Deliverables Websites, patent fillings, videos etc. (2) Consortium web site established Consortium web site established Creation of Facebook & Twitter accounts Creation of Facebook & Twitter accounts Publications Peer reviewed articles (35) Tumour Cell Secretome in Chemoresistance and Tumour Recurrence Author(s): Emma C. Madden, Adrienne M. Gorman, Susan E. Logue, Afshin Samali Published in: Trends in Cancer, Issue 6/6, 2020, Page(s) 489-505, ISSN 2405-8033 Publisher: Cell Press DOI: 10.1016/j.trecan.2020.02.020 Pharmacological Targeting of IRE1 in Cancer Author(s): Diana Pelizzari Raymundo, Dimitrios Doultsinos, Xavier Guillory, Antonio Carlesso, Leif A. Eriksson, Eric Chevet Published in: Trends in Cancer, Issue 6/12, 2020, Page(s) 1018-1030, ISSN 2405-8033 Publisher: Cell Press DOI: 10.1016/j.trecan.2020.07.006 The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors Author(s): Mohamed Mahameed, Thomas Wilhelm, Odai Darawshi, Akram Obiedat, Weiss-Sadan Tommy, Chetan Chintha, Thomas Schubert, Afshin Samali, Eric Chevet, Leif A. Eriksson, Michael Huber, Boaz Tirosh Published in: Cell Death & Disease, Issue 10/4, 2019, ISSN 2041-4889 Publisher: Nature Publishing Group DOI: 10.1038/s41419-019-1523-3 Regulation of lipid metabolism by the unfolded protein response Author(s): Matthieu Moncan, Katarzyna Mnich, Arnaud Blomme, Aitor Almanza, Afshin Samali, Adrienne M. Gorman Published in: Journal of Cellular and Molecular Medicine, Issue 25/3, 2021, Page(s) 1359-1370, ISSN 1582-1838 Publisher: Wiley-Blackwell DOI: 10.1111/jcmm.16255 New insights on human IRE1 tetramer structures based on molecular modeling Author(s): Antonio Carlesso, Johanna Hörberg, Anna Reymer, Leif A. Eriksson Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-74347-8 When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response Author(s): Matías González-Quiroz, Alice Blondel, Alfredo Sagredo, Claudio Hetz, Eric Chevet, Rémy Pedeux Published in: Trends in Cell Biology, Issue 30/11, 2020, Page(s) 881-891, ISSN 0962-8924 Publisher: Elsevier BV DOI: 10.1016/j.tcb.2020.09.002 Deciphering the selectivity of inhibitor MKC9989 towards residue K907 in IRE1α; a multiscale in silico approach Author(s): Sayyed Jalil Mahdizadeh, Antonio Carlesso, Leif A. Eriksson Published in: RSC Advances, Issue 10/33, 2020, Page(s) 19720-19729, ISSN 2046-2069 Publisher: Royal Society of Chemistry DOI: 10.1039/d0ra01895c Reconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein–Protein Docking Meta-Approach Author(s): Sayyed Jalil Mahdizadeh, Melissa Thomas, Leif A. Eriksson Published in: Journal of Chemical Information and Modeling, Issue 61/7, 2021, Page(s) 3543-3558, ISSN 1549-9596 Publisher: American Chemical Society DOI: 10.1021/acs.jcim.1c00301 Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease Author(s): Cynthia Lebeaupin, Deborah Vallée, Younis Hazari, Claudio Hetz, Eric Chevet, Béatrice Bailly-Maitre Published in: Journal of Hepatology, Issue 69/4, 2018, Page(s) 927-947, ISSN 0168-8278 Publisher: Elsevier BV DOI: 10.1016/j.jhep.2018.06.008 Control of anterior GR adient 2 ( AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation Author(s): Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif Published in: EMBO Molecular Medicine, Issue 11/6, 2019, ISSN 1757-4676 Publisher: John Wiley & Sons Ltd. DOI: 10.15252/emmm.201810120 Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges Author(s): Daria Sicari, Aeid Igbaria, Eric Chevet Published in: Cells, Issue 8/11, 2019, Page(s) 1347, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells8111347 Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Author(s): Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E. Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L. Sassano, Philippe Pihán, Alexander R. van Vliet, Matías González-Quiroz, Angie K. Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J. Kaufman, Nibaldo C. Inestrosa, Christian Gonzalez-Billault, R. Luke Wiseman, Patr Published in: Nature Cell Biology, Issue 21/6, 2019, Page(s) 755-767, ISSN 1465-7392 Publisher: Nature Publishing Group DOI: 10.1038/s41556-019-0329-y Peptidomimetic‐based identification of FDA‐approved compounds inhibiting IRE1 activity Author(s): Dimitrios Doultsinos, Antonio Carlesso, Chetan Chintha, James C. Paton, Adrienne W. Paton, Afshin Samali, Eric Chevet, Leif A. Eriksson Published in: The FEBS Journal, Issue 288/3, 2021, Page(s) 945-960, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.15372 The UPRosome – decoding novel biological outputs of IRE1α function Author(s): Hery Urra, Philippe Pihán, Claudio Hetz Published in: Journal of Cell Science, Issue 133/15, 2020, ISSN 0021-9533 Publisher: The Company of Biologists Ltd. DOI: 10.1242/jcs.218107 The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability Author(s): Viviana Pérez, Francisca Bermedo-Garcia, Diego Zelada, Felipe A. Court, Miguel Ángel Pérez, Marco Fuenzalida, Johanna Ábrigo, Claudio Cabello-Verrugio, Guillermo Moya-Alvarado, Juan Carlos Tapia, Vicente Valenzuela, Claudio Hetz, Francisca C. Bronfman, Juan Pablo Henríquez Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.1186/s40478-019-0802-7 Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α Author(s): Denisse Sepulveda, Diego Rojas-Rivera, Diego A. Rodríguez, Jody Groenendyk, Andres Köhler, Cynthia Lebeaupin, Shinya Ito, Hery Urra, Amado Carreras-Sureda, Younis Hazari, Mireille Vasseur-Cognet, Maruf M.U. Ali, Eric Chevet, Gisela Campos, Patricio Godoy, Tomas Vaisar, Béatrice Bailly-Maitre, Kazuhiro Nagata, Marek Michalak, Jimena Sierralta, Claudio Hetz Published in: Molecular Cell, Issue 69/2, 2018, Page(s) 238-252.e7, ISSN 1097-2765 Publisher: Cell Press DOI: 10.1016/j.molcel.2017.12.028 Dual IRE1 RNase functions dictate glioblastoma development Author(s): Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B P Published in: EMBO Molecular Medicine, Issue 10/3, 2018, Page(s) e7929, ISSN 1757-4676 Publisher: John Wiley & Sons Ltd. DOI: 10.15252/emmm.201707929 Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy Author(s): Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-018-05763-8 Regulation of tumor-stroma interactions by the unfolded protein response Author(s): Joanna Obacz, Tony Avril, Camila Rubio-Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet Published in: The FEBS Journal, 2017, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.14359 The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics Author(s): Amado Carreras-Sureda, Philippe Pihán, Claudio Hetz Published in: Frontiers in Oncology, Issue 7, 2017, ISSN 2234-943X Publisher: Frontiers Media S. A. DOI: 10.3389/fonc.2017.00055 Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis Author(s): Danilo B. Medinas, Jose V. González, Paulina Falcon, Claudio Hetz Published in: Frontiers in Molecular Neuroscience, Issue 10, 2017, ISSN 1662-5099 Publisher: Frontiers Research Foundation DOI: 10.3389/fnmol.2017.00216 Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts Author(s): Gabriela Mercado, Claudio Hetz Published in: Brain, Issue 140/6, 2017, Page(s) 1544-1547, ISSN 0006-8950 Publisher: Oxford University Press DOI: 10.1093/brain/awx107 Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications Author(s): Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Re Published in: The FEBS Journal, Issue 286/2, 2019, Page(s) 241-278, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.14608 The Unfolded Protein Response and Cell Fate Control Author(s): Claudio Hetz, Feroz R. Papa Published in: Molecular Cell, Issue 69/2, 2018, Page(s) 169-181, ISSN 1097-2765 Publisher: Cell Press DOI: 10.1016/j.molcel.2017.06.017 BCL-2 family: integrating stress responses at the ER to control cell demise Author(s): Philippe Pihán, Amado Carreras-Sureda, Claudio Hetz Published in: Cell Death and Differentiation, Issue 24/9, 2017, Page(s) 1478-1487, ISSN 1350-9047 Publisher: Nature Publishing Group DOI: 10.1038/cdd.2017.82 Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model Author(s): Leslie Bargsted, Danilo B. Medinas, Francisca Martínez Traub, Pablo Rozas, Natalia Muñoz, Melissa Nassif, Carolina Jerez, Alejandra Catenaccio, Felipe A. Court, Claudio Hetz, Soledad Matus Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-017-14399-5 The Unfolded Protein Response in Breast Cancer Author(s): Eoghan McGrath, Susan Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne Gorman, Afshin Samali Published in: Cancers, Issue 10/10, 2018, Page(s) 344, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers10100344 IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A Author(s): Hery Urra, Daniel R. Henriquez, José Cánovas, David Villarroel-Campos, Amado Carreras-Sureda, Eduardo Pulgar, Emiliano Molina, Younis M. Hazari, Celia M. Limia, Sebastián Alvarez-Rojas, Ricardo Figueroa, Rene L. Vidal, Diego A. Rodriguez, Claudia A. Rivera, Felipe A. Court, Andrés Couve, Ling Qi, Eric Chevet, Ryoko Akai, Takao Iwawaki, Miguel L. Concha, Álvaro Glavic, Christian Gonzalez-Billa Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 942-953, ISSN 1465-7392 Publisher: Nature Publishing Group DOI: 10.1038/s41556-018-0141-0 A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems Author(s): Daria Sicari, Agnès Delaunay‐Moisan, Laurent Combettes, Eric Chevet, Aeid Igbaria Published in: The FEBS Journal, Issue 287/1, 2019, Page(s) 27-42, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.15107 The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease Author(s): Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A. Court Published in: Cell Death & Differentiation, Issue 27/4, 2020, Page(s) 1169-1185, ISSN 1350-9047 Publisher: Nature Publishing Group DOI: 10.1038/s41418-019-0408-4 Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1 Author(s): Chetan Chintha, Antonio Carlesso, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson Published in: RSC Advances, Issue 10/1, 2020, Page(s) 367-375, ISSN 2046-2069 Publisher: Royal Society of Chemistry DOI: 10.1039/c9ra08047c CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule Author(s): Chloé Sauzay, Konstantinos Voutetakis, Aristotelis Chatziioannou, Eric Chevet, Tony Avril Published in: Frontiers in Cell and Developmental Biology, Issue 7, 2019, ISSN 2296-634X Publisher: Frontiers DOI: 10.3389/fcell.2019.00066 Role of the early secretory pathway in SARS-CoV-2 infection Author(s): Daria Sicari, Aristotelis Chatziioannou, Theodoros Koutsandreas, Roberto Sitia, Eric Chevet Published in: Journal of Cell Biology, Issue 219/9, 2020, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.202006005 Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion Author(s): Celia Limia, Chloé Sauzay, Hery Urra, Claudio Hetz, Eric Chevet, Tony Avril Published in: Cancers, Issue 11/5, 2019, Page(s) 631, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers11050631 Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response Author(s): Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, Alfredo I. Sagredo, Denisse Sepulveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A. Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M. Domingos, Rémy Pedeux, Eric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walt Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-15694-y Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
