Objective The ability to handle and operate on cells is an emerging technology that will accelerate the development of novel cell-based therapies. By being able to modify donor cells in-vitro to fight disease more effectively and in volume will have paradigm shifting advances in a wide range of fields such as biotechnology, pharmacology, agriculture, oncology, genetics and embryology. As highlighted by the Innovate UK Cell Therapy Catapult, by 2017 the cell-based therapy manufacturing industry will be worth more than €4.5billion. To realise this opportunity, it is vital clinicians and manufacturers have access to efficient tools that are also repeatable. Several methods exist that enable the manual manipulation of cells, amongst which microinjection tasks is the most common. However, current techniques are labour intensive, vary in quality, and lack the measurement of force between the tools used and the cell needed to reduce damage during contact. Moreover, as these processes are not automated and can only be performed one cell at a time, it is prohibitively expensive to produce new cell-based therapies at the volumes needed for clinical trials. To address these unmet needs, we present ‘HapticCell’, a robotic micromanipulation platform for low cost autonomous microinjection tasks. In this ERC-PoC project, we will extend our ERC research in telehaptic micromanipulation to support schemes for automation and establish its technical feasibility in performing repeatable microinjection tasks in volume appropriate for clinical needs. Further, in collaboration with spin out company Yantric, UCL Business and identified first customers, we will conduct the necessary commercial activities to translate HapticCell into the real world. To start, we envisage HapticCell to be an indispensable tool for achieving higher throughput in the in-vitro fertilisation (IVF) market, which will then act as a stepping stone into the broader single cell manipulation domain and cell-therapy production. Fields of science medical and health sciencesclinical medicinegynaecologyreproductive medicinemedical and health sciencesclinical medicineoncologymedical and health sciencesclinical medicineembryologymedical and health sciencesmedical biotechnologycells technologiesmedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-PoC-2016 - ERC-Proof of Concept-2016 Call for proposal ERC-2016-PoC See other projects for this call Funding Scheme ERC-POC - Proof of Concept Grant Coordinator UNIVERSITY COLLEGE LONDON Net EU contribution € 128 016,00 Address Gower street WC1E 6BT London United Kingdom See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY COLLEGE LONDON United Kingdom Net EU contribution € 128 016,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 YANTRIC INC FOR PROFIT CORPORATION United States Net EU contribution € 21 966,00 Address Cross street 31 02465 West newton ma See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
