Evolution of multicellularity and somatic cell specialization

Project Information

EVOSOM

Grant agreement ID: 742288

DOI 10.3030/742288

Project closed

EC signature date 26 April 2017

Start date 1 May 2017

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 128 602,00

EU contribution € 2 128 602,00

Coordinated by

UNIVERSITY OF DUNDEE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas

Author(s): Pauline Schaap
Published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Issue 376, 2021, Page(s) 20190756, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0756

Autophagy of the somatic stalk cells likely nurses the propagating spores of Dictyostelid social amoebas

Author(s): Qingyou Du, Pauline Schaap
Published in: Open Research Europe, Issue 2, 2022, Page(s) 104, ISSN 2732-5121
Publisher: F1000 Research Limited
DOI: 10.12688/openreseurope.14947.2

Loss of PIKfyve Causes Transdifferentiation of Dictyostelium Spores Into Basal Disc Cells

Author(s): Yoko Yamada, Gillian Forbes, Qingyou Du, Takefumi Kawata, Pauline Schaap
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, Page(s) 692473, ISSN 2296-634x
Publisher: Frontiers Media Limited
DOI: 10.3389/fcell.2021.692473

Development of the dictyostelid Polysphondylium violaceum doesnot require secreted cAMP

Author(s): Yoshinori Kawabe, Pauline Schaap
Published in: Biology Open, Issue 12, 2023, Page(s) bio059728, ISSN 2046-6390
Publisher: The Company of Biologists
DOI: 10.1242/bio.059728

Evolution of a novel cell type in Dictyostelia required gene duplication of a cudA-like transcription factor

Author(s): Koryu Kin, Zhi-hui Chen, Gillian Forbes, Pauline Schaap
Published in: Current Biology, Issue 32, 2022, Page(s) 428-437.e4, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.11.047

Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells

Author(s): Koryu Kin, Gillian Forbes, Andrew Cassidy, Pauline Schaap
Published in: BMC Genomics, Issue 19/1, 2018, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-018-5146-3

Multiple Roots of Fruiting Body Formation in Amoebozoa

Author(s): Falk Hillmann, Gillian Forbes, Silvia Novohradská, Iuliia Ferling, Konstantin Riege, Marco Groth, Martin Westermann, Manja Marz, Thomas Spaller, Thomas Winckler, Pauline Schaap, Gernot Glöckner
Published in: Genome Biology and Evolution, Issue 10/2, 2018, Page(s) 591-606, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evy011

Encystation: the most prevalent and underinvestigated differentiation pathway of eukaryotes

Author(s): Pauline Schaap, Christina Schilde
Published in: Microbiology, Issue 164/5, 2018, Page(s) 727-739, ISSN 1350-0872
Publisher: Society for General Microbiology
DOI: 10.1099/mic.0.000653

Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia

Author(s): Yoshinori Kawabe, Takahiro Morio, Yoshimasa Tanaka, Pauline Schaap
Published in: EvoDevo, Issue 9/1, 2018, ISSN 2041-9139
Publisher: BioMed Central
DOI: 10.1186/s13227-018-0101-6

Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas

Author(s): Gillian Forbes, Zhi-hui Chen, Koryu Kin, Hajara M. Lawal, Christina Schilde, Yoko Yamada, Pauline Schaap
Published in: BMC Genomics, Issue 20/1, 2019, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-019-6239-3

Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

Author(s): Samar Kabbara, Anaïs Hérivaux, Thomas Dugé de Bernonville, Vincent Courdavault, Marc Clastre, Amandine Gastebois, Marwan Osman, Monzer Hamze, J Mark Cock, Pauline Schaap, Nicolas Papon
Published in: Genome Biology and Evolution, Issue 11/1, 2018, Page(s) 86-108, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evy213

Evolution of multicellularity in Dictyostelia

Author(s): YOSHINORI KAWABE, QINGYOU DU, CHRISTINA SCHILDE and PAULINE SCHAAP
Published in: Int. J. Dev. Biol., Issue 63, 2019, Page(s) 359-369, ISSN 0214-6282
Publisher: University of the Basque Country Press
DOI: 10.1387/ijdb.190108ps

A well supported multi gene phylogeny of 52 dictyostelia

Author(s): Christina Schilde, Hajara M. Lawal, Koryu Kin, Ikumi Shibano-Hayakawa, Kei Inouye, Pauline Schaap
Published in: Molecular Phylogenetics and Evolution, Issue 134, 2019, Page(s) 66-73, ISSN 1055-7903
Publisher: Academic Press
DOI: 10.1016/j.ympev.2019.01.017

Loss of the Polyketide Synthase StlB Results in Stalk Cell Overproduction in Polysphondylium violaceum

Author(s): Takaaki B Narita, Yoshinori Kawabe, Koryu Kin, Richard A Gibbs, Adam Kuspa, Donna M Muzny, Stephen Richards, Joan E Strassmann, Richard Sucgang, Kim C Worley, Pauline Schaap
Published in: Genome Biology and Evolution, Issue 12/5, 2020, Page(s) 674-683, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evaa079

Cold climate adaptation is a plausible cause for evolution of multicellular sporulation in Dictyostelia

Author(s): Hajara M. Lawal, Christina Schilde, Koryu Kin, Matthew W. Brown, John James, Alan R. Prescott, Pauline Schaap
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 8797, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65709-3

Evolution of Multicellular Complexity in The Dictyostelid Social Amoebas

Author(s): Koryu Kin, Pauline Schaap
Published in: Genes, Issue 12, 2021, Page(s) 487, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12040487

Interactome and evolutionary conservation of Dictyostelid small GTPases and their direct regulators

Author(s): Gillian Forbes, Christina Schilde, Hajara Lawal, Koryu Kin, Qingyou Du, Zhi-hui Chen, Francisco Rivero, Pauline Schaap
Published in: Small GTPases, Issue 13, 2022, Page(s) 239-254, ISSN 2154-1248
Publisher: Landes Bioscience
DOI: 10.1080/21541248.2021.1984829

Novel RNAseq-Informed Cell-type Markers and Their Regulation Alter Paradigms of Dictyostelium Developmental Control

Author(s): Gillian Forbes, Zhi-Hui Chen, Koryu Kin, Pauline Schaap
Published in: Frontiers in Cell and Developmental Biology, Issue 10, 2022, Page(s) 899316, ISSN 2296-634x
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2022.899316

Adenylate cyclase A amplification and functional diversification during Polyspondylium pallidum development

Author(s): Yoshinori Kawabe, Pauline Schaap,
Published in: Evodevo, Issue 13, 2022, Page(s) 18, ISSN 2041-9139
Publisher: BioMed Central
DOI: 10.1186/s13227-022-00203-7

Phylogeny-wide analysis of G-protein coupled receptors in social amoebas and implications for the evolution of multicellularity

Author(s): Hall, G, Kelly, S, Schaap, P, Schilde, C,
Published in: Open Research Europe, Issue 2, 2023, Page(s) 134, ISSN 2732-5121
Publisher: F1000 Research Limite
DOI: 10.12688/openreseurope.15250.2

Abundantly expressed class of noncoding RNAs conserved through the multicellular evolution of dictyostelid social amoebae

Author(s): Kjellin, J. Avesson, L. Reimegård, J. Liao, Z. Eichinger, L. Noegel, A. Glöckner, G. Schaap, P. Söderbom, F.
Published in: Genome Research, Issue 31, 2021, Page(s) 436-447, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.272856.120

The protein kinases of Dictyostelia and their incorporation into a signalome

Author(s): Koryu Kin, Zhi-hui Chen, Gillian Forbes, Hajara Lawal, Christina Schilde, Reema Singh, Chris Cole, Geoffrey J. Barton, Pauline Schaap
Published in: Cellular Signaling, Issue 108, 2023, Page(s) 110714, ISSN 0898-6568
Publisher: Elsevier BV
DOI: 10.1016/j.cellsig.2023.110714

Book chapters (3)

Phylogenetic Distribution and a Case Study of Its Proximate and Ultimate Cause in Dictyostelia

Author(s): Pauline Schaap
Published in: The Evolution of Multicellularity, 2022, ISBN 9780429351907
Publisher: Taylor &Francis
DOI: 10.1201/9780429351907-7

Cyclic di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formation in Dictyostelium

Author(s): Zhi-hui Chen, Christina Schilde, Pauline Schaap
Published in: Microbial Cyclic Di-Nucleotide Signaling, 2020, Page(s) 563-574, ISBN 978-3-030-33308-9
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-33308-9_32

Resolving Amoebozoan Encystation from Dictyostelium Evo-Devo and Amoebozoan Comparative Genomics

Author(s): Qingyou Du, Yoshinori Kawabe, Pauline Schaap
Published in: Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology, 2020, Page(s) 19-29, ISBN 978-3-030-44826-4
Publisher: Springer
DOI: 10.1007/978-3-030-44826-4_2