Project description
Uniting global forces against the Zika virus
The Zika virus (ZIKV) is a mosquito-borne virus that raised global concern following a major outbreak in 2015. One of the most concerning aspects of ZIKV is its association with birth defects, particularly small head and brain in infants born to mothers infected during pregnancy. The scope of the EU-funded ZIKAlliance initiative is to understand the impact of ZIKV infection during pregnancy and study the natural history of ZIKV infection in humans. The consortium will undertake a multidisciplinary approach to study cohorts in the Caribbean, Central and South America in countries with different epidemiological profiles. The long-term aim is to build research capacity and enhance preparedness for future epidemic threats.
Objective
"ZIKAlliance is a multidisciplinary project with a global ""One Health"" approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status."
Fields of science
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health sciencesbasic medicinephysiologypathophysiology
- medical and health sciencesclinical medicineobstetrics
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
75654 Paris
France
See on map
Participants (56)
69120 Heidelberg
See on map
21040 900 Rio De Janeiro
See on map
3015 GD Rotterdam
See on map
2333 ZA Leiden
See on map
3000 Leuven
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
3001 Heverlee
See on map
53127 Bonn
See on map
75724 Paris
See on map
OX1 2JD Oxford
See on map
75015 PARIS
See on map
13572 Marseille
See on map
40110 160 Salvador
See on map
75015 PARIS 15
See on map
75794 Paris
See on map
WC1E 7HT London
See on map
1099 085 Lisboa
See on map
13284 Marseille
See on map
0456 Oslo
See on map
53100 Siena
See on map
62100 Cuernavaca Morelos
See on map
06600 Mexico City
See on map
1066 CX Amsterdam
See on map
9713 GZ Groningen
See on map
Bucaramanga
See on map
Participation ended
80539 Munchen
See on map
4000 Liege
See on map
31270 901 Belo Horizonte Minas Gerais
See on map
98713 Papeete
See on map
3003 Bern
See on map
08007 Barcelona
See on map
30559 Hannover
See on map
69117 Heidelberg
See on map
2340 Beerse
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
92787 Issy Les Moulineaux
See on map
94700 Maisons Alfort
See on map
090510 Guayaquil
See on map
08140 Caldes De Montbui Barcelona
See on map
8006 Zurich
See on map
G12 8QQ Glasgow
See on map
20359 Hamburg
See on map
11300 La Habana
See on map
38098 San Michele All'Adige
See on map
69622 Villeurbanne Cedex
See on map
35043 Rennes Cedex
See on map
74001 970 Goiania
See on map
6708 PB Wageningen
See on map
6500 Bellinzona
See on map
000 Phnom Penh
See on map
DAKAR Dakar
See on map
98845 Noumea
See on map
200025 SHANGHAI
See on map
05401 000 Sao Paulo
See on map
25651-075 Petropolis
See on map
39106 Magdeburg
See on map
10117 Berlin
See on map
31 LIMA
See on map