Inherited disfunctions of brain microcirculation

Project Information

V-EPC

Grant agreement ID: 742922

DOI 10.3030/742922

Project closed

EC signature date 11 August 2017

Start date 1 September 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 451 250,00

EU contribution € 2 451 250,00

Coordinated by

IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Italy

Publications

Peer reviewed articles (17)

Histological quantification of cerebral cavernous malformations in the murine brain

Author(s): Claudio Maderna , Elisabetta Dejana, Matteo Malinverno
Published in: STAR Protoc, 2022, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2022.101448

Inflammation and neutrophil extracellular traps in cerebral cavernous malformation

Author(s): Yau ACY, Globisch MA, Onyeogaziri FC, Conze LL, Smith R, Jauhiainen S, Corada M, Orsenigo F, Huang H, Herre M, Olsson AK, Malinverno M, Sundell V, Rezai Jahromi B, Niemelä M, Laakso A, Garlanda C, Mantovani A, Lampugnani MG, Dejana E, Magnusson PU
Published in: Cell Mol Life Sci, 2022, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04224-2

A murine model of cerebral cavernous malformations with acute hemorrhage

Author(s): Maderna C, Pisati F, Tripodo C, Dejana E, Malinverno M
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2022.103943

Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

Author(s): Orsenigo F, Conze LL, Jauhiainen S, Corada M, Lazzaroni F, Malinverno M, Sundell V, Cunha SI, Brännström J, Globisch MA, Maderna C, Lampugnani MG, Magnusson PU, Dejana E
Published in: eLife, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61413

Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation

Author(s): Maria A. Globisch, Favour C. Onyeogaziri, Suvi Jauhiainen, Anthony C. Y. Yau, Fabrizio Orsenigo, Lei L. Conze, Maximiliano Arce, Monica Corada, Ross O. Smith, Charlotte Rorsman, Veronica Sundell, Dinesh Fernando, Geoffrey Daniel, Oscar Mattsson, Henri Savander, Alkwin Wanders, Behnam Rezai Jahromi, Aki Laakso, Mika Niemelä, Elisabetta Dejana, Peetra U. Magnusson
Published in: Blood, 2022, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2021015350

A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition

Author(s): Savorani C, Malinverno M, Seccia R, Maderna C, Giannotta M, Terreran L, Mastrapasqua E, Campaner S, Dejana E, Giampietro C
Published in: J Cell Sci, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.251371

JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function.

Author(s): Nikolaos Kakogiannos; Laura Ferrari; Costanza Giampietro; Anna Agata Scalise; Claudio Maderna; Micol Ravà; Andrea Taddei; Maria Grazia Lampugnani; Federica Pisati; Matteo Malinverno; Emanuele Martini; Ilaria Costa; Michela Lupia; Ugo Cavallaro; Galina V. Beznoussenko; Alexander A. Mironov; Bethania Fernandes; Noemi Rudini; Elisabetta Dejana; Elisabetta Dejana; Monica Giannotta
Published in: Circulation Research, Issue 3, 2020, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316742

Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.

Author(s): Azzurra Cottarelli; Monica Corada; Galina V. Beznoussenko; Alexander A. Mironov; Maria Ascención Globisch; Saptarshi Biswas; Hua Huang; Anna Dimberg; Peetra U. Magnusson; Dritan Agalliu; Maria Grazia Lampugnani; Elisabetta Dejana; Elisabetta Dejana
Published in: Development, Issue 1, 2020, ISSN 1011-6370
Publisher: Palgrave Macmillan Ltd.
DOI: 10.1242/dev.185140

The multifaceted PDCD10/CCM3 gene

Author(s): Valentino M, Dejana E, Malinverno M
Published in: Genes Dis, 2020, ISSN 2352-3042
Publisher: Elsevier
DOI: 10.1016/j.gendis.2020.12.008

Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations: A Preclinical Study

Author(s): Oldenburg J, Malinverno M, Globisch MA, Maderna C, Corada M, Orsenigo F, Conze LL, Rorsman C, Sundell V, Arce M, Smith RO, Yau ACY, Billström GH, Mägi CÖ, Beznoussenko GV, Mironov AA, Fernando D, Daniel G, Olivari D, Fumagalli F, Lampugnani MG, Dejana E, Magnusson PU
Published in: Stroke, 2021, ISSN 0039-2499
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.029676

Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier

Author(s): Monica Corada, Fabrizio Orsenigo, Ganesh Parameshwar Bhat, Lei Liu Conze, Ferruccio Breviario, Sara Isabel Cunha, Lena Claesson-Welsh, Galina V. Beznoussenko, Alexander A. Mironov, Marco Bacigaluppi, Gianvito Martino, Mara E. Pitulescu, Ralf H. Adams, Peetra Magnusson, Elisabetta Dejana
Published in: Circulation Research, Issue 124/4, 2019, Page(s) 511-525, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.313316

Deregulated TGF-β/BMP Signaling in Vascular Malformations

Author(s): Sara I. Cunha, Peetra U. Magnusson, Elisabetta Dejana, Maria Grazia Lampugnani
Published in: Circulation Research, Issue 121/8, 2017, Page(s) 981-999, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.309930

VE-Cadherin–Mediated Epigenetic Regulation of Endothelial Gene Expression

Author(s): Marco F. Morini, Costanza Giampietro, Monica Corada, Federica Pisati, Elisa Lavarone, Sara I. Cunha, Lei L. Conze, Nicola O’Reilly, Dhira Joshi, Svend Kjaer, Roger George, Emma Nye, Anqi Ma, Jian Jin, Richard Mitter, Michela Lupia, Ugo Cavallaro, Diego Pasini, Dinis P. Calado, Elisabetta Dejana, Andrea Taddei
Published in: Circulation Research, Issue 122/2, 2018, Page(s) 231-245, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.312392

Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression

Author(s): Agnieszka Martowicz, Marta Trusohamn, Nina Jensen, Joanna Wisniewska-Kruk, Monica Corada, Frank Chenfei Ning, Julianna Kele, Elisabetta Dejana, Daniel Nyqvist
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 39/11, 2019, Page(s) 2273-2288, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.119.312749

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Author(s): Matteo Malinverno, Claudio Maderna, Abdallah Abu Taha, Monica Corada, Fabrizio Orsenigo, Mariaelena Valentino, Federica Pisati, Carmela Fusco, Paolo Graziano, Monica Giannotta, Qing Cissy Yu, Yi Arial Zeng, Maria Grazia Lampugnani, Peetra U. Magnusson, Elisabetta Dejana
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10707-x

CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression

Author(s): Marco Castro, Bàrbara Laviña, Koji Ando, Alberto Álvarez-Aznar, Abdallah Abu Taha, Cord Brakebusch, Elisabetta Dejana, Christer Betsholtz, Konstantin Gaengel
Published in: Circulation Research, Issue 124/8, 2019, Page(s) 1240-1252, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.314300

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

Author(s): Claesson-Welsh L, Dejana E, McDonald DM
Published in: Trends Mol Med, 2021, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2020.11.006