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Deconstructing Ageing: from molecular mechanisms to intervention strategies

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Publications

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

Author(s): Clea Bárcena, Pedro M. Quirós, Sylvère Durand, Pablo Mayoral, Francisco Rodríguez, Xurde M. Caravia, Guillermo Mariño, Cecilia Garabaya, María Teresa Fernández-García, Guido Kroemer, José M.P. Freije, Carlos López-Otín
Published in: Cell Reports, Issue 24/9, 2018, Page(s) 2392-2403, ISSN 2211-1247
DOI: 10.1016/j.celrep.2018.07.089

Mouse Models to Disentangle the Hallmarks of Human Aging

Author(s): Alicia R. Folgueras, Sandra Freitas-Rodríguez, Gloria Velasco, Carlos López-Otín
Published in: Circulation Research, Issue 123/7, 2018, Page(s) 905-924, ISSN 0009-7330
DOI: 10.1161/circresaha.118.312204

The Novel Evolution of the Sperm Whale Genome

Author(s): Wesley C Warren, Lukas Kuderna, Alana Alexander, Julian Catchen, José G Pérez-Silva, Carlos López-Otín, Víctor Quesada, Patrick Minx, Chad Tomlinson, Michael J Montague, Fabiana H G Farias, Ronald B Walter, Tomas Marques-Bonet, Travis Glenn, Troy J Kieran, Sandra S Wise, John Pierce Wise, Robert M Waterhouse, John Pierce Wise
Published in: Genome Biology and Evolution, Issue 9/12, 2017, Page(s) 3260-3264, ISSN 1759-6653
DOI: 10.1093/gbe/evx187

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function

Author(s): Xurde M. Caravia, Víctor Fanjul, Eduardo Oliver, David Roiz-Valle, Alba Morán-Álvarez, Gabriela Desdín-Micó, María Mittelbrunn, Roberto Cabo, José A. Vega, Francisco Rodríguez, Antonio Fueyo, Mónica Gómez, Manuel Lobo-González, Héctor Bueno, Gloria Velasco, José M. P. Freije, Vicente Andrés, Borja Ibáñez, Alejandro P. Ugalde, Carlos López-Otín
Published in: PLOS Biology, Issue 16/10, 2018, Page(s) e2006247, ISSN 1544-9173
DOI: 10.1371/journal.pbio.2006247

The role of matrix metalloproteinases in aging: Tissue remodeling and beyond

Author(s): Sandra Freitas-Rodríguez, Alicia R. Folgueras, Carlos López-Otín
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1864/11, 2017, Page(s) 2015-2025, ISSN 0167-4889
DOI: 10.1016/j.bbamcr.2017.05.007

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

Author(s): Sundararajan Venkatesh, Min Li, Toshiro Saito, Mingming Tong, Eman Rashed, Satvik Mareedu, Peiyong Zhai, Clea Bárcena, Carlos López-Otín, Ghassan Yehia, Junichi Sadoshima, Carolyn K. Suzuki
Published in: Journal of Molecular and Cellular Cardiology, Issue 128, 2019, Page(s) 38-50, ISSN 0022-2828
DOI: 10.1016/j.yjmcc.2018.12.017

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

Author(s): Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés
Published in: EMBO Molecular Medicine, Issue 11/4, 2019, ISSN 1757-4676
DOI: 10.15252/emmm.201809736

Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome

Author(s): Olaya Santiago-Fernández, Fernando G. Osorio, Víctor Quesada, Francisco Rodríguez, Sammy Basso, Daniel Maeso, Loïc Rolas, Anna Barkaway, Sussan Nourshargh, Alicia R. Folgueras, José M. P. Freije, Carlos López-Otín
Published in: Nature Medicine, Issue 25/3, 2019, Page(s) 423-426, ISSN 1078-8956
DOI: 10.1038/s41591-018-0338-6

Giant tortoise genomes provide insights into longevity and age-related disease

Author(s): Víctor Quesada, Sandra Freitas-Rodríguez, Joshua Miller, José G. Pérez-Silva, Zi-Feng Jiang, Washington Tapia, Olaya Santiago-Fernández, Diana Campos-Iglesias, Lukas F. K. Kuderna, Maud Quinzin, Miguel G. Álvarez, Dido Carrero, Luciano B. Beheregaray, James P. Gibbs, Ylenia Chiari, Scott Glaberman, Claudio Ciofi, Miguel Araujo-Voces, Pablo Mayoral, Javier R. Arango, Isaac Tamargo-Gómez, Dav
Published in: Nature Ecology & Evolution, Issue 3/1, 2019, Page(s) 87-95, ISSN 2397-334X
DOI: 10.1038/s41559-018-0733-x

Carbotoxicity—Noxious Effects of Carbohydrates

Author(s): Guido Kroemer, Carlos López-Otín, Frank Madeo, Rafael de Cabo
Published in: Cell, Issue 175/3, 2018, Page(s) 605-614, ISSN 0092-8674
DOI: 10.1016/j.cell.2018.07.044

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

Author(s): Holly Whitton, Larry N. Singh, Marissa A. Patrick, Andrew J. Price, Fernando G. Osorio, Carlos López-Otín, Irina M. Bochkis
Published in: Aging Cell, Issue 17/3, 2018, Page(s) e12742, ISSN 1474-9718
DOI: 10.1111/acel.12742

Functional relevance of miRNAs in premature ageing

Author(s): Xurde M. Caravia, David Roiz-Valle, Alba Morán-Álvarez, Carlos López-Otín
Published in: Mechanisms of Ageing and Development, Issue 168, 2017, Page(s) 10-19, ISSN 0047-6374
DOI: 10.1016/j.mad.2017.05.003

Clonal evolution in leukemia

Author(s): Adolfo A Ferrando, Carlos López-Otín
Published in: Nature Medicine, Issue 23/10, 2017, Page(s) 1135-1145, ISSN 1078-8956
DOI: 10.1038/nm.4410

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Author(s): Clea Bárcena, Rafael Valdés-Mas, Pablo Mayoral, Cecilia Garabaya, Sylvère Durand, Francisco Rodríguez, María Teresa Fernández-García, Nuria Salazar, Alicja M. Nogacka, Nuria Garatachea, Noélie Bossut, Fanny Aprahamian, Alejandro Lucia, Guido Kroemer, José M. P. Freije, Pedro M. Quirós, Carlos López-Otín
Published in: Nature Medicine, Issue 25/8, 2019, Page(s) 1234-1242, ISSN 1078-8956
DOI: 10.1038/s41591-019-0504-5

Differential mechanisms of tolerance to extreme environmental conditions in tardigrades

Author(s): Dido Carrero, José G. Pérez-Silva, Víctor Quesada, Carlos López-Otín
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-51471-8

Decelerating ageing and biological clocks by autophagy

Author(s): Carlos Lopez-Otín, Guido Kroemer
Published in: Nature Reviews Molecular Cell Biology, Issue 20/7, 2019, Page(s) 385-386, ISSN 1471-0072
DOI: 10.1038/s41580-019-0149-8

Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?

Author(s): Clea Bárcena, Carlos López-Otín, Guido Kroemer
Published in: Autophagy, Issue 15/3, 2018, Page(s) 558-559, ISSN 1554-8627
DOI: 10.1080/15548627.2018.1533059

Genome Sequencing and Analysis Methods in Chronic Lymphocytic Leukemia

Author(s): Víctor Quesada, Miguel Araujo-Voces, José G. Pérez-Silva, Gloria Velasco, Carlos López-Otín
Published in: Chronic Lymphocytic Leukemia - Methods and Protocols, Issue 1881, 2019, Page(s) 319-325
DOI: 10.1007/978-1-4939-8876-1_22