Decomposition of pain into celltypes

Project Information

PainCells

Grant agreement ID: 740491

DOI 10.3030/740491

Project closed

EC signature date 10 July 2017

Start date 1 August 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 443 952,50

EU contribution € 2 443 952,50

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Publications

Non-peer reviewed articles (3)

Molecular taxonomy of nociceptors and pruriceptors

Author(s): Jussi Kupari 1, Patrik Ernfors
Published in: Pain, 2023, Page(s) 1245-1257, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002831

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

Author(s): Jussi Kupari, Dmitry Usoskin, Marc Parisien, Daohua Lou, Yizhou Hu, Michael Fatt, Peter Lönnerberg, Mats Spångberg, Bengt Eriksson, Nikolaos Barkas, Peter V Kharchenko, Karin Loré, Samar Khoury, Luda Diatchenko, Patrik Ernfors
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21725-z

Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia

Author(s): Puneet Rinwa, Laura Calvo-Enrique, Ming-Dong Zhang, Jens Randel Nyengaard, Páll Karlsson, Patrik Ernfors
Published in: Pain, 2022, Page(s) 1816-1827, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002169

Peer reviewed articles (11)

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes

Author(s): Changgeng Peng, Lili Li, Ming-Dong Zhang, Carolina Bengtsson Gonzales, Marc Parisien, Inna Belfer, Dmitry Usoskin, Hind Abdo, Alessandro Furlan, Martin Häring, Francois Lallemend, Tibor Harkany, Luda Diatchenko, Tomas Hökfelt, Jens Hjerling-Leffler, Patrik Ernfors
Published in: Science, Issue 356/6343, 2017, Page(s) 1168-1171, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aam7671

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla

Author(s): Alessandro Furlan, Vyacheslav Dyachuk, Maria Eleni Kastriti, Laura Calvo-Enrique, Hind Abdo, Saida Hadjab, Tatiana Chontorotzea, Natalia Akkuratova, Dmitry Usoskin, Dmitry Kamenev, Julian Petersen, Kazunori Sunadome, Fatima Memic, Ulrika Marklund, Kaj Fried, Piotr Topilko, Francois Lallemend, Peter V. Kharchenko, Patrik Ernfors, Igor Adameyko
Published in: Science, Issue 357/6346, 2017, Page(s) eaal3753, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aal3753

Molecular Architecture of the Mouse Nervous System

Author(s): Amit Zeisel, Hannah Hochgerner, Peter Lönnerberg, Anna Johnsson, Fatima Memic, Job van der Zwan, Martin Häring, Emelie Braun, Lars E. Borm, Gioele La Manno, Simone Codeluppi, Alessandro Furlan, Kawai Lee, Nathan Skene, Kenneth D. Harris, Jens Hjerling-Leffler, Ernest Arenas, Patrik Ernfors, Ulrika Marklund, Sten Linnarsson
Published in: Cell, Issue 174/4, 2018, Page(s) 999-1014.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.06.021

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

Author(s): Martin Häring, Amit Zeisel, Hannah Hochgerner, Puneet Rinwa, Jon E. T. Jakobsson, Peter Lönnerberg, Gioele La Manno, Nilesh Sharma, Lotta Borgius, Ole Kiehn, Malin C. Lagerström, Sten Linnarsson, Patrik Ernfors
Published in: Nature Neuroscience, Issue 21/6, 2018, Page(s) 869-880, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0141-1

Nerves Do It Again: Donation of Mesenchymal Cells for Tissue Regeneration

Author(s): Igor Adameyko, Patrik Ernfors
Published in: Cell Stem Cell, Issue 24/2, 2019, Page(s) 195-197, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2019.01.006

Termination of cell-type specification gene programs by the miR-183 cluster determines the population sizes of low-threshold mechanosensitive neurons

Author(s): Changgeng Peng, Alessandro Furlan, Ming-Dong Zhang, Jie Su, Moritz Lübke, Peter Lönnerberg, Hind Abdo, Jana Sontheimer, Erik Sundström, Patrik Ernfors
Published in: Development, Issue 145/18, 2018, Page(s) dev165613, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.165613

An Atlas of Vagal Sensory Neurons and Their Molecular Specialization

Author(s): Jussi Kupari, Martin Häring, Eneritz Agirre, Gonçalo Castelo-Branco, Patrik Ernfors
Published in: Cell Reports, Issue 27/8, 2019, Page(s) 2508-2523.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.04.096

Specialized cutaneous Schwann cells initiate pain sensation

Author(s): Hind Abdo, Laura Calvo-Enrique, Jose Martinez Lopez, Jianren Song, Ming-Dong Zhang, Dmitry Usoskin, Abdeljabbar El Manira, Igor Adameyko, Jens Hjerling-Leffler, Patrik Ernfors
Published in: Science, Issue 365/6454, 2019, Page(s) 695-699, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax6452

NoRC Recruitment by H2A.X Deposition at rRNA Gene Promoter Limits Embryonic Stem Cell Proliferation

Author(s): Boris Eleuteri, Sergi Aranda, Patrik Ernfors
Published in: Cell Reports, Issue 23/6, 2018, Page(s) 1853-1866, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.04.023

PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis

Author(s): Luca Bartesaghi, Yiqiao Wang, Paula Fontanet, Simone Wanderoy, Finja Berger, Haohao Wu, Natalia Akkuratova, Filipa Bouçanova, Jean-Jacques Médard, Charles Petitpré, Mark A. Landy, Ming-Dong Zhang, Philip Harrer, Claudia Stendel, Rolf Stucka, Marina Dusl, Maria Eleni Kastriti, Laura Croci, Helen C. Lai, Gian Giacomo Consalez, Alexandre Pattyn, Patrik Ernfors, Jan Senderek, Igor Adameyko, Francoi
Published in: Cell Reports, Issue 26/13, 2019, Page(s) 3484-3492.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.02.098

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Author(s): Falcão AM, Meijer M, Scaglione A, Rinwa P, Agirre E, Liang J, Larsen SC, Heskol A, Frawley R, Klingener M, Varas-Godoy M, Raposo AASF, Ernfors P, Castro DS, Nielsen ML, Casaccia P, Castelo-Branco G.
Published in: Cell Reports, 2019, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.03.108

Other (1)

Pricking into Autonomic Reflex Pathways by Electrical Acupuncture

Author(s): Jussi Kupari, Patrik Ernfors
Published in: Neuron, 2020, Page(s) 395-397, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.09.026