Deliverables Documents, reports (10) Report of final meeting and list of publications Report of final meeting and list of publications Establish and qualify SMFA using the transgenic parasite Establish and qualify SMFA using the transgenic parasite PfPvs25 Report on the analysis of CHMI serological immuno-profiling Report on the analysis of CHMI serological immunoprofiling Report on the safety, immunogenicity and efficacy of ChAd-MVA PvDBP_RII against blood-stage parasite challenge in a Phase I/IIa efficacy trial VAC071A/B Report on the safety immunogenicity and efficacy of ChAdMVA PvDBPRII against bloodstage parasite challenge in a Phase IIIa efficacy trial VAC071AB Assessment of GIA of new candidate antigens using novel transgenic P. knowlesi parasites Assessment of GIA of new candidate antigens using novel transgenic P knowlesi parasites Report on the safety, immunogenicity and immuno-efficacy of Pvs25-IMX313 in Matrix-M1 adjuvant Report on the safety immunogenicity and immunoefficacy of Pvs25IMX313 in MatrixM1 adjuvant for transmissionblocking vaccine clinical trial Establish transgenic P. knowlesi GIA assay methodology and assess blood-stage clinical trial samples Establish transgenic P. knowlesi GIA assay methodology and assess blood-stage clinical trial samples Generation and fitness assessment of transgenic parasite Pf-Pvs25 Generation and fitness assessment of transgenic parasite Pf-Pvs25 to develop SMFA assay Report on the analysis of RNAseq datasets Report on the analysis of RNAseq datasets Report on the safety, efficacy and transmissibility of homologous secondary and tertiary re-infection in all three groups with blood-stage P. vivax in a CHMI model (VAC069A-F). Report on the safety efficacy and transmissibility of homologous secondary and tertiary reinfection in all three groups with bloodstage P vivax in a CHMI model VAC069AF Websites, patent fillings, videos etc. (1) Description of website Description of website Publications Peer reviewed articles (4) Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody Author(s): Thomas. A. Rawlinson, Natalie M. Barber, Franziska Mohring, Jee Sun Cho, Varakorn Kosaisavee, Samuel F. Gérard, Daniel G. W. Alanine, Geneviève M. Labbé, Sean C. Elias, Sarah E. Silk, Doris Quinkert, Jing Jin, Jennifer M. Marshall, Ruth O. Payne, Angela M. Minassian, Bruce Russell, Laurent Rénia, François H. Nosten, Robert W. Moon, Matthew K. Higgins, Simon J. Draper Published in: Nature Microbiology, Issue 4/9, 2019, Page(s) 1497-1507, ISSN 2058-5276 Publisher: Nature Research DOI: 10.1038/s41564-019-0462-1 Multiplication and Growth Inhibition Activity Assays for the Zoonotic Malaria Parasite, Plasmodium knowlesi Author(s): Franziska Mohring1, Thomas A. Rawlinson2, Simon J. Draper2 and Robert W. Moon Published in: National Library of Medicine, 2020, ISSN 2331-8325 Publisher: Bio-protocol DOI: 10.21769/bioprotoc.3743 Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection Author(s): Mimi M. Hou1,2,3, Jordan R. Barrett1,2,3, Yrene Themistocleous2, Thomas A. Rawlinson2, Ababacar Diouf4, Francisco J. Martinez5, Carolyn M. Nielsen1,2,3, Amelia M. Lias1,2,3, Lloyd D. W. King1,2,3, Nick J. Edwards2, Nicola M. Greenwood2, Lucy Kingham2, Ian D. Poulton2, Baktash Khozoee2, Cyndi Goh2, Susanne H. Hodgson1,2,3, Dylan J. Mac Lochlainn1,2,3, Jo Salkeld1,2,3, Micheline Guillotte-Blisni Published in: National Library of Medicine, 2023, ISSN 1946-6234 Publisher: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.adf1782 Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly Author(s): Angela M. Minassian, Yrene Themistocleous, Sarah E. Silk, Jordan R. Barrett, Alison Kemp, Doris Quinkert, Carolyn M. Nielsen, Nick J. Edwards, Thomas A. Rawlinson, Fernando Ramos Lopez, Wanlapa Roobsoong, Katherine J.D. Ellis, Jee-Sun Cho, Eerik Aunin, Thomas D. Otto, Adam J. Reid, Florian A. Bach, Geneviève M.C. Labbé, Ian D. Poulton, Arianna Marini, Marija Zaric, Margaux Mulatier, Raquel Lopez Published in: National Library of Medicine, 2021, ISSN 2379-3708 Publisher: JCI insight DOI: 10.1172/jci.insight.152465 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
