Periodic Reporting for period 1 - AIM (Adaptive Imaging Microscopy)
Reporting period: 2017-05-01 to 2018-10-31
In the Adaptive Imaging Microscope (AIM) project we have developed a modular light-sheet add-on system, for 3D-sectioning microscopy, that includes single-mode illumination unit, light-sheet forming optics, customized sample chamber and adaptive feedback-based sample control. The system is able to supplement the light-sheet 3D-sectioning functionality and adaptive sample control to the majority of existing biological microscopes: Leica, Olympus, Nikon. The prototype of the system has been developed, fabricated, tested at TU Delft, and transferred to Leiden University for further tests and troubleshooting. The system remains in ongoing development, the updated information on the system technical state and its commercial availability can be obtained from http://delftmicro.com(opens in new window). The fabricated prototype serves as the base for further commercial development in the course of the project:
- Adaptive control of the light-sheet using liquid crystal SLM, aimed to the improvement of light-sheet parameters and forming the required distribution of the complex amplitude of coherent light in the input and output of the multimide waveguide.
- Practical beam delivery through a multimode waveguide structure formed either by a planar glass waveguide, or a waveguide optical system formed by a plurality of GRIN lenses. This solution facilitates the increased distance between the illumination micro-objective and the sample, extending the practical applicability of the light-sheet microscopy.
The solutions listed above define the course of further commercial development of the system. The IP is secured by the patent application "Light Sheet Microscope System", submitted to Dutch patent office in Sep 2018.
- Adaptive control of the light-sheet using liquid crystal SLM, aimed to the improvement of light-sheet parameters and forming the required distribution of the complex amplitude of coherent light in the input and output of the multimide waveguide.
- Practical beam delivery through a multimode waveguide structure formed either by a planar glass waveguide, or a waveguide optical system formed by a plurality of GRIN lenses. This solution facilitates the increased distance between the illumination micro-objective and the sample, extending the practical applicability of the light-sheet microscopy.
The solutions listed above define the course of further commercial development of the system. The IP is secured by the patent application "Light Sheet Microscope System", submitted to Dutch patent office in Sep 2018.