Objective
"In MACULA2 we aim to develop a genetic diagnostic test for complement activation that will allow proper stratification of patients with age-related macular degeneration (AMD). AMD is an inflammatory disease, the #1 cause of blindness in the world, with 196 million patients estimated for 2020. Such a test does not currently exist, strongly hampering drug development and patient treatment. Poor patient stratification contributes to high failure rates in trials for AMD. Local and systemic inflammation in AMD are caused by deregulated activation of the alternative pathway of the complement system. In AMD, some patients have higher complement activation levels compared to controls, which stimulates further inflammation. Several complement-lowering therapies for AMD are under development. Pharmaceutical companies are aware that patients with a genetic predisposition to higher complement activation levels will potentially benefit most from such treatments. Without sound patient stratification, therapies that are currently in clinical trials may not reach the statistical significance needed for approval. However, certain individuals might actually benefit from these therapies because of their specific genetic makeup. We aim to solve the challenge of patient stratification in AMD by developing a novel diagnostic test based on genetic testing combined with a patient questionnaire. An AMD diagnostic test will contribute towards a precision medicine approach towards treatment of patients."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences health sciences personalized medicine
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2016-PoC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.