Deconstructing Ageing: from molecular mechanisms to intervention strategies

Project Information

DeAge

Grant agreement ID: 742067

DOI

10.3030/742067

Project closed

EC signature date 11 August 2017

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 456 250,00

EU contribution

€ 2 456 250,00

Coordinated by

UNIVERSIDAD DE OVIEDO
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

Meta-hallmarks of aging and cancer

Author(s): López-Otín C, Pietrocola F, Roiz-Valle D, Galluzzi L, Kroemer G.
Published in: Cell metabolism, Issue 35, 2023, Page(s) 12-35, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.11.001

Hallmarks of Health

Author(s): Carlos López-Otín and Guido Kroemer
Published in: Cell, Issue 184, 2021, Page(s) 33-63, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.11.034

Exercise sustains the hallmarks of health

Author(s): Qiu Y, Fernández-García B, Lehmann HI, Li G, Kroemer G, López-Otín C, Xiao J.
Published in: Journal of sport and health science, Issue 12, 2023, Page(s) 8-35, ISSN 2095-2546
Publisher: Elsevier BV
DOI: 10.1016/j.jshs.2022.10.003

USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy

Author(s): Diana Campos-Iglesias; Julia M. Fraile; Gabriel Bretones; Alejandro A. Montero; Elena Bonzon-Kulichenko; Jesús Vázquez; Carlos López-Otín; José M. P. Freije
Published in: Cell death & disease, Issue 14, 2023, Page(s) 60, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-023-05600-x

Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation

Author(s): Maria Pascual-Torner, Dido Carrero, José G Pérez-Silva, Diana Álvarez-Puente, David Roiz-Valle, Gabriel Bretones, David Rodríguez, Daniel Maeso, Elena Mateo-González, Yaiza Español, Guillermo Mariño, José Luis Acuña, Víctor Quesada, Carlos López-Otín
Published in: Proceedings of the National Academy of Sciences of the United States of America., Issue 119, 2022, Page(s) e2118763119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2118763119

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

Author(s): Clea Bárcena, Pedro M. Quirós, Sylvère Durand, Pablo Mayoral, Francisco Rodríguez, Xurde M. Caravia, Guillermo Mariño, Cecilia Garabaya, María Teresa Fernández-García, Guido Kroemer, José M.P. Freije, Carlos López-Otín
Published in: Cell Reports, Issue 24/9, 2018, Page(s) 2392-2403, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.07.089

Mouse Models to Disentangle the Hallmarks of Human Aging

Author(s): Alicia R. Folgueras, Sandra Freitas-Rodríguez, Gloria Velasco, Carlos López-Otín
Published in: Circulation Research, Issue 123/7, 2018, Page(s) 905-924, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.312204

The Novel Evolution of the Sperm Whale Genome

Author(s): Wesley C Warren, Lukas Kuderna, Alana Alexander, Julian Catchen, José G Pérez-Silva, Carlos López-Otín, Víctor Quesada, Patrick Minx, Chad Tomlinson, Michael J Montague, Fabiana H G Farias, Ronald B Walter, Tomas Marques-Bonet, Travis Glenn, Troy J Kieran, Sandra S Wise, John Pierce Wise, Robert M Waterhouse, John Pierce Wise
Published in: Genome Biology and Evolution, Issue 9/12, 2017, Page(s) 3260-3264, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evx187

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function

Author(s): Xurde M. Caravia, Víctor Fanjul, Eduardo Oliver, David Roiz-Valle, Alba Morán-Álvarez, Gabriela Desdín-Micó, María Mittelbrunn, Roberto Cabo, José A. Vega, Francisco Rodríguez, Antonio Fueyo, Mónica Gómez, Manuel Lobo-González, Héctor Bueno, Gloria Velasco, José M. P. Freije, Vicente Andrés, Borja Ibáñez, Alejandro P. Ugalde, Carlos López-Otín
Published in: PLOS Biology, Issue 16/10, 2018, Page(s) e2006247, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.2006247

The role of matrix metalloproteinases in aging: Tissue remodeling and beyond

Author(s): Sandra Freitas-Rodríguez, Alicia R. Folgueras, Carlos López-Otín
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1864/11, 2017, Page(s) 2015-2025, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2017.05.007

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

Author(s): Sundararajan Venkatesh, Min Li, Toshiro Saito, Mingming Tong, Eman Rashed, Satvik Mareedu, Peiyong Zhai, Clea Bárcena, Carlos López-Otín, Ghassan Yehia, Junichi Sadoshima, Carolyn K. Suzuki
Published in: Journal of Molecular and Cellular Cardiology, Issue 128, 2019, Page(s) 38-50, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2018.12.017

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

Author(s): Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés
Published in: EMBO Molecular Medicine, Issue 11/4, 2019, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809736

Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome

Author(s): Olaya Santiago-Fernández, Fernando G. Osorio, Víctor Quesada, Francisco Rodríguez, Sammy Basso, Daniel Maeso, Loïc Rolas, Anna Barkaway, Sussan Nourshargh, Alicia R. Folgueras, José M. P. Freije, Carlos López-Otín
Published in: Nature Medicine, Issue 25/3, 2019, Page(s) 423-426, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0338-6

Giant tortoise genomes provide insights into longevity and age-related disease

Author(s): Víctor Quesada, Sandra Freitas-Rodríguez, Joshua Miller, José G. Pérez-Silva, Zi-Feng Jiang, Washington Tapia, Olaya Santiago-Fernández, Diana Campos-Iglesias, Lukas F. K. Kuderna, Maud Quinzin, Miguel G. Álvarez, Dido Carrero, Luciano B. Beheregaray, James P. Gibbs, Ylenia Chiari, Scott Glaberman, Claudio Ciofi, Miguel Araujo-Voces, Pablo Mayoral, Javier R. Arango, Isaac Tamargo-Gómez, Dav
Published in: Nature Ecology & Evolution, Issue 3/1, 2019, Page(s) 87-95, ISSN 2397-334X
Publisher: Springer Nature
DOI: 10.1038/s41559-018-0733-x

Carbotoxicity—Noxious Effects of Carbohydrates

Author(s): Guido Kroemer, Carlos López-Otín, Frank Madeo, Rafael de Cabo
Published in: Cell, Issue 175/3, 2018, Page(s) 605-614, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.07.044

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

Author(s): Holly Whitton, Larry N. Singh, Marissa A. Patrick, Andrew J. Price, Fernando G. Osorio, Carlos López-Otín, Irina M. Bochkis
Published in: Aging Cell, Issue 17/3, 2018, Page(s) e12742, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.12742

Functional relevance of miRNAs in premature ageing

Author(s): Xurde M. Caravia, David Roiz-Valle, Alba Morán-Álvarez, Carlos López-Otín
Published in: Mechanisms of Ageing and Development, Issue 168, 2017, Page(s) 10-19, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2017.05.003

Clonal evolution in leukemia

Author(s): Adolfo A Ferrando, Carlos López-Otín
Published in: Nature Medicine, Issue 23/10, 2017, Page(s) 1135-1145, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4410

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Author(s): Clea Bárcena, Rafael Valdés-Mas, Pablo Mayoral, Cecilia Garabaya, Sylvère Durand, Francisco Rodríguez, María Teresa Fernández-García, Nuria Salazar, Alicja M. Nogacka, Nuria Garatachea, Noélie Bossut, Fanny Aprahamian, Alejandro Lucia, Guido Kroemer, José M. P. Freije, Pedro M. Quirós, Carlos López-Otín
Published in: Nature Medicine, Issue 25/8, 2019, Page(s) 1234-1242, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0504-5

Differential mechanisms of tolerance to extreme environmental conditions in tardigrades

Author(s): Dido Carrero, José G. Pérez-Silva, Víctor Quesada, Carlos López-Otín
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-51471-8

Decelerating ageing and biological clocks by autophagy

Author(s): Carlos Lopez-Otín, Guido Kroemer
Published in: Nature Reviews Molecular Cell Biology, Issue 20/7, 2019, Page(s) 385-386, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-019-0149-8

Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?

Author(s): Clea Bárcena, Carlos López-Otín, Guido Kroemer
Published in: Autophagy, Issue 15/3, 2018, Page(s) 558-559, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2018.1533059

Hallmarks of aging: An expanding universe

Author(s): López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G.
Published in: Cell, Issue 186, 2023, Page(s) 243-278, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.11.001

The secretome atlas of two mouse models of progeria

Author(s): Quintana-Torres D, Valle-Cao A, Bousquets-Muñoz P, Freitas-Rodríguez S, Rodríguez F, Lucia A, López-Otín C, López-Soto A, Folgueras AR
Published in: Aging cell, Issue e13952, 2023, Page(s) e13952, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13952

Mechanisms of mitochondrial microRNA regulation in cardiovascular diseases

Author(s): David Roiz-Valle, Xurde M Caravia, Carlos López-Otín
Published in: Mechanisms of ageing and development, Issue 212, 2023, Page(s) 111822, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2023.111822

Book chapters (1)

Genome Sequencing and Analysis Methods in Chronic Lymphocytic Leukemia

Author(s): Víctor Quesada, Miguel Araujo-Voces, José G. Pérez-Silva, Gloria Velasco, Carlos López-Otín
Published in: Chronic Lymphocytic Leukemia - Methods and Protocols, Issue 1881, 2019, Page(s) 319-325, ISBN 978-1-4939-8875-4
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8876-1_22