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Targeting IRE1 in disease

Deliverables

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Publications

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

Author(s): Denisse Sepulveda, Diego Rojas-Rivera, Diego A. Rodríguez, Jody Groenendyk, Andres Köhler, Cynthia Lebeaupin, Shinya Ito, Hery Urra, Amado Carreras-Sureda, Younis Hazari, Mireille Vasseur-Cognet, Maruf M.U. Ali, Eric Chevet, Gisela Campos, Patricio Godoy, Tomas Vaisar, Béatrice Bailly-Maitre, Kazuhiro Nagata, Marek Michalak, Jimena Sierralta, Claudio Hetz
Published in: Molecular Cell, Issue 69/2, 2018, Page(s) 238-252.e7, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.12.028

Dual IRE1 RNase functions dictate glioblastoma development


Published in: ISSN 1757-4676
DOI: 10.15252/emmm.201707929

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Author(s): Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-05763-8

Regulation of tumor-stroma interactions by the unfolded protein response

Author(s): Joanna Obacz, Tony Avril, Camila Rubio-Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet
Published in: The FEBS Journal, 2017, ISSN 1742-464X
DOI: 10.1111/febs.14359

The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics

Author(s): Amado Carreras-Sureda, Philippe Pihán, Claudio Hetz
Published in: Frontiers in Oncology, Issue 7, 2017, ISSN 2234-943X
DOI: 10.3389/fonc.2017.00055

Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis

Author(s): Danilo B. Medinas, Jose V. González, Paulina Falcon, Claudio Hetz
Published in: Frontiers in Molecular Neuroscience, Issue 10, 2017, ISSN 1662-5099
DOI: 10.3389/fnmol.2017.00216

Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts

Author(s): Gabriela Mercado, Claudio Hetz
Published in: Brain, Issue 140/6, 2017, Page(s) 1544-1547, ISSN 0006-8950
DOI: 10.1093/brain/awx107

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications

Author(s): Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Re
Published in: The FEBS Journal, Issue 286/2, 2019, Page(s) 241-278, ISSN 1742-464X
DOI: 10.1111/febs.14608

The Unfolded Protein Response and Cell Fate Control

Author(s): Claudio Hetz, Feroz R. Papa
Published in: Molecular Cell, Issue 69/2, 2018, Page(s) 169-181, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.06.017

BCL-2 family: integrating stress responses at the ER to control cell demise

Author(s): Philippe Pihán, Amado Carreras-Sureda, Claudio Hetz
Published in: Cell Death and Differentiation, Issue 24/9, 2017, Page(s) 1478-1487, ISSN 1350-9047
DOI: 10.1038/cdd.2017.82

Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model

Author(s): Leslie Bargsted, Danilo B. Medinas, Francisca Martínez Traub, Pablo Rozas, Natalia Muñoz, Melissa Nassif, Carolina Jerez, Alejandra Catenaccio, Felipe A. Court, Claudio Hetz, Soledad Matus
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-14399-5

The Unfolded Protein Response in Breast Cancer

Author(s): Eoghan McGrath, Susan Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne Gorman, Afshin Samali
Published in: Cancers, Issue 10/10, 2018, Page(s) 344, ISSN 2072-6694
DOI: 10.3390/cancers10100344

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A

Author(s): Hery Urra, Daniel R. Henriquez, José Cánovas, David Villarroel-Campos, Amado Carreras-Sureda, Eduardo Pulgar, Emiliano Molina, Younis M. Hazari, Celia M. Limia, Sebastián Alvarez-Rojas, Ricardo Figueroa, Rene L. Vidal, Diego A. Rodriguez, Claudia A. Rivera, Felipe A. Court, Andrés Couve, Ling Qi, Eric Chevet, Ryoko Akai, Takao Iwawaki, Miguel L. Concha, Álvaro Glavic, Christian Gonzalez-Billa
Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 942-953, ISSN 1465-7392
DOI: 10.1038/s41556-018-0141-0