Objetivo We propose to undertake an ambitious 5-year multidisciplinary programme that seeks to pioneer and establish a fundamentally new paradigm in protolife research that is based on novel conceptual and experimental advances in the design and construction of rudimentary forms of synthetic cell-like micro-ensembles (protocells). Our approach is positioned at the interface between materials chemistry, soft matter science and synthetic biology, and will address the following aspects of protocell design and construction: (i) functional complexity in protocell phenotypes, (ii) protocell self-structuring and metamorphosis, (iii) multi-compartmentalization and protocell endosymbiosis, and (iv) collective behavior in protocell communities. We will initiate unprecedented increases in the complexity of individual protocells by developing new types of structural architectures with advanced functions including photosynthetic protocells and motile proteinosomes, and develop innovative strategies for the chemical secretion of spatially extended extra-protocellular hydrogel matrices and induction of protocell metamorphosis. We will develop a modular micro-engineering approach to protocell multi-compartmentalization with the aim of generating coordinated enzyme- and gene-activated endosymbiotic interactions, and pioneer the experimental study of collective behaviour in communities of synthetic protocells. Our overall aim is to pioneer a modern approach to synthetic cellularity that advances the chemical and physical basis of protocell structure and function, and spearheads the development of future technologies based on autonomously functioning chemical micro-compartments with applications in bioinspired micro-storage and delivery, micro-reactor technologies, cytomimetic engineering, and the development of integrated constructs for diverse procedures in synthetic biology. Ámbito científico ciencias naturalesciencias biológicasbiología sintéticaciencias naturalesciencias físicasfísica de la materia condensadafísica de la materia blandaciencias naturalesciencias biológicasbioquímicabiomoléculasproteínasenzima Programa(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Tema(s) ERC-2016-ADG - ERC Advanced Grant Convocatoria de propuestas ERC-2016-ADG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-ADG - Advanced Grant Coordinador UNIVERSITY OF BRISTOL Aportación neta de la UEn € 2 499 238,00 Dirección Beacon house queens road BS8 1QU Bristol Reino Unido Ver en el mapa Región South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Otras fuentes de financiación € 0,00 Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo UNIVERSITY OF BRISTOL Reino Unido Aportación neta de la UEn € 2 499 238,00 Dirección Beacon house queens road BS8 1QU Bristol Ver en el mapa Región South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Otras fuentes de financiación € 0,00
