Livrables Documents, reports (11) Protocols for exposure of liver slices to 2-3 selected cholestatic drugs Standard protocols for inducing cholestasis to be used by all project partners (drugs to be used, concentrations, exposure times, etc) Metabolomic signatures of healthy and cholestatic tissue slices by NMR and complementary techniques Metabolomic characterisation of the effects of druginduced cholestasis by NMR using the novel perfusionNMR devices and comparison to data from conventional techniques Feasibility of micro-NMR as stand-alone technique for acquisition of metabolomic signatures of liver tissue Demonstration of NMR metabolomic characterisation of PCLS Selection of protocols for tissue harvest and incubation Definition of best practice protocols for deployment to project partners in Southampton and Karlsruhe Report on project symposium 1 Overview of project symposium, list of presentations, and select presentation materials Final hypothesis for mechanism of liver damage by drug-induced cholestasis Publication of known facts and resulting hypothesis on the mechanism of liver damage by druginduced cholestasis Information on changes in composition of primary bile during cholestasis Characterisation of the ability of the new NMR tools to provide information on bile composition in PCLS and its changes upon cholestasis Report on viability and functionality of PCLS in novel NMR/perfusion systems Detailed report comparing viability and functionality of liver slices in the static NMRperfusion system and the LoD perfusion device Functional characterisation of cholestatic effects by conventional methods quantification of the signature effects of the selected cholestatic drugs on PCLS by nonNMR means such as mRNA expression assays HPLC bile acid assays Information on spatial distribution of cholestatic events in the liver acinus Characterisation of the ability of the novel NMR protocols to provide spatial information on the distribution of cholestatic damage in liver tissue Optimised TLP-NMR System publication describing transmission line probe/perfusion system, its basic operation, and performance parameters Websites, patent fillings, videos etc. (3) Project Identity Project logo designed, website online, and twitter account established Press releases Press releases on discoveries, activities, and progress to be fielded about every 4 months, or as opportunity arises Project website Project website up and running; to be updated continuously Publications Peer reviewed articles (31) Real‐Time NMR Monitoring of Spatially Segregated Enzymatic Reactions in Multilayered Hydrogel Assemblies** Auteurs: Nurdiana Nordin, Lorenzo Bordonali, Hossein Davoodi, Novindi Dwi Ratnawati, Gudrun Gygli, Jan G. Korvink, Vlad Badilita, Neil MacKinnon Publié dans: Angewandte Chemie International Edition, Issue 60/35, 2021, Page(s) 19176-19182, ISSN 1433-7851 Éditeur: John Wiley & Sons Ltd. DOI: 10.1002/anie.202103585 Topologically optimized magnetic lens for magnetic resonance applications Auteurs: Sagar Wadhwa, Mazin Jouda, Yongbo Deng, Omar Nassar, Dario Mager, Jan G. Korvink Publié dans: Magnetic Resonance, Issue 1/2, 2020, Page(s) 225-236, ISSN 2699-0016 Éditeur: Groupement AMPERE DOI: 10.5194/mr-1-225-2020 Glassy carbon microelectrodes minimize induced voltages, mechanical vibrations, and artifacts in magnetic resonance imaging Auteurs: Surabhi Nimbalkar, Erwin Fuhrer, Pedro Silva, Tri Nguyen, Martin Sereno, Sam Kassegne, Jan Korvink Publié dans: Microsystems & Nanoengineering, Issue 5/1, 2019, Page(s) Article 61 pp.1-11, ISSN 2055-7434 Éditeur: Springer Nature with the Areospace Information Research Institute, Chinese Academy of Sciences DOI: 10.1038/s41378-019-0106-x Time-resolved non-invasive metabolomic monitoring of a single cancer spheroid by microfluidic NMR Auteurs: Bishnubrata Patra, Manvendra Sharma, William Hale, Marcel Utz Publié dans: Scientific Reports, Issue 11/1, 2021, Page(s) pp.1-11, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-020-79693-1 Direct Production of A Hyperpolarized Metabolite on a Microfluidic Chip Auteurs: Sylwia J Barker, Laurynas Dagys, William Hale, Barbara Ripka, James Eills, Manvendra Sharma, Malcolm H Levitt, Marcel Utz Publié dans: Analytical Chemistry, 2022, Page(s) in press, ISSN 1520-6882 Éditeur: American Chemical Society An NMR-compatible microfluidic platform enabling in situ electrochemistry. Auteurs: Hossein Davoodi; Nurdiana Nordin; Lorenzo Bordonali; Jan G. Korvink; Neil MacKinnon; Vlad Badilita Publié dans: Lab on a Chip, Issue 2020/17, 2020, Page(s) pp.3202-3212, ISSN 1473-0197 Éditeur: Royal Society of Chemistry DOI: 10.1039/d0lc00364f Polyaramid-Based Flexible Antibacterial Coatings Fabricated Using Laser-Induced Carbonization and Copper Electroplating Auteurs: Emil R Mamleyev, Fabian Falk, Peter G Weidler, Stefan Heissler, Sagar Wadhwa, Omar Nassar, CN Shyam Kumar, Christian Kübel, Christof Wöll, Monsur Islam, Dario Mager, Jan G Korvink Publié dans: ACS Applied Materials & Interfaces, Issue 2021, 2021, Page(s) 53193-53205, ISSN 1944-8252 Éditeur: ACS DOI: 10.1021/acsami.0c13058 Kinetic Investigation of a Cucurbit[7]uril-Based Pseudo[6]rotaxane System by Microfluidic NMR Auteurs: Yibin Sun, Hongxun Fang, Xujing Lin, Xiuxiu Wang, Ganyu Chen, Xinchang Wang, Zhongqun Tian, Liulin Yang, Marcel Utz, Xiaoyu Cao Publié dans: CCS Chemistry, 2021, Page(s) 1-26, ISSN 2096-5745 Éditeur: Chinese Chemical Society Publishing DOI: 10.31635/ccschem.021.202100773 Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy Auteurs: Marek Plata, William Hale, Manvendra Sharma, Jörn M. Werner, Marcel Utz Publié dans: Lab on a Chip, 2021, ISSN 1473-0197 Éditeur: Royal Society of Chemistry DOI: 10.1039/d0lc01100b Synergies between Hyperpolarized NMR and Microfluidics: A Review Auteurs: Eills, J, Hale, W., Utz, M. Publié dans: Progress in Nuclear Magnetic Resonance Spectroscopy, 2021, ISSN 0079-6565 Éditeur: Elsevier BV DOI: 10.1016/j.pnmrs.2021.09.001 Wirelessly powered and remotely controlled valve-array for highly multiplexed analytical assay automation on a centrifugal microfluidic platform Auteurs: Saraí M. Torres Delgado, David J. Kinahan, Lourdes Albina Nirupa Julius, Adam Mallette, David Sáenz Ardila, Rohit Mishra, Celina M. Miyazaki, Jan G. Korvink, Jens Ducrée, Dario Mager Publié dans: Biosensors and Bioelectronics, Issue 109, 2018, Page(s) 214-223, ISSN 0956-5663 Éditeur: Pergamon Press Ltd. DOI: 10.1016/j.bios.2018.03.012 High-Resolution Nuclear Magnetic Resonance Spectroscopy with Picomole Sensitivity by Hyperpolarization on a Chip Auteurs: Eills, James; Hale, William; Sharma, Manvendra; Rossetto, Matheus; Levitt, Malcolm H.; Utz, Marcel Publié dans: Journal of American Chemical Society, Issue 1, 2019, ISSN 0002-7863 Éditeur: American Chemical Society DOI: 10.1021/jacs.9b03507 Topology optimization on two-dimensional manifolds Auteurs: Yongbo Deng; Zhenyu Liu; Jan G. Korvink Publié dans: Computer methods in applied mechanics and engineering, Issue 1, 2020, ISSN 0045-7825 Éditeur: Elsevier BV DOI: 10.1016/j.cma.2020.112937 Leveraging 3D printing to enhance mass spectrometry: A review Auteurs: Maciej Grajewski, Matthias Hermann, Richard D. Oleschuk, Elisabeth Verpoorte, Gert IJ. Salentijn Publié dans: Analytica Chimica Acta, 2021, Page(s) 1-17, ISSN 0003-2670 Éditeur: Elsevier BV DOI: 10.1016/j.aca.2021.338332 Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy Auteurs: Hongxun Fang, Yibin Sun, Xinchang Wang, Manvendra Sharma, Zhong Chen, Xiaoyu Cao, Marcel Utz, Zhongqun Tian Publié dans: Science China Chemistry, Issue 61/11, 2018, Page(s) 1460-1464, ISSN 1674-7291 Éditeur: Zhongguo Kexue Zazhishe/Science in China Press DOI: 10.1007/s11426-018-9293-3 High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets Auteurs: William Hale, Gabriel Rossetto, Rachael Greenhalgh, Graeme Finch, Marcel Utz Publié dans: Lab on a Chip, Issue 18/19, 2018, Page(s) 3018-3024, ISSN 1473-0197 Éditeur: Royal Society of Chemistry DOI: 10.1039/c8lc00712h The eLoaD platform endows centrifugal microfluidics with on-disc power and communication Auteurs: Saraí M. Torres Delgado, Jan G. Korvink, Dario Mager Publié dans: Biosensors and Bioelectronics, Issue 117, 2018, Page(s) 464-473, ISSN 0956-5663 Éditeur: Pergamon Press Ltd. DOI: 10.1016/j.bios.2018.05.056 Modular transmission line probes for microfluidic nuclear magnetic resonance spectroscopy and imaging Auteurs: Manvendra Sharma, Marcel Utz Publié dans: Journal of Magnetic Resonance, Issue 303, 2019, Page(s) 75-81, ISSN 1090-7807 Éditeur: Academic Press DOI: 10.1016/j.jmr.2019.04.007 A multi-purpose, rolled-up, double-helix resonator Auteurs: Pedro F. Silva, Saraí M. Torres Delgado, Mazin Jouda, Dario Mager, Jan G. Korvink Publié dans: Journal of Magnetic Resonance, Issue 309, 2019, Page(s) 106599, ISSN 1090-7807 Éditeur: Academic Press DOI: 10.1016/j.jmr.2019.106599 Automatic Adaptive Gain for Magnetic Resonance Sensitivity Enhancement Auteurs: Mazin Jouda, Erwin Fuhrer, Pedro Silva, Jan G. Korvink, Neil MacKinnon Publié dans: Analytical Chemistry, Issue 91/3, 2019, Page(s) 2376-2383, ISSN 0003-2700 Éditeur: American Chemical Society DOI: 10.1021/acs.analchem.8b05148 “Small is beautiful” in NMR Auteurs: Jan G. Korvink, Neil MacKinnon, Vlad Badilita, Mazin Jouda Publié dans: Journal of Magnetic Resonance, Issue 306, 2019, Page(s) 112-117, ISSN 1090-7807 Éditeur: Academic Press DOI: 10.1016/j.jmr.2019.07.012 Broadband and multi-resonant sensors for NMR Auteurs: Hossein Davoodi, Mazin Jouda, Jan G. Korvink, Neil MacKinnon, Vlad Badilita Publié dans: Progress in Nuclear Magnetic Resonance Spectroscopy, Issue 112-113, 2019, Page(s) 34-54, ISSN 0079-6565 Éditeur: Elsevier BV DOI: 10.1016/j.pnmrs.2019.05.001 Gradient-induced mechanical vibration of neural interfaces during MRI Auteurs: Erwin Fuhrer, Mazin Jouda, Christopher O. Klein, Manfred Wilhelm, Jan G. Korvink Publié dans: IEEE Transactions on Biomedical Engineering, 2019, Page(s) 1-1, ISSN 0018-9294 Éditeur: Institute of Electrical and Electronics Engineers DOI: 10.1109/tbme.2019.2923693 Parahydrogen based NMR hyperpolarisation goes micro: an alveolus for small molecule chemosensing Auteurs: Lorenzo Bordonali, Nurdiana Nordin, Erwin Fuhrer, Neil MacKinnon, Jan G. Korvink Publié dans: Lab on a Chip, Issue 19/3, 2019, Page(s) 503-512, ISSN 1473-0197 Éditeur: Royal Society of Chemistry DOI: 10.1039/c8lc01259h Micro-textures inversely designed with overlayed-lithography manufacturability for wetting behavior in Cassie–Baxter status Auteurs: Yongbo Deng, Zhenyu Liu, Yasi Wang, Huigao Duan, Jan G. Korvink Publié dans: Applied Mathematical Modelling, Issue 74, 2019, Page(s) 621-640, ISSN 0307-904X Éditeur: Elsevier BV DOI: 10.1016/j.apm.2019.04.059 Selective excitation enables encoding and measurement of multiple diffusion parameters in a single experiment Auteurs: Neil MacKinnon, Mehrdad Alinaghian, Pedro Silva, Thomas Gloge, Burkhard Luy, Mazin Jouda, Jan G Korvink Publié dans: Magnetic Resonance, Issue 2021, 2021, Page(s) 835-842, ISSN 2699-0016 Éditeur: Copernicus DOI: 10.5194/mr-2-835-2021 ArduiTaM: accurate and inexpensive NMR auto tune and match system Auteurs: Mazin Jouda, Saraí M. Torres Delgado, Mehrdad Alinaghian Jouzdani, Dario Mager, Jan G. Korvink Publié dans: Magnetic Resonance, Issue 1/1, 2020, Page(s) 105-113, ISSN 2699-0016 Éditeur: Groupement AMPERE DOI: 10.5194/mr-1-105-2020 Microfluidic Overhauser DNP chip for signal-enhanced compact NMR Auteurs: Sebastian Z. Kiss, Neil MacKinnon, Jan G. Korvink Publié dans: Scientific Reports, Issue 11/1, 2021, Page(s) pp.1-11, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-021-83625-y Integrated impedance sensing of liquid sample plug flow enables automated high throughput NMR spectroscopy Auteurs: Omar Nassar, Mazin Jouda, Michael Rapp, Dario Mager, Jan G. Korvink, Neil MacKinnon Publié dans: Microsystems & Nanoengineering, Issue 7/1, 2021, Page(s) pp.1-17, ISSN 2055-7434 Éditeur: Nature Portfolio DOI: 10.1038/s41378-021-00253-2 Nanoantennas Inversely Designed to Couple Free Space and a Metal–Insulator–Metal Waveguide Auteurs: Yeming Han, Yu Lin, Wei Ma, Jan G Korvink, Huigao Duan, Yongbo Deng Publié dans: Nanomaterials, Issue 2021, 2021, Page(s) 3219, ISSN 2079-4991 Éditeur: MDPI DOI: 10.3390/nano11123219 Fiber bundle topology optimization of hierarchical microtextures for wetting behavior in Cassie-Baxter mode Auteurs: Yongbo Deng, Weihong Zhang, Zhenyu Liu, Jihong Zhu, Jan G Korvink Publié dans: Structural and Multidisciplinary Optimization, Issue 61, 2020, Page(s) 2523-2556, ISSN 1615-1488 Éditeur: Springer DOI: 10.1007/s00158-020-02558-8 Conference proceedings (2) Optical gauge head to evaluate gradient field induced vibrations of conductive structures during MRI Auteurs: E. Fuhrer, M. Jouda, O. G. Gruschke, J. G. Korvink Publié dans: 2017 International Conference on Electromagnetics in Advanced Applications (ICEAA), Issue 17244572, 2017, Page(s) 1555-1558, ISBN 978-1-5090-4451-1 Éditeur: IEEE DOI: 10.1109/iceaa.2017.8065581 Wireless closed-loop control of centrifugo-pneumatic valving towards large-scale microfluidic process integration Auteurs: David J. Kinahan, Sarai M. Delgado, Lourdes A.N. Julius, Adam Mallette, David Saenz-Ardila, Rohit Mishra, Celina M. Miyazaki, Jan Korvink, Dario Mager, Jens Ducree Publié dans: 2018 IEEE Micro Electro Mechanical Systems (MEMS), Issue 17733066, 2018, Page(s) 1213-1216, ISBN 978-1-5386-4782-0 Éditeur: IEEE DOI: 10.1109/memsys.2018.8346781 Non-peer reviewed articles (1) Microfluidics featuring multilayered hydrogel assemblies enable real-time NMR-monitoring of enzyme cascade reactions Auteurs: Nurdiana Nordin, Hossein Davoodi, Novindi Dwi Ratnawati, Gudrun Gygli, Jan G Korvink, Vlad Badilita, Neil MacKinnon Publié dans: ChemRxiv, Issue 00000000, 2021, ISSN 0000-0000 Éditeur: ACS Book chapters (1) Ex Vivo Model in Cholestasis Research Auteurs: Ruby E. H. Karsten, Dorenda Oosterhuis, Louise A. van Wijk, Peter Olinga Publié dans: Experimental Cholestasis Research, Issue 1981, 2019, Page(s) 351-362, ISBN 978-1-4939-9419-9 Éditeur: Springer New York DOI: 10.1007/978-1-4939-9420-5_23 Recherche de données OpenAIRE... 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