Deliverables
Establish and qualify SMFA using the transgenic parasite
Establish and qualify SMFA using the transgenic parasite PfPvs25
Report on the analysis of CHMI serological immuno-profilingReport on the analysis of CHMI serological immunoprofiling
Report on the safety, immunogenicity and efficacy of ChAd-MVA PvDBP_RII against blood-stage parasite challenge in a Phase I/IIa efficacy trial VAC071A/BReport on the safety immunogenicity and efficacy of ChAdMVA PvDBPRII against bloodstage parasite challenge in a Phase IIIa efficacy trial VAC071AB
Assessment of GIA of new candidate antigens using novel transgenic P. knowlesi parasitesAssessment of GIA of new candidate antigens using novel transgenic P knowlesi parasites
Report on the safety, immunogenicity and immuno-efficacy of Pvs25-IMX313 in Matrix-M1 adjuvantReport on the safety immunogenicity and immunoefficacy of Pvs25IMX313 in MatrixM1 adjuvant for transmissionblocking vaccine clinical trial
Establish transgenic P. knowlesi GIA assay methodology and assess blood-stage clinical trial samplesGeneration and fitness assessment of transgenic parasite Pf-Pvs25
Generation and fitness assessment of transgenic parasite Pf-Pvs25 to develop SMFA assay
Report on the analysis of RNAseq datasetsReport on the safety, efficacy and transmissibility of homologous secondary and tertiary re-infection in all three groups with blood-stage P. vivax in a CHMI model (VAC069A-F).
Report on the safety efficacy and transmissibility of homologous secondary and tertiary reinfection in all three groups with bloodstage P vivax in a CHMI model VAC069AF
Publications
Author(s):
Thomas. A. Rawlinson, Natalie M. Barber, Franziska Mohring, Jee Sun Cho, Varakorn Kosaisavee, Samuel F. Gérard, Daniel G. W. Alanine, Geneviève M. Labbé, Sean C. Elias, Sarah E. Silk, Doris Quinkert, Jing Jin, Jennifer M. Marshall, Ruth O. Payne, Angela M. Minassian, Bruce Russell, Laurent Rénia, François H. Nosten, Robert W. Moon, Matthew K. Higgins, Simon J. Draper
Published in:
Nature Microbiology, Issue 4/9, 2019, Page(s) 1497-1507, ISSN 2058-5276
Publisher:
Nature Research
DOI:
10.1038/s41564-019-0462-1
Author(s):
Franziska Mohring1, Thomas A. Rawlinson2, Simon J. Draper2 and Robert W. Moon
Published in:
National Library of Medicine, 2020, ISSN 2331-8325
Publisher:
Bio-protocol
DOI:
10.21769/bioprotoc.3743
Author(s):
Mimi M. Hou1,2,3, Jordan R. Barrett1,2,3, Yrene Themistocleous2, Thomas A. Rawlinson2,
Ababacar Diouf4, Francisco J. Martinez5, Carolyn M. Nielsen1,2,3, Amelia M. Lias1,2,3, Lloyd
D. W. King1,2,3, Nick J. Edwards2, Nicola M. Greenwood2, Lucy Kingham2, Ian D. Poulton2,
Baktash Khozoee2, Cyndi Goh2, Susanne H. Hodgson1,2,3, Dylan J. Mac Lochlainn1,2,3,
Jo Salkeld1,2,3, Micheline Guillotte-Blisni
Published in:
National Library of Medicine, 2023, ISSN 1946-6234
Publisher:
American Association for the Advancement of Science
DOI:
10.1126/scitranslmed.adf1782
Author(s):
Angela M. Minassian, Yrene Themistocleous, Sarah E. Silk, Jordan R. Barrett, Alison Kemp, Doris Quinkert, Carolyn M. Nielsen, Nick J. Edwards, Thomas A. Rawlinson, Fernando Ramos Lopez, Wanlapa Roobsoong, Katherine J.D. Ellis, Jee-Sun Cho, Eerik Aunin, Thomas D. Otto, Adam J. Reid, Florian A. Bach, Geneviève M.C. Labbé, Ian D. Poulton, Arianna Marini, Marija Zaric, Margaux Mulatier, Raquel Lopez
Published in:
National Library of Medicine, 2021, ISSN 2379-3708
Publisher:
JCI insight
DOI:
10.1172/jci.insight.152465
Searching for OpenAIRE data...
There was an error trying to search data from OpenAIRE
No results available