Control of cerebral blood flow by capillary pericytes in health and disease

Informazioni relative al progetto

BrainEnergy

ID dell’accordo di sovvenzione: 740427

DOI

10.3030/740427

Progetto chiuso

Data della firma CE 21 Agosto 2017

Data di avvio 1 Settembre 2017

Data di completamento 29 Febbraio 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 954,00

Contributo UE

€ 2 499 954,00

Coordinato da

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (25)

The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis

Autori: Hirunpattarasilp C, Shiina H, Na-Ek N, Attwell D.
Pubblicato in: Neurocritical Care, 2022, ISSN 1556-0961
Editore: Springer
DOI: 10.1007/s12028-021-01423-w

A tight squeeze: how do we make sense of small changes in microvascular diameter?

Autori: Davis H, Attwell D.
Pubblicato in: Journal of Physiology, Numero 601, 2023, Pagina/e 2263-2272, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp284207

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

Autori: Paterson RW, Brown RL, Benjamin L, Nortley R, Wiethoff S, Bharucha T, Jayaseelan DL, Kumar G, Raftopoulos RE, Zambreanu L, Vivekanandam V, Khoo A, Geraldes R, Chinthapalli K, Boyd E, Tuzlali H, Price G, Christofi G, Morrow J, McNamara P, McLoughlin B, Lim ST, Mehta PR, Levee V, Keddie S, Yong W, Trip SA, Foulkes AJM, Hotton G, Miller TD, Everitt AD, Carswell C, Davies NWS, Yoong M, Attwell D, Sree
Pubblicato in: Brain, 2020, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaa240

Mural cell calcium channels reduce cerebral blood flow, increase hypoxia and promote immune cell stalling in capillaries in Alzheimer’s disease

Autori: Korte N, Barkaway A, Wells J, Freitas F, Sethi H, Andrews SP, Skidmore J, Stevens B, Attwell D
Pubblicato in: Nature Neuroscience, Numero Accepted subject to minor changes, 2024, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-024-01753-w

Immune–vascular mural cell interactions: consequences for immune cell trafficking, cerebral blood flow, and the blood–brain barrier

Autori: Anna Barkaway, David Attwell, Nils Korte
Pubblicato in: Neurophotonics, Numero 9, 2022, Pagina/e 031914, ISSN 2329-423X
Editore: SPIE
DOI: 10.1117/1.nph.9.3.031914

Gradual Not Sudden Change: Multiple Sites of Functional Transition Across the Microvascular Bed

Autori: Kira Shaw; Katie Boyd; Silvia Anderle; Matthew Hammond-Haley; Davina Amin; Orla Bonnar; Catherine N. Hall
Pubblicato in: Frontiers in Aging Neuroscience, Numero 1, 2021, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.779823

Astrocyte Ca 2+-evoked ATP release regulates myelinated axon excitability and conduction speed

Autori: Lezmy J, Arancibia-Cárcamo IL, Quintela-López T, Sherman DL, Brophy PJ, Attwell D.
Pubblicato in: Science, Numero 374(6565), 2021, Pagina/e eabh2858, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abh2858

Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α2 adrenergic receptors

Autori: Korte N, James G, You H, Hirunpattarasilp C, Christie I, Sethi H, Attwell D.
Pubblicato in: Journal of Cerebral Blood Flow and Metabolism, Numero 43, 2023, Pagina/e 1142-1152, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x231152

Synapse development is regulated by microglial THIK-1 K+ channels.

Autori: Izquierdo P, Shiina H, Hirunpattarasilp C, Gillis G, Attwell D
Pubblicato in: PNAS, Numero 118, 2021, Pagina/e e2106294118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2106294118

Hyperoxia evokes pericyte-mediated capillary constriction

Autori: Hirunpattarasilp C, James G, Kwanthongdee J, Freitas F, Huo J, Sethi H, Kittler JT, Owens RJ, McCoy LE, Attwell D.
Pubblicato in: Journal of Cerebral Blood Flow and Metabolism, Numero 42, 2022, Pagina/e 2032-2047, ISSN 1559-7016
Editore: Sage
DOI: 10.1177/0271678x221111598

P2Y 13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release

Autori: Kyrargyri V, Madry C, Rifat A, Arancibia-Carcamo IL, Jones SP, Chan VTT, Xu Y, Robaye B, Attwell D.
Pubblicato in: Glia, Numero 68(2), 2020, Pagina/e 328-344, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.23719

Diverse mechanisms regulating brain energy supply at the capillary level

Autori: Pfeiffer T, Li Y, Attwell D.
Pubblicato in: Current opinion in Neurobiology, 2021, ISSN 0959-4388
Editore: Elsevier BV
DOI: 10.1016/j.conb.2020.12.010

The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia

Autori: Korte N, Ilkan Z, Pearson CL, Pfeiffer T, Singhal P, Rock JR, Sethi H, Gill D, Attwell D, Tammaro P.
Pubblicato in: Journal of Clinical Investigation, Numero 22, 2022, Pagina/e e154118, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci154118

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

Autori: Anusha Mishra, James P Reynolds, Yang Chen, Alexander V Gourine, Dmitri A Rusakov, David Attwell
Pubblicato in: Nature Neuroscience, Numero 19/12, 2016, Pagina/e 1619-1627, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/nn.4428

Control of brain energy supply by astrocytes

Autori: Ross Nortley, David Attwell
Pubblicato in: Current Opinion in Neurobiology, Numero 47, 2017, Pagina/e 80-85, ISSN 0959-4388
Editore: Elsevier BV
DOI: 10.1016/j.conb.2017.09.012

Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion

Autori: Christian Madry, I. Lorena Arancibia-Cárcamo, Vasiliki Kyrargyri, Victor T. T. Chan, Nicola B. Hamilton, David Attwell
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 115/7, 2018, Pagina/e E1608-E1617, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1715354115

Targeting pericytes for therapeutic approaches to neurological disorders

Autori: Jinping Cheng, Nils Korte, Ross Nortley, Huma Sethi, Yamei Tang, David Attwell
Pubblicato in: Acta Neuropathologica, 2018, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-018-1893-0

Ion Channels and Receptors as Determinants of Microglial Function

Autori: Pablo Izquierdo, David Attwell, Christian Madry
Pubblicato in: Trends in Neurosciences, Numero 42/4, 2019, Pagina/e 278-292, ISSN 0166-2236
Editore: Elsevier BV
DOI: 10.1016/j.tins.2018.12.007

Energy-efficient information transfer at thalamocortical synapses

Autori: Julia Jade Harris, Elisabeth Engl, David Attwell, Renaud Blaise Jolivet
Pubblicato in: PLOS Computational Biology, Numero 15/8, 2019, Pagina/e e1007226, ISSN 1553-7358
Editore: PLoS (PLoS Comp Biol)
DOI: 10.1371/journal.pcbi.1007226

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

Autori: Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C. Saido, Sebastian Brandner, Huma Sethi, David Attwell
Pubblicato in: Science, Numero 365/6450, 2019, Pagina/e eaav9518, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aav9518

Optimising the energetic cost of the glutamatergic synapse

Autori: Lezmy J, Harris JJ, Attwell D.
Pubblicato in: Neuropharmacology, 2021, ISSN 0028-3908
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2021.108727

Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

Autori: Freitas F, Attwell D
Pubblicato in: eLife, Numero 11, 2022, Pagina/e e74211, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.74211

Amyloid plaques and normal ageing have differential effects on microglial Ca2+ activity in the mouse brain

Autori: Izquierdo P, Jolivet RB, Attwell D, Madry C.
Pubblicato in: Pfluegers Archiv, Numero 476, 2024, Pagina/e 257-270, ISSN 0031-6768
Editore: Springer Verlag
DOI: 10.1007/s00424-023-02871-3

Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease

Autori: Nils Korte, Ross Nortley, David Attwell
Pubblicato in: Acta Neuropathologica, Numero 2020, 2020, Pagina/e TBA, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-020-02215-w

SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction

Autori: Hirunpattarasilp C, Barkaway A, Davis H, Pfeiffer T, Sethi H, Attwell D.
Pubblicato in: Brain, Numero 146, 2022, Pagina/e 727-738, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac272