Molecular Biology of Nascent Chains: Co-translational folding and assembly of proteins in eukaryotes

Publicaciones

Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae

Autores: Ajeet K Sharma, Johannes Venezian, Ayala Shiber, Günter Kramer, Bernd Bukau, Edward P O'Brien
Publicado en: Proc Natl Acad Sci U S A, Edición 118, 2021, Página(s) e2026362118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2026362118

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Autores: Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A P Joazeiro
Publicado en: Nature, Edición 603, 2022, Página(s) 509-514, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04487-6

Nα-terminal acetylation of proteins by NatA and NatB serves distinct physiological roles in Saccharomyces cerevisiae

Autores: Ulrike Anne Friedrich; Mostafa Zedan; Bernd Hessling; Kai Fenzl; Ludovic C Gillet; Joseph Barry; Michael Knop; Günter Kramer; Bernd Bukau
Publicado en: Cell Reports, Edición 34, 2021, Página(s) 108711, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1101/843953

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates

Autores: Nabeel Ahmed; Ulrike A. Friedrich; Ulrike A. Friedrich; Pietro Sormanni; Prajwal Ciryam; Naomi Altman; Bernd Bukau; Bernd Bukau; Günter Kramer; Günter Kramer; Edward P. O'Brien
Publicado en: Journal of Molecular Biology, Edición 432, 2020, Página(s) 166696, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1101/2020.04.20.051839

Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

Autores: Jonathan Bohlen, Kai Fenzl, Günter Kramer, Bernd Bukau, Aurelio A Teleman
Publicado en: Molecular Cell, Edición 79, 2020, Página(s) 561-574.e5, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2020.06.005

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

Autores: Ayala Shiber, Kristina Döring, Ulrike Friedrich, Kevin Klann, Dorina Merker, Mostafa Zedan, Frank Tippmann, Günter Kramer, Bernd Bukau
Publicado en: Nature, Edición 561/7722, 2018, Página(s) 268-272, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0462-y

Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins

Autores: Günter Kramer, Ayala Shiber, Bernd Bukau
Publicado en: Annual Review of Biochemistry, Edición 88/1, 2019, Página(s) 337-364, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-013118-111717

Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding

Autores: Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P. Mayer, Edward P. O’Brien, Günter Kramer, Bernd Bukau
Publicado en: Cell, Edición 170/2, 2017, Página(s) 298-311.e20, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2017.06.038

DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

Autores: Jonathan Bohlen, Liza Harbrecht, Saioa Blanco, Katharina Clemm von Hohenberg, Kai Fenzl, Günter Kramer, Bernd Bukau, Aurelio A Teleman
Publicado en: Nature Communications, Edición 11, 2020, Página(s) 4676, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-18452-2

Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly.

Autores: Matilde Bertolini; Kai Fenzl; Ilia Kats; Florian Wruck; Frank Tippmann; Jaro Schmitt; Josef J. Auburger; Sander J. Tans; Bernd Bukau; Günter Kramer
Publicado en: Science, Edición 371, 2021, Página(s) 57-64, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abc7151

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