Systems Neuroscience of Metabolism

Project Information

SYNEME

Grant agreement ID: 742106

DOI

10.3030/742106

Project closed

EC signature date 10 July 2017

Start date 1 October 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 212 500,00

EU contribution

€ 2 212 500,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus

Author(s): Lukas Steuernagel, Brian Y. H. Lam, Paul Klemm, Georgina K. C. Dowsett , Corinna A. Bauder, John A. Tadross, Tamara Sotelo Hitschfeld, Almudena del Rio Martin, Weiyi Chen, Alain J. de Solis, Henning Fenselau, Peter Davidsen, Irene Cimino, Sara N. Kohnke, Debra Rimmington, Anthony P. Coll, Andreas Beyer, Giles S. H. Yeo and Jens C. Brüning
Published in: Nature Metabolism, 2022, ISSN 2522-5812
Publisher: Nature Spinger
DOI: 10.1038/s42255-022-00657-y

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

Author(s): Claus Brandt, Hendrik Nolte, Sinika Henschke, Linda Engstroem Ruud, Motoharu Awazawa, Donald A. Morgan, Paula Gabel, Hans-Georg Sprenger, Martin E. Hess, Stefan Günther, Thomas Langer, Kamal Rahmouni, Henning Fenselau, Marcus Krüger, and Jens C. Brüning
Published in: Cell, 2018, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.10.015

Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting

Author(s): Nasim Biglari, Isabella Gaziano, Jonas Schumacher, Jan Radermacher, Lars Paeger, Paul Klemm, Weiyi Chen, Svenja Corneliussen, Claudia M. Wunderlich, Michael Sue, Stefan Vollmar, Tim Klöckener, Tamara Sotelo-Hitschfeld, Amin Abbasloo, Frank Edenhofer, Frank Reimann, Fiona M. Gribble, Henning Fenselau, Peter Kloppenburg, Frank T. Wunderlich & Jens C. Brüning
Published in: Nature Neuroscience, 2021, ISSN 1546-1726
Publisher: Springer Nature
DOI: 10.1038/s41593-021-00854-0

Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature

Author(s): Isabella Gaziano,Svenja Corneliussen,Nasim Biglari, René Neuhaus,Linyan Shen,Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solis, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, and Jens C. Brüning
Published in: JCI Insight, 2022, ISSN 2379-3708
Publisher: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.162753

Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism

Author(s): Borgmann, D., Ciglieri, E., Biglari, N., Brandt, C., Cremer, A.L., Backes, H., Tittgemeyer, M., Wunderlich, F.T., Brüning, J.C., and Fenselau, H.
Published in: Cell Metabolism, 2021, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.05.002

PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding

Author(s): Alexander Jais, Lars Paeger, Tamara Sotelo-Hitschfeld, Stephan Bremser, Melanie Prinzensteiner, Paul Klemm, Vasyl Mykytiuk, Pia J.M. Widdershooven, Anna Juliane Vesting, Katarzyna Grzelka, Marielle Minère, Anna Lena Cremer, Jie Xu, Tatiana Korotkova, Bradford B. Lowell, Hanns Ulrich Zeilhofer, Heiko Backes, Henning Fenselau, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning
Published in: Neuron, Issue 106/6, 2020, Page(s) 1009-1025.e10, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.03.022

Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice

Author(s): R.N. Lippert, S. Hess, P. Klemm, L.M. Burgeno, T. Jahans-Price, M.E. Walton, P. Kloppenburg, J.C. Brüning
Published in: Journal of Clinical Investigation, Issue 130/7, 2020, Page(s) 3761-3776, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci134412

MCH Neurons Regulate Permeability of the Median Eminence Barrier

Author(s): Hong Jiang, Sarah Gallet, Paul Klemm, Pia Scholl, Kat Folz-Donahue, Janine Altmüller, Jens Alber, Christian Heilinger, Christian Kukat, Anne Loyens, Helge Müller-Fielitz, Sivaraj Sundaram, Markus Schwaninger, Vincent Prevot, and Jens C. Brüning
Published in: Neuron, 2020, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.04.020