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The role of non coding RNA in organismal ageing

Objective

The DNA damage response (DDR) is a set of cellular events that follow the generation of a DNA damage. We have previously discovered a novel class of small non-coding RNAs, named DNA damage RNAs (DDRNAs), which are necessary for the full DDR activation upon a DNA double-strand break generation. Our preliminary data show that also at damaged/dysfunctional telomeres telomeric transcrips are produced. By using antisense oligonucleotides (ASOs) targeting them, we aim at modulating DDR in cultured cells and in vivo in animal models.

Fields of science (EuroSciVoc)

Programme(s)

Topic(s)

Funding Scheme

ERC-POC - Proof of Concept Grant

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Call for proposal

(opens in new window) ERC-2016-PoC

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Host institution

IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Net EU contribution
€ 109 950,00
Address
VIA ADAMELLO 16
20139 Milano
Italy
Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Links
Total cost
€ 149 950,00

Beneficiaries (2)