Self-organisation across the scales in early mammalian development

Project Information

SelforganisingEmbryo

Grant agreement ID: 742732

DOI 10.3030/742732

Project closed

EC signature date 29 August 2017

Start date 1 September 2017

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 239 458,00

EU contribution € 2 239 458,00

Coordinated by

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands

Publications

Peer reviewed articles (9)

Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis

Author(s): Qiutan Yang, Shi-Lei Xue, Chii Jou Chan, Markus Rempfler, Dario Vischi, Francisca Mauer Gutierrez, Takashi Hiiragi, Edouard Hannezo, Prisca Liberali
Published in: Nature Cell Biology, Issue 23/2021, 2021, Page(s) 733-744, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1101/2020.05.13.094359

ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo

Author(s): Kim, E. J. Y., Sorokin, L. and Hiiragi, T.
Published in: Development, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.200140

Inferring cell junction tension and pressure from cell geometry

Author(s): Chloé Roffay, Chii J. Chan, Boris Guirao, Takashi Hiiragi, François Graner
Published in: Development, Issue 148/18, 2021, Page(s) dev192773, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.192773

Muscular hydraulics drive larva-polyp morphogenesis

Author(s): Anniek Stokkermans, Aditi Chakrabarti, Kaushikaram Subramanian , Ling Wang, Sifan Yin, Prachiti Moghe, Petrus Steenbergen, Gregor Mönke, Takashi Hiiragi, Robert Prevedel, L. Mahadevan, Aissam Ikmi.
Published in: Current Biology, Issue 32/21, 2022, Page(s) 4707-4718.e8, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.08.065

An ex vivo system to study cellular dynamics underlying mouse peri-implantation development

Author(s): Ichikawa, T., Zhang, H. T., Panavaite, L., Erzberger, A., Fabrèges, D., Snajder, R., Wolny, A., Korotkevich, E., Tsuchida-Straeten, N., Hufnagel, L., Kreshuk, A. and Hiiragi, T.
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.12.023

Integration of luminal pressure and signalling in tissue self-organization

Author(s): Chii J. Chan, Takashi Hiiragi
Published in: Development, Issue 147/5, 2020, Page(s) dev181297, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.181297

A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst

Author(s): Ritsuya Niwayama, Prachiti Moghe, Yan-Jun Liu, Dimitri Fabrèges, Frank Buchholz, Matthieu Piel, Takashi Hiiragi
Published in: Developmental Cell, Issue 51/5, 2019, Page(s) 564-574.e6, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.10.012

Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation

Author(s): Allyson Quinn Ryan, Chii Jou Chan, François Graner, Takashi Hiiragi
Published in: Developmental Cell, Issue 51/6, 2019, Page(s) 684-697.e4, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.10.011

Hydraulic control of mammalian embryo size and cell fate

Author(s): Chii Jou Chan, Maria Costanzo, Teresa Ruiz-Herrero, Gregor Mönke, Ryan J. Petrie, Martin Bergert, Alba Diz-Muñoz, L. Mahadevan, Takashi Hiiragi
Published in: Nature, Issue 571/7763, 2019, Page(s) 112-116, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1309-x

Other (3)

Coordination Between Embryo Growth and Trophoblast Migration Upon Implantation Delineates Mouse Embryogenesis

Author(s): Bondarenko V., Nikolaev M., Kromm D., Belousov R., Wolny A., Rezakhani S., Hugger J., Uhlmann V., Hufnagel L., Kreshuk A., Ellenberg J., Erzberger A., Lutolf M., Hiiragi T.
Published in: bioRxiv, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.06.13.495767

Apical-driven cell sorting optimised for tissue geometry ensures robust patterning

Author(s): Prachiti Moghe, Roman Belousov, Takafumi Ichikawa, Chizuru Iwatani, Tomoyuki Tsukiyama, François Graner, Anna Erzberger, Takashi Hiiragi.
Published in: bioRxiv, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.16.540918

Temporal variability and cell mechanics control robustness in mammalian embryogenesis

Author(s): Dimitri Fabrèges, Bernat Corominas Murtra, Prachiti Moghe, Alison Kickuth, Takafumi Ichikawa, Chizuru Iwatani, Tomoyuki Tsukiyama, Nathalie Daniel, Julie Gering, Anniek Stokkermans, Adrian Wolny, Anna Kreshuk, Véronique Duranthon, Virginie Uhlmann, Edouard Hannezo, Takashi Hiiragi.
Published in: bioRxiv, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.24.525420