Lubricating Cartilage: exploring the relation between lubrication and gene-regulation to alleviate osteoarthritis

Informazioni relative al progetto

CartiLube

ID dell’accordo di sovvenzione: 743016

DOI 10.3030/743016

Progetto chiuso

Data della firma CE 19 Luglio 2017

Data di avvio 1 Settembre 2017

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 499 944,00

Contributo UE € 2 499 944,00

Coordinato da

WEIZMANN INSTITUTE OF SCIENCE
Israel

Pubblicazioni

Peer reviewed articles (28)

Dehydration does not affect lipid-based hydrationlubrication

Autori: Yihui Dong, Nir Kampf, Yaelle Schilt, Wei Cao, Uri Raviv and Jacob Klein
Pubblicato in: Nanoscale, 2022, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d2nr04799c

Lipids and lipid-mixtures in boundary layers: from hydration lubrication to osteoarthritis

Autori: Y. Cao, J. Klein
Pubblicato in: Current Opinions in Colloid and Interface Science, 2022, ISSN 1359-0294
Editore: Pergamon Press
DOI: 10.1016/j.cocis.2021.101559

Direct measurement of surface forces: Recent advances and insights

Autori: W. Lin, J. Klein
Pubblicato in: Applied Physics Reviews, 2021, ISSN 1931-9401
Editore: AIP Publishing LLC
DOI: 10.1063/5.0059893

Modulating Interfacial Energy Dissipation via Potential-Controlled Ion Trapping

Autori: R. Tivony, Y. Zhang, J. Klein
Pubblicato in: J. Phys. Chem.C, 2020, ISSN 1932-7447
Editore: American Chemical Society
DOI: 10.1021/acs.jpcc.0c11264

Designer Nanoparticles as Robust Superlubrication Vectors

Autori: Weifeng Lin, Nir Kampf, Jacob Klein
Pubblicato in: ACS Nano, Numero 14/6, 2020, Pagina/e 7008-7017, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.0c01559

Direct measurement of the viscoelectric effect in water

Autori: Jin, D., Hwang, Y., Nir Kampf , N. and Klein, J.
Pubblicato in: Proceeding of the National Academy of Science (PNAS, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2113690119

Effect of cholesterol on the mechanical stability of gel-phase phospholipid bilayers studied by AFM force spectroscopy

Autori: Salomé Mielke , Raya Sorkin , Jacob Klein
Pubblicato in: EPJ E, 2023, ISSN 1292-8941
Editore: Springer Verlag
DOI: 10.1140/epje/s10189-023-00338-y

Neutral polyphosphocholine-modified liposomes as boundary superlubricants

Autori: Weifeng Lin, Nir Kampf, Jacob Klein
Pubblicato in: Colloids and Surfaces A, 2022, ISSN 1873-4359
Editore: Elsevier
DOI: 10.1016/j.colsurfa.2022.129218

Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice

Autori: Clarissa R. Coveney, Linyi Zhu, Jadwiga Miotla-Zarebska, Bryony Stott, Ida Parisi, Vicky Batchelor, Claudia Duarte, Emer Chang, Eleanor McSorley, Tonia L. Vincent, Angus K. T. Wann
Pubblicato in: Arthritis and Rheumatology, 2021, ISSN 2326-5191
Editore: American College of Rheumatology
DOI: 10.1002/art.41894

Lipid-Bilayer Assemblies on Polymer-Bearing Surfaces: The Nature of the Slip Plane in Asymmetric Boundary Lubrication: The Nature of the Slip Plane in Asymmetric Boundary

Autori: S.A. Angayarkani, N. Kampf, J. Klein
Pubblicato in: Langmuir, 2020, ISSN 0743-7463
Editore: American Chemical Society
DOI: 10.1021/acs.langmuir.0c02956

Designer Liposomic Nanocarriers Are Effective Biofilm Eradicators

Autori: Monika Kluzek, Yaara Oppenheimer-Shaanan, Tali Dadosh, Mattia I. Morandi, Ori Avinoam, Calanit Raanan, Moshe Goldsmith, Ronit Goldberg, and Jacob Klein
Pubblicato in: ACS Nano, 2022, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.2c04232

Poly-phosphocholination of liposomes leads to highly-extended retention time in mice joints

Autori: W. Lin, R. Goldberg, J. Klein
Pubblicato in: J. Materials Chemistry - B, 2022, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/d1tb02346b

The Role of Hyaluronic Acid in Cartilage Boundary Lubrication

Autori: Weifeng Lin, Zhang Liu, Nir Kampf, Jacob Klein
Pubblicato in: Cells, Numero 9/7, 2020, Pagina/e 1606, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9071606

Lubrication of articular cartilage

Autori: Sabrina Jahn, Jacob Klein
Pubblicato in: Physics Today, Numero 71/4, 2018, Pagina/e 48-54, ISSN 0031-9228
Editore: American Institute of Physics
DOI: 10.1063/pt.3.3898

Charging dynamics of an individual nanopore

Autori: Ran Tivony, Sam Safran, Philip Pincus, Gilad Silbert, Jacob Klein
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-06364-1

Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction

Autori: Weifeng Lin, Reut Mashiah, Jasmine Seror, Assaf Kadar, Oleg Dolkart, Tamir Pritsch, Ronit Goldberg, Jacob Klein
Pubblicato in: Acta Biomaterialia, Numero 83, 2019, Pagina/e 314-321, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2018.11.015

Trapped Aqueous Films Lubricate Highly Hydrophobic Surfaces

Autori: Irit Rosenhek-Goldian, Nir Kampf, Jacob Klein
Pubblicato in: ACS Nano, Numero 12/10, 2018, Pagina/e 10075-10083, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.8b04735

Control of surface forces through hydrated boundary layers

Autori: Weifeng Lin, Jacob Klein
Pubblicato in: Current Opinion in Colloid & Interface Science, Numero 44, 2019, Pagina/e 94-106, ISSN 1359-0294
Editore: Pergamon Press
DOI: 10.1016/j.cocis.2019.10.001

Normal and shear forces between boundary sphingomyelin layers under aqueous conditions

Autori: Yifeng Cao, Nir Kampf, Weifeng Lin, Jacob Klein
Pubblicato in: Soft Matter, 2020, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sm00215a

Surface Interactions between Boundary Layers of Poly(ethylene oxide)–Liposome Complexes: Lubrication, Bridging, and Selective Ligation

Autori: S. A. Angayarkanni, Nir Kampf, Jacob Klein
Pubblicato in: Langmuir, Numero 35/48, 2019, Pagina/e 15469-15480, ISSN 0743-7463
Editore: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01708

Origins of the long-ranged attraction between surfaces that were rendered hydrophobic by surfactant layers

Autori: Jacob Klein
Pubblicato in: Advances in Colloid and Interface Science, Numero 270, 2019, Pagina/e 261-262, ISSN 0001-8686
Editore: Elsevier BV
DOI: 10.1016/j.cis.2019.06.009

Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors

Autori: Weifeng Lin, Nir Kampf, Ronit Goldberg, Michael J. Driver, Jacob Klein
Pubblicato in: Langmuir, Numero 35/18, 2019, Pagina/e 6048-6054, ISSN 0743-7463
Editore: American Chemical Society
DOI: 10.1021/acs.langmuir.9b00610

Boundary Lubrication, Hemifusion, and Self-Healing of Binary Saturated and Monounsaturated Phosphatidylcholine Mixtures

Autori: Yifeng Cao, Nir Kampf, Jacob Klein
Pubblicato in: Langmuir, Numero 35/48, 2019, Pagina/e 15459-15468, ISSN 0743-7463
Editore: American Chemical Society
DOI: 10.1021/acs.langmuir.9b01660

Recent Progress in Cartilage Lubrication

Autori: Weifeng Lin, Jacob Klein
Pubblicato in: Advanced Materials, 2021, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202005513

Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels

Autori: Weifeng Lin, jacob Klein
Pubblicato in: Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels, 2022, ISSN 2643-6728
Editore: American Chemical Society
DOI: 10.1021/accountsmr.1c00219

Effects of Hyaluronan Molecular Weight on the Lubrication of Cartilage-Emulating Boundary Layers

Autori: Zhang Liu, Weifeng Lin, Yaxun Fan, Nir Kampf, Yilin Wang, Jacob Klein
Pubblicato in: Biomacromolecules, Numero 21/10, 2020, Pagina/e 4345-4354, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.0c01151

Interactions Between Bilayers of Phospholipids Extracted from Human Osteoarthritic Synovial Fluid

Autori: Yifeng Cao, Nir Kampf, Marta Krystyna Kosinska, Juergen Steinmeyer, Jacob Klein
Pubblicato in: Biotribology, 2021, ISSN 2352-5738
Editore: Elsevier
DOI: 10.1016/j.biotri.2020.100157

Cartilage inspired, lipid-based boundary lubricated hydrogels

Autori: Lin, W-F, Kluzek, M., Iuster, N., Shimoni, E., Kampf, N., Goldberg, R., Klein, J.
Pubblicato in: Science, Numero Weekly, 2020, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aay8276