximilian Y. Emmert, Simon P. Hoerstrup, Andras Jakab, Mariann Gyöngyösi, Martin Riesenhuber
Published in: International Journal of Molecular Sciences, Issue 20/9, 2019, Page(s) 2140, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20092140

Robust neuromorphic coupled oscillators for adaptive pacemakers

Author(s): Renate Krause, Joanne J. A. van Bavel, Chenxi Wu, Marc A. Vos, Alain Nogaret, Giacomo Indiveri
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-97314-3

Resilience of Neural Electronics to High Magnetic Fields

Author(s): Jonathan Graham Harper Carter, Alain Nogaret, Hugh Blakes, Ben Metcalfe, John Taylor
Published in: Journal of Electronic Materials, 2022, ISSN 0361-5235
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1007/s11664-022-09719-z

Sex Differences and Long-Term Outcome in Patients With Pacemakers

Author(s): Martin Riesenhuber, Andreas Spannbauer, Friedrich Rauscha, Herwig Schmidinger, Adelinde Boszotta, Thomas Pezawas, Christoph Schukro, Marianne Gwechenberger, Günter Stix, Anahit Anvari, Thomas Wrba, Cesar Khazen, Martin Andreas, Günther Laufer, Christian Hengstenberg, Mariann Gyöngyösi
Published in: Frontiers in Cardiovascular Medicine, Issue 7, 2020, ISSN 2297-055X
Publisher: Frontiersin.org
DOI: 10.3389/fcvm.2020.569060

Conference proceedings (1)

Deriving optimal silicon neuron circuit specifications using Data Assimilation

Author(s): Elisa Donati, Kamal Abu Hassan, Alain Nogaret, Giacomo Indiveri
Published in: 2018 IEEE International Symposium on Circuits and Systems (ISCAS), 2018, Page(s) 1-5, ISBN 978-1-5386-4881-0
Publisher: IEEE
DOI: 10.1109/ISCAS.2018.8351338