Objetivo
The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases. By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities. Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives.
IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs. Research carried out by INSPIRED partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.
Ámbito científico
- ciencias médicas y de la saludmedicina clínicacáncercáncer de mama
- ciencias socialeseconomía y empresagestión y empresasempleo
- ciencias médicas y de la saludmedicina básicaneurologíaesclerosis lateral amiotrófica
- ciencias naturalesciencias biológicasbioquímicabiomoléculasproteínas
- ciencias médicas y de la saludmedicina básicaneurologíaalzheimer
Programa(s)
Convocatoria de propuestas
H2020-MSCA-RISE-2016
Consulte otros proyectos de esta convocatoria
Régimen de financiación
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
Coordinador
H91 Galway
Irlanda
Participantes (5)
75654 Paris
17671 Kallithea
14476 Potsdam
405 30 Goeteborg
Galway
Socios (3)
10 Santiago
La participación finalizó
91355 Valencia
91320 Newbury Park