Control of cerebral blood flow by capillary pericytes in health and disease

Project Information

BrainEnergy

Grant agreement ID: 740427

DOI

10.3030/740427

Project closed

EC signature date 21 August 2017

Start date 1 September 2017

End date 29 February 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 954,00

EU contribution

€ 2 499 954,00

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis

Author(s): Hirunpattarasilp C, Shiina H, Na-Ek N, Attwell D.
Published in: Neurocritical Care, 2022, ISSN 1556-0961
Publisher: Springer
DOI: 10.1007/s12028-021-01423-w

A tight squeeze: how do we make sense of small changes in microvascular diameter?

Author(s): Davis H, Attwell D.
Published in: Journal of Physiology, Issue 601, 2023, Page(s) 2263-2272, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp284207

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

Author(s): Paterson RW, Brown RL, Benjamin L, Nortley R, Wiethoff S, Bharucha T, Jayaseelan DL, Kumar G, Raftopoulos RE, Zambreanu L, Vivekanandam V, Khoo A, Geraldes R, Chinthapalli K, Boyd E, Tuzlali H, Price G, Christofi G, Morrow J, McNamara P, McLoughlin B, Lim ST, Mehta PR, Levee V, Keddie S, Yong W, Trip SA, Foulkes AJM, Hotton G, Miller TD, Everitt AD, Carswell C, Davies NWS, Yoong M, Attwell D, Sree
Published in: Brain, 2020, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awaa240

Mural cell calcium channels reduce cerebral blood flow, increase hypoxia and promote immune cell stalling in capillaries in Alzheimer’s disease

Author(s): Korte N, Barkaway A, Wells J, Freitas F, Sethi H, Andrews SP, Skidmore J, Stevens B, Attwell D
Published in: Nature Neuroscience, Issue Accepted subject to minor changes, 2024, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01753-w

Immune–vascular mural cell interactions: consequences for immune cell trafficking, cerebral blood flow, and the blood–brain barrier

Author(s): Anna Barkaway, David Attwell, Nils Korte
Published in: Neurophotonics, Issue 9, 2022, Page(s) 031914, ISSN 2329-423X
Publisher: SPIE
DOI: 10.1117/1.nph.9.3.031914

Gradual Not Sudden Change: Multiple Sites of Functional Transition Across the Microvascular Bed

Author(s): Kira Shaw; Katie Boyd; Silvia Anderle; Matthew Hammond-Haley; Davina Amin; Orla Bonnar; Catherine N. Hall
Published in: Frontiers in Aging Neuroscience, Issue 1, 2021, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.779823

Astrocyte Ca 2+-evoked ATP release regulates myelinated axon excitability and conduction speed

Author(s): Lezmy J, Arancibia-Cárcamo IL, Quintela-López T, Sherman DL, Brophy PJ, Attwell D.
Published in: Science, Issue 374(6565), 2021, Page(s) eabh2858, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abh2858

Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α2 adrenergic receptors

Author(s): Korte N, James G, You H, Hirunpattarasilp C, Christie I, Sethi H, Attwell D.
Published in: Journal of Cerebral Blood Flow and Metabolism, Issue 43, 2023, Page(s) 1142-1152, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x231152

Synapse development is regulated by microglial THIK-1 K+ channels.

Author(s): Izquierdo P, Shiina H, Hirunpattarasilp C, Gillis G, Attwell D
Published in: PNAS, Issue 118, 2021, Page(s) e2106294118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2106294118

Hyperoxia evokes pericyte-mediated capillary constriction

Author(s): Hirunpattarasilp C, James G, Kwanthongdee J, Freitas F, Huo J, Sethi H, Kittler JT, Owens RJ, McCoy LE, Attwell D.
Published in: Journal of Cerebral Blood Flow and Metabolism, Issue 42, 2022, Page(s) 2032-2047, ISSN 1559-7016
Publisher: Sage
DOI: 10.1177/0271678x221111598

P2Y 13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release

Author(s): Kyrargyri V, Madry C, Rifat A, Arancibia-Carcamo IL, Jones SP, Chan VTT, Xu Y, Robaye B, Attwell D.
Published in: Glia, Issue 68(2), 2020, Page(s) 328-344, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23719

Diverse mechanisms regulating brain energy supply at the capillary level

Author(s): Pfeiffer T, Li Y, Attwell D.
Published in: Current opinion in Neurobiology, 2021, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2020.12.010

The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia

Author(s): Korte N, Ilkan Z, Pearson CL, Pfeiffer T, Singhal P, Rock JR, Sethi H, Gill D, Attwell D, Tammaro P.
Published in: Journal of Clinical Investigation, Issue 22, 2022, Page(s) e154118, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci154118

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

Author(s): Anusha Mishra, James P Reynolds, Yang Chen, Alexander V Gourine, Dmitri A Rusakov, David Attwell
Published in: Nature Neuroscience, Issue 19/12, 2016, Page(s) 1619-1627, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/nn.4428

Control of brain energy supply by astrocytes

Author(s): Ross Nortley, David Attwell
Published in: Current Opinion in Neurobiology, Issue 47, 2017, Page(s) 80-85, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2017.09.012

Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion

Author(s): Christian Madry, I. Lorena Arancibia-Cárcamo, Vasiliki Kyrargyri, Victor T. T. Chan, Nicola B. Hamilton, David Attwell
Published in: Proceedings of the National Academy of Sciences, Issue 115/7, 2018, Page(s) E1608-E1617, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1715354115

Targeting pericytes for therapeutic approaches to neurological disorders

Author(s): Jinping Cheng, Nils Korte, Ross Nortley, Huma Sethi, Yamei Tang, David Attwell
Published in: Acta Neuropathologica, 2018, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-018-1893-0

Ion Channels and Receptors as Determinants of Microglial Function

Author(s): Pablo Izquierdo, David Attwell, Christian Madry
Published in: Trends in Neurosciences, Issue 42/4, 2019, Page(s) 278-292, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2018.12.007

Energy-efficient information transfer at thalamocortical synapses

Author(s): Julia Jade Harris, Elisabeth Engl, David Attwell, Renaud Blaise Jolivet
Published in: PLOS Computational Biology, Issue 15/8, 2019, Page(s) e1007226, ISSN 1553-7358
Publisher: PLoS (PLoS Comp Biol)
DOI: 10.1371/journal.pcbi.1007226

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

Author(s): Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C. Saido, Sebastian Brandner, Huma Sethi, David Attwell
Published in: Science, Issue 365/6450, 2019, Page(s) eaav9518, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aav9518

Optimising the energetic cost of the glutamatergic synapse

Author(s): Lezmy J, Harris JJ, Attwell D.
Published in: Neuropharmacology, 2021, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2021.108727

Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

Author(s): Freitas F, Attwell D
Published in: eLife, Issue 11, 2022, Page(s) e74211, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.74211

Amyloid plaques and normal ageing have differential effects on microglial Ca2+ activity in the mouse brain

Author(s): Izquierdo P, Jolivet RB, Attwell D, Madry C.
Published in: Pfluegers Archiv, Issue 476, 2024, Page(s) 257-270, ISSN 0031-6768
Publisher: Springer Verlag
DOI: 10.1007/s00424-023-02871-3

Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease

Author(s): Nils Korte, Ross Nortley, David Attwell
Published in: Acta Neuropathologica, Issue 2020, 2020, Page(s) TBA, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02215-w

SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction

Author(s): Hirunpattarasilp C, Barkaway A, Davis H, Pfeiffer T, Sethi H, Attwell D.
Published in: Brain, Issue 146, 2022, Page(s) 727-738, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac272