The molecular and cellular logic of vertebrate neural development

Project Information

LogNeuroDev

Grant agreement ID: 742138

DOI 10.3030/742138

Project closed

EC signature date 4 December 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 357 000,00

EU contribution € 2 357 000,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Publications

Peer reviewed articles (12)

Tractable nonlinear memory functions as a tool to capture and explain dynamical behaviors

Author(s): Edgar Herrera-Delgado, James Briscoe, Peter Sollich
Published in: Physical Review Research, Issue 2/4, 2020, ISSN 2643-1564
Publisher: American Physical Society
DOI: 10.1103/physrevresearch.2.043069

Species-specific pace of development is associated with differences in protein stability

Author(s): Teresa Rayon; Despina Stamataki; Ruben Perez-Carrasco; Ruben Perez-Carrasco; Ruben Perez-Carrasco; Lorena Garcia-Perez; Christopher Barrington; Manuela Melchionda; Katherine Exelby; Jorge Lazaro; Victor L. J. Tybulewicz; Victor L. J. Tybulewicz; Elizabeth M. C. Fisher; James Briscoe
Published in: Science, Issue 1, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aba7667

A shared transcriptional code orchestrates temporal patterning of the central nervous system.

Author(s): Andreas Sagner; Andreas Sagner; Andreas Sagner; Isabel Zhang; Thomas Watson; Jorge Lazaro; Manuela Melchionda; James Briscoe
Published in: PLoS Biology, Issue 1, 2021, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001450

Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks.

Author(s): Katherine Exelby; Edgar Herrera-Delgado; Edgar Herrera-Delgado; Edgar Herrera-Delgado; Lorena Garcia Perez; Ruben Perez-Carrasco; Andreas Sagner; Andreas Sagner; Vicki Metzis; Vicki Metzis; Peter Sollich; Peter Sollich; James Briscoe
Published in: Development, Issue 1, 2019, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.197566

Looking at neurodevelopment through a big data lens

Author(s): James Briscoe, Oscar Marín
Published in: Science, Issue 369/6510, 2020, Page(s) eaaz8627, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz8627

Dynamical landscapes of cell fate decisions

Author(s): M. Sáez; J. Briscoe; D. A. Rand
Published in: 2042-8898, Issue 1, 2022, ISSN 2042-8898
Publisher: Royal Society Publishing
DOI: 10.1098/rsfs.2022.0002

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation

Author(s): Metzis V, Steinhauser S, Pakanavicius E, Gouti M, Stamataki D, Ivanovitch K, Watson T, Rayon T, Mousavy Gharavy SN, Lovell-Badge R, Luscombe NM, Briscoe J.
Published in: Cell, 2018, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.09.040

Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions.

Author(s): Meritxell Sáez; Meritxell Sáez; Robert Blassberg; Elena Camacho-Aguilar; Elena Camacho-Aguilar; Eric D. Siggia; David A. Rand; James Briscoe
Published in: Cell Systems, Issue 1, 2021, ISSN 2405-4712
Publisher: Cell Press
DOI: 10.1016/j.cels.2021.08.013

Establishing neuronal diversity in the spinal cord: a time and a place

Author(s): Andreas Sagner, James Briscoe
Published in: Development, Issue 146/22, 2019, Page(s) dev182154, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.182154

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

Author(s): Julien Delile, Teresa Rayon, Manuela Melchionda, Amelia Edwards, James Briscoe, Andreas Sagner
Published in: Development, Issue 146/12, 2019, Page(s) dev173807, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.173807

Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium

Author(s): Pilar Guerrero, Ruben Perez-Carrasco, Marcin Zagorski, David Page, Anna Kicheva, James Briscoe, Karen M. Page
Published in: Development, Issue 146/23, 2019, Page(s) dev176297, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.176297

Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies

Author(s): Delás MJ, Kalaitzis CM, Fawzi T, Demuth M, Zhang I, Stuart HT, Costantini E, Ivanovitch K, Tanaka EM, Briscoe J.
Published in: Developemental Cell, 2023, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.11.016

Other (3)

Neuronal differentiation affects tissue mechanics and progenitor arrangement in the vertebrate neuroepithelium

Author(s): Pilar Guerrero, Ruben Perez-Carrasco, Marcin Zagorski, David Page, Anna Kicheva, James Briscoe, Karen Page
Published in: BioRxiv, 2019
Publisher: BioRxiv
DOI: 10.1101/536342

Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks

Author(s): Katherine Exelby, Edgar Herrera-Delgado, Lorena Garcia Perez, Ruben Perez-Carrasco, Andreas Sagner, Vicki Metzis, Peter Sollich, James Briscoe
Published in: BioRxiv, 2019
Publisher: BioRxiv
DOI: 10.1101/721043

Species-specific developmental timing is associated with global differences in protein stability in mouse and human

Author(s): Teresa Rayon, Despina Stamataki, Ruben Perez-Carrasco, Lorena Garcia-Perez, Christopher Barrington, Manuela Melchionda, Katherine Exelby, Victor Tybulewicz, Elizabeth M. C. Fisher, James Briscoe
Published in: Biorxiv, 2019
Publisher: Biorxiv
DOI: 10.1101/2019.12.29.889543