Evolution of multicellularity and somatic cell specialization

Project Information

EVOSOM

Grant agreement ID: 742288

DOI 10.3030/742288

Project closed

EC signature date 26 April 2017

Start date 1 May 2017

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 128 602,00

EU contribution € 2 128 602,00

Coordinated by

UNIVERSITY OF DUNDEE
United Kingdom

Publications

Peer reviewed articles (22)

From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas

Author(s): Pauline Schaap
Published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Issue 376, 2021, Page(s) 20190756, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0756

Autophagy of the somatic stalk cells likely nurses the propagating spores of Dictyostelid social amoebas

Author(s): Qingyou Du, Pauline Schaap
Published in: Open Research Europe, Issue 2, 2022, Page(s) 104, ISSN 2732-5121
Publisher: F1000 Research Limited
DOI: 10.12688/openreseurope.14947.2

Loss of PIKfyve Causes Transdifferentiation of Dictyostelium Spores Into Basal Disc Cells

Author(s): Yoko Yamada, Gillian Forbes, Qingyou Du, Takefumi Kawata, Pauline Schaap
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, Page(s) 692473, ISSN 2296-634x
Publisher: Frontiers Media Limited
DOI: 10.3389/fcell.2021.692473

Development of the dictyostelid Polysphondylium violaceum doesnot require secreted cAMP

Author(s): Yoshinori Kawabe, Pauline Schaap
Published in: Biology Open, Issue 12, 2023, Page(s) bio059728, ISSN 2046-6390
Publisher: The Company of Biologists
DOI: 10.1242/bio.059728

Evolution of a novel cell type in Dictyostelia required gene duplication of a cudA-like transcription factor

Author(s): Koryu Kin, Zhi-hui Chen, Gillian Forbes, Pauline Schaap
Published in: Current Biology, Issue 32, 2022, Page(s) 428-437.e4, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.11.047

Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells

Author(s): Koryu Kin, Gillian Forbes, Andrew Cassidy, Pauline Schaap
Published in: BMC Genomics, Issue 19/1, 2018, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-018-5146-3

Multiple Roots of Fruiting Body Formation in Amoebozoa

Author(s): Falk Hillmann, Gillian Forbes, Silvia Novohradská, Iuliia Ferling, Konstantin Riege, Marco Groth, Martin Westermann, Manja Marz, Thomas Spaller, Thomas Winckler, Pauline Schaap, Gernot Glöckner
Published in: Genome Biology and Evolution, Issue 10/2, 2018, Page(s) 591-606, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evy011

Encystation: the most prevalent and underinvestigated differentiation pathway of eukaryotes

Author(s): Pauline Schaap, Christina Schilde
Published in: Microbiology, Issue 164/5, 2018, Page(s) 727-739, ISSN 1350-0872
Publisher: Society for General Microbiology
DOI: 10.1099/mic.0.000653

Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia

Author(s): Yoshinori Kawabe, Takahiro Morio, Yoshimasa Tanaka, Pauline Schaap
Published in: EvoDevo, Issue 9/1, 2018, ISSN 2041-9139
Publisher: BioMed Central
DOI: 10.1186/s13227-018-0101-6

Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas

Author(s): Gillian Forbes, Zhi-hui Chen, Koryu Kin, Hajara M. Lawal, Christina Schilde, Yoko Yamada, Pauline Schaap
Published in: BMC Genomics, Issue 20/1, 2019, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-019-6239-3

Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

Author(s): Samar Kabbara, Anaïs Hérivaux, Thomas Dugé de Bernonville, Vincent Courdavault, Marc Clastre, Amandine Gastebois, Marwan Osman, Monzer Hamze, J Mark Cock, Pauline Schaap, Nicolas Papon
Published in: Genome Biology and Evolution, Issue 11/1, 2018, Page(s) 86-108, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evy213

Evolution of multicellularity in Dictyostelia

Author(s): YOSHINORI KAWABE, QINGYOU DU, CHRISTINA SCHILDE and PAULINE SCHAAP
Published in: Int. J. Dev. Biol., Issue 63, 2019, Page(s) 359-369, ISSN 0214-6282
Publisher: University of the Basque Country Press
DOI: 10.1387/ijdb.190108ps

A well supported multi gene phylogeny of 52 dictyostelia

Author(s): Christina Schilde, Hajara M. Lawal, Koryu Kin, Ikumi Shibano-Hayakawa, Kei Inouye, Pauline Schaap
Published in: Molecular Phylogenetics and Evolution, Issue 134, 2019, Page(s) 66-73, ISSN 1055-7903
Publisher: Academic Press
DOI: 10.1016/j.ympev.2019.01.017

Loss of the Polyketide Synthase StlB Results in Stalk Cell Overproduction in Polysphondylium violaceum

Author(s): Takaaki B Narita, Yoshinori Kawabe, Koryu Kin, Richard A Gibbs, Adam Kuspa, Donna M Muzny, Stephen Richards, Joan E Strassmann, Richard Sucgang, Kim C Worley, Pauline Schaap
Published in: Genome Biology and Evolution, Issue 12/5, 2020, Page(s) 674-683, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evaa079

Cold climate adaptation is a plausible cause for evolution of multicellular sporulation in Dictyostelia

Author(s): Hajara M. Lawal, Christina Schilde, Koryu Kin, Matthew W. Brown, John James, Alan R. Prescott, Pauline Schaap
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 8797, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65709-3

Evolution of Multicellular Complexity in The Dictyostelid Social Amoebas

Author(s): Koryu Kin, Pauline Schaap
Published in: Genes, Issue 12, 2021, Page(s) 487, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12040487

Interactome and evolutionary conservation of Dictyostelid small GTPases and their direct regulators

Author(s): Gillian Forbes, Christina Schilde, Hajara Lawal, Koryu Kin, Qingyou Du, Zhi-hui Chen, Francisco Rivero, Pauline Schaap
Published in: Small GTPases, Issue 13, 2022, Page(s) 239-254, ISSN 2154-1248
Publisher: Landes Bioscience
DOI: 10.1080/21541248.2021.1984829

Novel RNAseq-Informed Cell-type Markers and Their Regulation Alter Paradigms of Dictyostelium Developmental Control

Author(s): Gillian Forbes, Zhi-Hui Chen, Koryu Kin, Pauline Schaap
Published in: Frontiers in Cell and Developmental Biology, Issue 10, 2022, Page(s) 899316, ISSN 2296-634x
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2022.899316

Adenylate cyclase A amplification and functional diversification during Polyspondylium pallidum development

Author(s): Yoshinori Kawabe, Pauline Schaap,
Published in: Evodevo, Issue 13, 2022, Page(s) 18, ISSN 2041-9139
Publisher: BioMed Central
DOI: 10.1186/s13227-022-00203-7

Phylogeny-wide analysis of G-protein coupled receptors in social amoebas and implications for the evolution of multicellularity

Author(s): Hall, G, Kelly, S, Schaap, P, Schilde, C,
Published in: Open Research Europe, Issue 2, 2023, Page(s) 134, ISSN 2732-5121
Publisher: F1000 Research Limite
DOI: 10.12688/openreseurope.15250.2

Abundantly expressed class of noncoding RNAs conserved through the multicellular evolution of dictyostelid social amoebae

Author(s): Kjellin, J. Avesson, L. Reimegård, J. Liao, Z. Eichinger, L. Noegel, A. Glöckner, G. Schaap, P. Söderbom, F.
Published in: Genome Research, Issue 31, 2021, Page(s) 436-447, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.272856.120

The protein kinases of Dictyostelia and their incorporation into a signalome

Author(s): Koryu Kin, Zhi-hui Chen, Gillian Forbes, Hajara Lawal, Christina Schilde, Reema Singh, Chris Cole, Geoffrey J. Barton, Pauline Schaap
Published in: Cellular Signaling, Issue 108, 2023, Page(s) 110714, ISSN 0898-6568
Publisher: Elsevier BV
DOI: 10.1016/j.cellsig.2023.110714

Book chapters (3)

Phylogenetic Distribution and a Case Study of Its Proximate and Ultimate Cause in Dictyostelia

Author(s): Pauline Schaap
Published in: The Evolution of Multicellularity, 2022, ISBN 9780429351907
Publisher: Taylor &Francis
DOI: 10.1201/9780429351907-7

Cyclic di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formation in Dictyostelium

Author(s): Zhi-hui Chen, Christina Schilde, Pauline Schaap
Published in: Microbial Cyclic Di-Nucleotide Signaling, 2020, Page(s) 563-574, ISBN 978-3-030-33308-9
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-33308-9_32

Resolving Amoebozoan Encystation from Dictyostelium Evo-Devo and Amoebozoan Comparative Genomics

Author(s): Qingyou Du, Yoshinori Kawabe, Pauline Schaap
Published in: Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology, 2020, Page(s) 19-29, ISBN 978-3-030-44826-4
Publisher: Springer
DOI: 10.1007/978-3-030-44826-4_2