Lubricating Cartilage: exploring the relation between lubrication and gene-regulation to alleviate osteoarthritis

Project Information

CartiLube

Grant agreement ID: 743016

DOI

10.3030/743016

Project closed

EC signature date 19 July 2017

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 944,00

EU contribution

€ 2 499 944,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (28)

Dehydration does not affect lipid-based hydrationlubrication

Author(s): Yihui Dong, Nir Kampf, Yaelle Schilt, Wei Cao, Uri Raviv and Jacob Klein
Published in: Nanoscale, 2022, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr04799c

Lipids and lipid-mixtures in boundary layers: from hydration lubrication to osteoarthritis

Author(s): Y. Cao, J. Klein
Published in: Current Opinions in Colloid and Interface Science, 2022, ISSN 1359-0294
Publisher: Pergamon Press
DOI: 10.1016/j.cocis.2021.101559

Direct measurement of surface forces: Recent advances and insights

Author(s): W. Lin, J. Klein
Published in: Applied Physics Reviews, 2021, ISSN 1931-9401
Publisher: AIP Publishing LLC
DOI: 10.1063/5.0059893

Modulating Interfacial Energy Dissipation via Potential-Controlled Ion Trapping

Author(s): R. Tivony, Y. Zhang, J. Klein
Published in: J. Phys. Chem.C, 2020, ISSN 1932-7447
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.0c11264

Designer Nanoparticles as Robust Superlubrication Vectors

Author(s): Weifeng Lin, Nir Kampf, Jacob Klein
Published in: ACS Nano, Issue 14/6, 2020, Page(s) 7008-7017, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c01559

Direct measurement of the viscoelectric effect in water

Author(s): Jin, D., Hwang, Y., Nir Kampf , N. and Klein, J.
Published in: Proceeding of the National Academy of Science (PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2113690119

Effect of cholesterol on the mechanical stability of gel-phase phospholipid bilayers studied by AFM force spectroscopy

Author(s): Salomé Mielke , Raya Sorkin , Jacob Klein
Published in: EPJ E, 2023, ISSN 1292-8941
Publisher: Springer Verlag
DOI: 10.1140/epje/s10189-023-00338-y

Neutral polyphosphocholine-modified liposomes as boundary superlubricants

Author(s): Weifeng Lin, Nir Kampf, Jacob Klein
Published in: Colloids and Surfaces A, 2022, ISSN 1873-4359
Publisher: Elsevier
DOI: 10.1016/j.colsurfa.2022.129218

Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice

Author(s): Clarissa R. Coveney, Linyi Zhu, Jadwiga Miotla-Zarebska, Bryony Stott, Ida Parisi, Vicky Batchelor, Claudia Duarte, Emer Chang, Eleanor McSorley, Tonia L. Vincent, Angus K. T. Wann
Published in: Arthritis and Rheumatology, 2021, ISSN 2326-5191
Publisher: American College of Rheumatology
DOI: 10.1002/art.41894

Lipid-Bilayer Assemblies on Polymer-Bearing Surfaces: The Nature of the Slip Plane in Asymmetric Boundary Lubrication: The Nature of the Slip Plane in Asymmetric Boundary

Author(s): S.A. Angayarkani, N. Kampf, J. Klein
Published in: Langmuir, 2020, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.0c02956

Designer Liposomic Nanocarriers Are Effective Biofilm Eradicators

Author(s): Monika Kluzek, Yaara Oppenheimer-Shaanan, Tali Dadosh, Mattia I. Morandi, Ori Avinoam, Calanit Raanan, Moshe Goldsmith, Ronit Goldberg, and Jacob Klein
Published in: ACS Nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c04232

Poly-phosphocholination of liposomes leads to highly-extended retention time in mice joints

Author(s): W. Lin, R. Goldberg, J. Klein
Published in: J. Materials Chemistry - B, 2022, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tb02346b

The Role of Hyaluronic Acid in Cartilage Boundary Lubrication

Author(s): Weifeng Lin, Zhang Liu, Nir Kampf, Jacob Klein
Published in: Cells, Issue 9/7, 2020, Page(s) 1606, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9071606

Lubrication of articular cartilage

Author(s): Sabrina Jahn, Jacob Klein
Published in: Physics Today, Issue 71/4, 2018, Page(s) 48-54, ISSN 0031-9228
Publisher: American Institute of Physics
DOI: 10.1063/pt.3.3898

Charging dynamics of an individual nanopore

Author(s): Ran Tivony, Sam Safran, Philip Pincus, Gilad Silbert, Jacob Klein
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06364-1

Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction

Author(s): Weifeng Lin, Reut Mashiah, Jasmine Seror, Assaf Kadar, Oleg Dolkart, Tamir Pritsch, Ronit Goldberg, Jacob Klein
Published in: Acta Biomaterialia, Issue 83, 2019, Page(s) 314-321, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.11.015

Trapped Aqueous Films Lubricate Highly Hydrophobic Surfaces

Author(s): Irit Rosenhek-Goldian, Nir Kampf, Jacob Klein
Published in: ACS Nano, Issue 12/10, 2018, Page(s) 10075-10083, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b04735

Control of surface forces through hydrated boundary layers

Author(s): Weifeng Lin, Jacob Klein
Published in: Current Opinion in Colloid & Interface Science, Issue 44, 2019, Page(s) 94-106, ISSN 1359-0294
Publisher: Pergamon Press
DOI: 10.1016/j.cocis.2019.10.001

Normal and shear forces between boundary sphingomyelin layers under aqueous conditions

Author(s): Yifeng Cao, Nir Kampf, Weifeng Lin, Jacob Klein
Published in: Soft Matter, 2020, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm00215a

Surface Interactions between Boundary Layers of Poly(ethylene oxide)–Liposome Complexes: Lubrication, Bridging, and Selective Ligation

Author(s): S. A. Angayarkanni, Nir Kampf, Jacob Klein
Published in: Langmuir, Issue 35/48, 2019, Page(s) 15469-15480, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01708

Origins of the long-ranged attraction between surfaces that were rendered hydrophobic by surfactant layers

Author(s): Jacob Klein
Published in: Advances in Colloid and Interface Science, Issue 270, 2019, Page(s) 261-262, ISSN 0001-8686
Publisher: Elsevier BV
DOI: 10.1016/j.cis.2019.06.009

Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors

Author(s): Weifeng Lin, Nir Kampf, Ronit Goldberg, Michael J. Driver, Jacob Klein
Published in: Langmuir, Issue 35/18, 2019, Page(s) 6048-6054, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b00610

Boundary Lubrication, Hemifusion, and Self-Healing of Binary Saturated and Monounsaturated Phosphatidylcholine Mixtures

Author(s): Yifeng Cao, Nir Kampf, Jacob Klein
Published in: Langmuir, Issue 35/48, 2019, Page(s) 15459-15468, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01660

Recent Progress in Cartilage Lubrication

Author(s): Weifeng Lin, Jacob Klein
Published in: Advanced Materials, 2021, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202005513

Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels

Author(s): Weifeng Lin, jacob Klein
Published in: Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels, 2022, ISSN 2643-6728
Publisher: American Chemical Society
DOI: 10.1021/accountsmr.1c00219

Effects of Hyaluronan Molecular Weight on the Lubrication of Cartilage-Emulating Boundary Layers

Author(s): Zhang Liu, Weifeng Lin, Yaxun Fan, Nir Kampf, Yilin Wang, Jacob Klein
Published in: Biomacromolecules, Issue 21/10, 2020, Page(s) 4345-4354, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c01151

Interactions Between Bilayers of Phospholipids Extracted from Human Osteoarthritic Synovial Fluid

Author(s): Yifeng Cao, Nir Kampf, Marta Krystyna Kosinska, Juergen Steinmeyer, Jacob Klein
Published in: Biotribology, 2021, ISSN 2352-5738
Publisher: Elsevier
DOI: 10.1016/j.biotri.2020.100157

Cartilage inspired, lipid-based boundary lubricated hydrogels

Author(s): Lin, W-F, Kluzek, M., Iuster, N., Shimoni, E., Kampf, N., Goldberg, R., Klein, J.
Published in: Science, Issue Weekly, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay8276