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Molecular Biology of Nascent Chains: Co-translational folding and assembly of proteins in eukaryotes

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae

Author(s): Ajeet K Sharma, Johannes Venezian, Ayala Shiber, Günter Kramer, Bernd Bukau, Edward P O'Brien
Published in: Proc Natl Acad Sci U S A, Issue 118, 2021, Page(s) e2026362118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2026362118

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Author(s): Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro
Published in: Nature, Issue 603, 2022, Page(s) 509-514, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04487-6

Nα-terminal acetylation of proteins by NatA and NatB serves distinct physiological roles in Saccharomyces cerevisiae

Author(s): Ulrike Anne Friedrich; Mostafa Zedan; Bernd Hessling; Kai Fenzl; Ludovic C Gillet; Joseph Barry; Michael Knop; Günter Kramer; Bernd Bukau
Published in: Cell Reports, Issue 34, 2021, Page(s) 108711, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1101/843953

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates

Author(s): Nabeel Ahmed; Ulrike A. Friedrich; Ulrike A. Friedrich; Pietro Sormanni; Prajwal Ciryam; Naomi Altman; Bernd Bukau; Bernd Bukau; Günter Kramer; Günter Kramer; Edward P. O'Brien
Published in: Journal of Molecular Biology, Issue 432, 2020, Page(s) 166696, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1101/2020.04.20.051839

Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

Author(s): Jonathan Bohlen, Kai Fenzl, Günter Kramer, Bernd Bukau, Aurelio A Teleman
Published in: Molecular Cell, Issue 79, 2020, Page(s) 561-574.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.06.005

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

Author(s): Ayala Shiber, Kristina Döring, Ulrike Friedrich, Kevin Klann, Dorina Merker, Mostafa Zedan, Frank Tippmann, Günter Kramer, Bernd Bukau
Published in: Nature, Issue 561/7722, 2018, Page(s) 268-272, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0462-y

Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins

Author(s): Günter Kramer, Ayala Shiber, Bernd Bukau
Published in: Annual Review of Biochemistry, Issue 88/1, 2019, Page(s) 337-364, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-013118-111717

Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding

Author(s): Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P. Mayer, Edward P. O’Brien, Günter Kramer, Bernd Bukau
Published in: Cell, Issue 170/2, 2017, Page(s) 298-311.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.06.038

DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

Author(s): Jonathan Bohlen, Liza Harbrecht, Saioa Blanco, Katharina Clemm von Hohenberg, Kai Fenzl, Günter Kramer, Bernd Bukau, Aurelio A Teleman
Published in: Nature Communications, Issue 11, 2020, Page(s) 4676, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18452-2

Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly.

Author(s): Matilde Bertolini; Kai Fenzl; Ilia Kats; Florian Wruck; Frank Tippmann; Jaro Schmitt; Josef J. Auburger; Sander J. Tans; Bernd Bukau; Günter Kramer
Published in: Science, Issue 371, 2021, Page(s) 57-64, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abc7151

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