Molecular Biology of Nascent Chains: Co-translational folding and assembly of proteins in eukaryotes

Project Information

TransFold

Grant agreement ID: 743118

DOI 10.3030/743118

Project closed

EC signature date 19 July 2017

Start date 1 October 2017

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 069 000,00

EU contribution € 2 069 000,00

Coordinated by

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

Publications

Peer reviewed articles (10)

Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae

Author(s): Ajeet K Sharma, Johannes Venezian, Ayala Shiber, Günter Kramer, Bernd Bukau, Edward P O'Brien
Published in: Proc Natl Acad Sci U S A, Issue 118, 2021, Page(s) e2026362118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2026362118

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Author(s): Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro
Published in: Nature, Issue 603, 2022, Page(s) 509-514, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04487-6

Nα-terminal acetylation of proteins by NatA and NatB serves distinct physiological roles in Saccharomyces cerevisiae

Author(s): Ulrike Anne Friedrich; Mostafa Zedan; Bernd Hessling; Kai Fenzl; Ludovic C Gillet; Joseph Barry; Michael Knop; Günter Kramer; Bernd Bukau
Published in: Cell Reports, Issue 34, 2021, Page(s) 108711, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1101/843953

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates

Author(s): Nabeel Ahmed; Ulrike A. Friedrich; Ulrike A. Friedrich; Pietro Sormanni; Prajwal Ciryam; Naomi Altman; Bernd Bukau; Bernd Bukau; Günter Kramer; Günter Kramer; Edward P. O'Brien
Published in: Journal of Molecular Biology, Issue 432, 2020, Page(s) 166696, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1101/2020.04.20.051839

Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

Author(s): Jonathan Bohlen, Kai Fenzl, Günter Kramer, Bernd Bukau, Aurelio A Teleman
Published in: Molecular Cell, Issue 79, 2020, Page(s) 561-574.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.06.005

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

Author(s): Ayala Shiber, Kristina Döring, Ulrike Friedrich, Kevin Klann, Dorina Merker, Mostafa Zedan, Frank Tippmann, Günter Kramer, Bernd Bukau
Published in: Nature, Issue 561/7722, 2018, Page(s) 268-272, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0462-y

Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins

Author(s): Günter Kramer, Ayala Shiber, Bernd Bukau
Published in: Annual Review of Biochemistry, Issue 88/1, 2019, Page(s) 337-364, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-013118-111717

Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding

Author(s): Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P. Mayer, Edward P. O’Brien, Günter Kramer, Bernd Bukau
Published in: Cell, Issue 170/2, 2017, Page(s) 298-311.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.06.038

DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

Author(s): Jonathan Bohlen, Liza Harbrecht, Saioa Blanco, Katharina Clemm von Hohenberg, Kai Fenzl, Günter Kramer, Bernd Bukau, Aurelio A Teleman
Published in: Nature Communications, Issue 11, 2020, Page(s) 4676, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18452-2

Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly.

Author(s): Matilde Bertolini; Kai Fenzl; Ilia Kats; Florian Wruck; Frank Tippmann; Jaro Schmitt; Josef J. Auburger; Sander J. Tans; Bernd Bukau; Günter Kramer
Published in: Science, Issue 371, 2021, Page(s) 57-64, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abc7151