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Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria

Deliverables

Report of final meeting and list of publications
Establish and qualify SMFA using the transgenic parasite

Establish and qualify SMFA using the transgenic parasite PfPvs25

Report on the analysis of CHMI serological immuno-profiling

Report on the analysis of CHMI serological immunoprofiling

Report on the safety, immunogenicity and efficacy of ChAd-MVA PvDBP_RII against blood-stage parasite challenge in a Phase I/IIa efficacy trial VAC071A/B

Report on the safety immunogenicity and efficacy of ChAdMVA PvDBPRII against bloodstage parasite challenge in a Phase IIIa efficacy trial VAC071AB

Assessment of GIA of new candidate antigens using novel transgenic P. knowlesi parasites

Assessment of GIA of new candidate antigens using novel transgenic P knowlesi parasites

Report on the safety, immunogenicity and immuno-efficacy of Pvs25-IMX313 in Matrix-M1 adjuvant

Report on the safety immunogenicity and immunoefficacy of Pvs25IMX313 in MatrixM1 adjuvant for transmissionblocking vaccine clinical trial

Establish transgenic P. knowlesi GIA assay methodology and assess blood-stage clinical trial samples
Generation and fitness assessment of transgenic parasite Pf-Pvs25

Generation and fitness assessment of transgenic parasite Pf-Pvs25 to develop SMFA assay

Report on the analysis of RNAseq datasets
Report on the safety, efficacy and transmissibility of homologous secondary and tertiary re-infection in all three groups with blood-stage P. vivax in a CHMI model (VAC069A-F).

Report on the safety efficacy and transmissibility of homologous secondary and tertiary reinfection in all three groups with bloodstage P vivax in a CHMI model VAC069AF

Publications

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody

Author(s): Thomas. A. Rawlinson, Natalie M. Barber, Franziska Mohring, Jee Sun Cho, Varakorn Kosaisavee, Samuel F. Gérard, Daniel G. W. Alanine, Geneviève M. Labbé, Sean C. Elias, Sarah E. Silk, Doris Quinkert, Jing Jin, Jennifer M. Marshall, Ruth O. Payne, Angela M. Minassian, Bruce Russell, Laurent Rénia, François H. Nosten, Robert W. Moon, Matthew K. Higgins, Simon J. Draper
Published in: Nature Microbiology, Issue 4/9, 2019, Page(s) 1497-1507, ISSN 2058-5276
Publisher: Nature Research
DOI: 10.1038/s41564-019-0462-1

Multiplication and Growth Inhibition Activity Assays for the Zoonotic Malaria Parasite, Plasmodium knowlesi

Author(s): Franziska Mohring1, Thomas A. Rawlinson2, Simon J. Draper2 and Robert W. Moon
Published in: National Library of Medicine, 2020, ISSN 2331-8325
Publisher: Bio-protocol
DOI: 10.21769/bioprotoc.3743

Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection

Author(s): Mimi M. Hou1,2,3, Jordan R. Barrett1,2,3, Yrene Themistocleous2, Thomas A. Rawlinson2, Ababacar Diouf4, Francisco J. Martinez5, Carolyn M. Nielsen1,2,3, Amelia M. Lias1,2,3, Lloyd D. W. King1,2,3, Nick J. Edwards2, Nicola M. Greenwood2, Lucy Kingham2, Ian D. Poulton2, Baktash Khozoee2, Cyndi Goh2, Susanne H. Hodgson1,2,3, Dylan J. Mac Lochlainn1,2,3, Jo Salkeld1,2,3, Micheline Guillotte-Blisni
Published in: National Library of Medicine, 2023, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adf1782

Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

Author(s): Angela M. Minassian, Yrene Themistocleous, Sarah E. Silk, Jordan R. Barrett, Alison Kemp, Doris Quinkert, Carolyn M. Nielsen, Nick J. Edwards, Thomas A. Rawlinson, Fernando Ramos Lopez, Wanlapa Roobsoong, Katherine J.D. Ellis, Jee-Sun Cho, Eerik Aunin, Thomas D. Otto, Adam J. Reid, Florian A. Bach, Geneviève M.C. Labbé, Ian D. Poulton, Arianna Marini, Marija Zaric, Margaux Mulatier, Raquel Lopez
Published in: National Library of Medicine, 2021, ISSN 2379-3708
Publisher: JCI insight
DOI: 10.1172/jci.insight.152465

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