Spatiotemporal organisation of bacterial outer membrane proteins

Project Information

OMPorg

Grant agreement ID: 742555

DOI

10.3030/742555

Project closed

EC signature date 21 April 2017

Start date 1 September 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 235 815,00

EU contribution

€ 2 235 815,00

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

The multifarious roles of Tol-Pal in Gram-negative bacteria

Author(s): Joanna Szczepaniak; Cara Press; Colin Kleanthous
Published in: FEMS Microbiology Reviews, Issue 1, 2020, ISSN 0168-6445
Publisher: Blackwell
DOI: 10.1093/femsre/fuaa018

Tunable force transduction through the <i>Escherichia coli</i> cell envelope

Author(s): Daniel P. Williams-Jones, Melissa N. Webby, Cara E. Press, Jan M. Gradon, Sophie R. Armstrong, Joanna Szczepaniak, Colin Kleanthous
Published in: Proceedings of the National Academy of Sciences, Issue 120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2306707120

Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF.

Author(s): Marie-Louise R. Francis; Melissa N. Webby; Nicholas G. Housden; Renata Kaminska; Emma Elliston; Boonyaporn Chinthammit; Natalya Lukoyanova; Colin Kleanthous
Published in: The EMBO Journal, Issue 1, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108610

Phase separation in the outer membrane of Escherichia coli

Author(s): Benn, G., Mikheyeva, I.V., Inns, P.G., Forster, J.C., Ojkic, N., Bortolini, C., Ryadnov, M.G., Kleanthous, C., Silhavy, T.J. & Hoogenboom, B.W.
Published in: Proceedings of the National Academy of Sciences USA, 2021, Page(s) e2112237118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2112237118

The quantitative basis for the redistribution of immobile bacterial lipoproteins to division septa.

Author(s): Lara Connolley; Sean Murray; Joanna Szczepaniak; Colin Kleanthous
Published in: PLoS Computational Biology, Issue 1, 2021, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1009756

Tools and Approaches for Dissecting Protein Bacteriocin Import in Gram-Negative Bacteria

Author(s): Iva Atanaskovic; Colin Kleanthous
Published in: Frontiers in Microbiology, Vol 10 (2019), Issue 1, 2019, ISSN 1664-302X
Publisher: Frontiers Media

Force generation by the trans-envelope Tol-Pal system

Author(s): Webby, M. N., Williams-Jones, D.P., Press, C. & Kleanthous, C
Published in: Frontiers in Microbiology, Issue 13, 2022, Page(s) 852176, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2022.852176

Toxin import through the antibiotic efflux channel TolC

Author(s): Housden, N.G., Webby, M.N., Lowe, E.D., El-Baba, T.J., Kaminska, R., Redfield, C., Robinson, C.V. & Kleanthous, C
Published in: Nature Communications, Issue 12, 2021, Page(s) 4625, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24930-y

Intermembrane crosstalk drives inner-membrane protein organization in Escherichia coli

Author(s): Patrice Rassam, Kathleen R. Long, Renata Kaminska, David J. Williams, Grigorios Papadakos, Christoph G. Baumann, Colin Kleanthous
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03521-4

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Author(s): Matthieu Chavent, Anna L. Duncan, Patrice Rassam, Oliver Birkholz, Jean Hélie, Tyler Reddy, Dmitry Beliaev, Ben Hambly, Jacob Piehler, Colin Kleanthous, Mark S. P. Sansom
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05255-9

O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli

Author(s): Connor Sharp, Christine Boinett, Amy Cain, Nicholas G. Housden, Sandip Kumar, Keith Turner, Julian Parkhill, Colin Kleanthous
Published in: Journal of Bacteriology, Issue 201/4, 2019, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/jb.00545-18

The lipoprotein Pal stabilises the bacterial outer membrane during constriction by a mobilisation-and-capture mechanism

Author(s): Joanna Szczepaniak, Peter Holmes, Karthik Rajasekar, Renata Kaminska, Firdaus Samsudin, Patrick George Inns, Patrice Rassam, Syma Khalid, Seán M. Murray, Christina Redfield, Colin Kleanthous
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15083-5

Antibiotics and hexagonal order in the bacterial outer membrane

Author(s): Benn, G., Silhavy, T.J., Kleanthous, C. & Hoogenboom, B.W.
Published in: Nature Communications, Issue 14, 2023, Page(s) 4772, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40275-0

Peptidoglycan maturation controls spatiotemporal organisation of outer membrane proteins in Escherichia coli

Author(s): Mamou, G., Corona, F., Cohen-Khait, R., Housden, N.G., Yeung, V., Sun, D., Sridhar, P., Knowles, T.J., Kleanthous, C. & Vollmer, W.
Published in: Nature, Issue 606, 2022, Page(s) 953-959, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04834-7

Bifurcated binding of the OmpF receptor underpins import of the bacteriocin colicin N into Escherichia coli

Author(s): Jansen, K.B., Inns, P.G., Housden, N.G., Hopper, J.T.S., Kaminska, R., Lee, S., Robinson, C.V., Bayley, H. & Kleanthous, C
Published in: Journal of Biological Chemistry, Issue 295, 2020, Page(s) 9147-9156, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.013508

Lipids mediate supramolecular outer membrane protein assembly in bacteria

Author(s): Webby, M.N., Oluwole, A.O., Pedebos, C., Inns, P.G., Olerinyova, A., Prakaash, D., Housden, N.G., Benn, G., Sun, D., Hoogenboom, B.W., Kukura, P., Mohammed, S., Robinson, C.V., Khalid, S. & Kleanthous, C
Published in: Science Advances, Issue 8, 2022, Page(s) eadc9566, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adc9566