Lubricating Cartilage: exploring the relation between lubrication and gene-regulation to alleviate osteoarthritis

Project Information

CartiLube

Grant agreement ID: 743016

DOI 10.3030/743016

Project closed

EC signature date 19 July 2017

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 944,00

EU contribution € 2 499 944,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publications

Peer reviewed articles (28)

Dehydration does not affect lipid-based hydrationlubrication

Author(s): Yihui Dong, Nir Kampf, Yaelle Schilt, Wei Cao, Uri Raviv and Jacob Klein
Published in: Nanoscale, 2022, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr04799c

Lipids and lipid-mixtures in boundary layers: from hydration lubrication to osteoarthritis

Author(s): Y. Cao, J. Klein
Published in: Current Opinions in Colloid and Interface Science, 2022, ISSN 1359-0294
Publisher: Pergamon Press
DOI: 10.1016/j.cocis.2021.101559

Direct measurement of surface forces: Recent advances and insights

Author(s): W. Lin, J. Klein
Published in: Applied Physics Reviews, 2021, ISSN 1931-9401
Publisher: AIP Publishing LLC
DOI: 10.1063/5.0059893

Modulating Interfacial Energy Dissipation via Potential-Controlled Ion Trapping

Author(s): R. Tivony, Y. Zhang, J. Klein
Published in: J. Phys. Chem.C, 2020, ISSN 1932-7447
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.0c11264

Designer Nanoparticles as Robust Superlubrication Vectors

Author(s): Weifeng Lin, Nir Kampf, Jacob Klein
Published in: ACS Nano, Issue 14/6, 2020, Page(s) 7008-7017, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c01559

Direct measurement of the viscoelectric effect in water

Author(s): Jin, D., Hwang, Y., Nir Kampf , N. and Klein, J.
Published in: Proceeding of the National Academy of Science (PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2113690119

Effect of cholesterol on the mechanical stability of gel-phase phospholipid bilayers studied by AFM force spectroscopy

Author(s): Salomé Mielke , Raya Sorkin , Jacob Klein
Published in: EPJ E, 2023, ISSN 1292-8941
Publisher: Springer Verlag
DOI: 10.1140/epje/s10189-023-00338-y

Neutral polyphosphocholine-modified liposomes as boundary superlubricants

Author(s): Weifeng Lin, Nir Kampf, Jacob Klein
Published in: Colloids and Surfaces A, 2022, ISSN 1873-4359
Publisher: Elsevier
DOI: 10.1016/j.colsurfa.2022.129218

Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice

Author(s): Clarissa R. Coveney, Linyi Zhu, Jadwiga Miotla-Zarebska, Bryony Stott, Ida Parisi, Vicky Batchelor, Claudia Duarte, Emer Chang, Eleanor McSorley, Tonia L. Vincent, Angus K. T. Wann
Published in: Arthritis and Rheumatology, 2021, ISSN 2326-5191
Publisher: American College of Rheumatology
DOI: 10.1002/art.41894

Lipid-Bilayer Assemblies on Polymer-Bearing Surfaces: The Nature of the Slip Plane in Asymmetric Boundary Lubrication: The Nature of the Slip Plane in Asymmetric Boundary

Author(s): S.A. Angayarkani, N. Kampf, J. Klein
Published in: Langmuir, 2020, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.0c02956

Designer Liposomic Nanocarriers Are Effective Biofilm Eradicators

Author(s): Monika Kluzek, Yaara Oppenheimer-Shaanan, Tali Dadosh, Mattia I. Morandi, Ori Avinoam, Calanit Raanan, Moshe Goldsmith, Ronit Goldberg, and Jacob Klein
Published in: ACS Nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c04232

Poly-phosphocholination of liposomes leads to highly-extended retention time in mice joints

Author(s): W. Lin, R. Goldberg, J. Klein
Published in: J. Materials Chemistry - B, 2022, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tb02346b

The Role of Hyaluronic Acid in Cartilage Boundary Lubrication

Author(s): Weifeng Lin, Zhang Liu, Nir Kampf, Jacob Klein
Published in: Cells, Issue 9/7, 2020, Page(s) 1606, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9071606

Lubrication of articular cartilage

Author(s): Sabrina Jahn, Jacob Klein
Published in: Physics Today, Issue 71/4, 2018, Page(s) 48-54, ISSN 0031-9228
Publisher: American Institute of Physics
DOI: 10.1063/pt.3.3898

Charging dynamics of an individual nanopore

Author(s): Ran Tivony, Sam Safran, Philip Pincus, Gilad Silbert, Jacob Klein
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06364-1

Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction

Author(s): Weifeng Lin, Reut Mashiah, Jasmine Seror, Assaf Kadar, Oleg Dolkart, Tamir Pritsch, Ronit Goldberg, Jacob Klein
Published in: Acta Biomaterialia, Issue 83, 2019, Page(s) 314-321, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.11.015

Trapped Aqueous Films Lubricate Highly Hydrophobic Surfaces

Author(s): Irit Rosenhek-Goldian, Nir Kampf, Jacob Klein
Published in: ACS Nano, Issue 12/10, 2018, Page(s) 10075-10083, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b04735

Control of surface forces through hydrated boundary layers

Author(s): Weifeng Lin, Jacob Klein
Published in: Current Opinion in Colloid & Interface Science, Issue 44, 2019, Page(s) 94-106, ISSN 1359-0294
Publisher: Pergamon Press
DOI: 10.1016/j.cocis.2019.10.001

Normal and shear forces between boundary sphingomyelin layers under aqueous conditions

Author(s): Yifeng Cao, Nir Kampf, Weifeng Lin, Jacob Klein
Published in: Soft Matter, 2020, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm00215a

Surface Interactions between Boundary Layers of Poly(ethylene oxide)–Liposome Complexes: Lubrication, Bridging, and Selective Ligation

Author(s): S. A. Angayarkanni, Nir Kampf, Jacob Klein
Published in: Langmuir, Issue 35/48, 2019, Page(s) 15469-15480, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01708

Origins of the long-ranged attraction between surfaces that were rendered hydrophobic by surfactant layers

Author(s): Jacob Klein
Published in: Advances in Colloid and Interface Science, Issue 270, 2019, Page(s) 261-262, ISSN 0001-8686
Publisher: Elsevier BV
DOI: 10.1016/j.cis.2019.06.009

Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors

Author(s): Weifeng Lin, Nir Kampf, Ronit Goldberg, Michael J. Driver, Jacob Klein
Published in: Langmuir, Issue 35/18, 2019, Page(s) 6048-6054, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b00610

Boundary Lubrication, Hemifusion, and Self-Healing of Binary Saturated and Monounsaturated Phosphatidylcholine Mixtures

Author(s): Yifeng Cao, Nir Kampf, Jacob Klein
Published in: Langmuir, Issue 35/48, 2019, Page(s) 15459-15468, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01660

Recent Progress in Cartilage Lubrication

Author(s): Weifeng Lin, Jacob Klein
Published in: Advanced Materials, 2021, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202005513

Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels

Author(s): Weifeng Lin, jacob Klein
Published in: Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels, 2022, ISSN 2643-6728
Publisher: American Chemical Society
DOI: 10.1021/accountsmr.1c00219

Effects of Hyaluronan Molecular Weight on the Lubrication of Cartilage-Emulating Boundary Layers

Author(s): Zhang Liu, Weifeng Lin, Yaxun Fan, Nir Kampf, Yilin Wang, Jacob Klein
Published in: Biomacromolecules, Issue 21/10, 2020, Page(s) 4345-4354, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c01151

Interactions Between Bilayers of Phospholipids Extracted from Human Osteoarthritic Synovial Fluid

Author(s): Yifeng Cao, Nir Kampf, Marta Krystyna Kosinska, Juergen Steinmeyer, Jacob Klein
Published in: Biotribology, 2021, ISSN 2352-5738
Publisher: Elsevier
DOI: 10.1016/j.biotri.2020.100157

Cartilage inspired, lipid-based boundary lubricated hydrogels

Author(s): Lin, W-F, Kluzek, M., Iuster, N., Shimoni, E., Kampf, N., Goldberg, R., Klein, J.
Published in: Science, Issue Weekly, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay8276