A Functional, Mature In vivo Human Ventricular Muscle Patch for Cardiomyopathy

Project Information

5D Heart Patch

Grant agreement ID: 743225

DOI

10.3030/743225

Project terminated on 31 May 2022

EC signature date 23 November 2017

Start date 1 December 2017

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 149 227,50

EU contribution

€ 2 149 227,50

Coordinated by

KAROLINSKA INSTITUTET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage

Author(s): Mimmi M. Mononen, Chuen Yan Leung, Jiejia Xu, Kenneth R. Chien
Published in: STEM CELLS, Issue Volume38, Issue10, 2020, Page(s) 1267-1278, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3236

An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation.

Author(s): Eduarde Rohner; Nevin Witman; Jesper Sohlmer; Erwin De Genst; William E. Louch; William E. Louch; Makoto Sahara; Makoto Sahara; Kenneth R. Chien
Published in: Molecular Medicine, Issue 27, 2021, Page(s) 102, ISSN 1528-3658
Publisher: Springer Nature
DOI: 10.1186/s10020-021-00362-8

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors.

Author(s): Poch CM, Foo KS, De Angelis MT, Jennbacken K, Santamaria G, Bähr A, Wang Q-D, Reiter F, Hornaschewitz F, Bozoglu T, My I, Meier A, Dorn T, Zawada D, Tsoi YT, Lehtien ML, Hovdal D, Hyllner J, Schwarz S, Juritsch V, Sini M, Fellows MD, Cummings M, Clarke J, Baptista R, Eroglu E, Tomasi R, Dendorfer A, Gaspari M, Cuda G, Krane M, Daniel Sinnecker D, Hoppmann P, Kupatt C, Fritsche-Danielson R, Moret
Published in: Nat Cell Biol., Issue 2022 May;24(5), 2022, Page(s) 659–671, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00899-8

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

Author(s): Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, Boogerd CJ, Frisk M, van Rooij E, Damle S, Louch WE, Wang QD, Fritsche-Danielson R, Chien KR, Hansson KM, Mullick AE, de Boer RA, van der Meer P
Published in: Nat Commun, Issue 2021 Aug 30;12(1) Article number: 5180, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25439-0

Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in a heart failure model.

Author(s): Erwin De Genst, Kylie Foo, Yao Xiao, Eduarde Rohner, Emma De Vries, Jesper Sohlmér, Nevin Witman, Alejandro Hildago-Gonzalez, Terje Selnes Kolstad, William E. Louch, Kate Wickson, Lorenz Mayr, Susanne Pehrsson, Andrew Park, Yasuhiro Ikeda, Karin Jennbacken, Kenny M Hansson, Regina Fritsche-Danielson, James Hunt, Kenneth R Chien
Published in: Nat Commun., Issue 2022 May 31;13(1):3018, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29703-9

Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors

Author(s): Jiejia Xu, Chikai Zhou, Kylie S. Foo, Ran Yang, Yao Xiao, Kristine Bylund, Makoto Sahara, Kenneth R. Chien
Published in: STEM CELLS, Issue 38/6, 2020, Page(s) 741-755, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3168

Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction

Author(s): Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On-tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao-Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien
Published in: Molecular Therapy, Issue 26/7, 2018, Page(s) 1644-1659, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.02.012

Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract

Author(s): Makoto Sahara, Federica Santoro, Jesper Sohlmér, Chikai Zhou, Nevin Witman, Chuen Yan Leung, Mimmi Mononen, Kristine Bylund, Peter Gruber, Kenneth R. Chien
Published in: Developmental Cell, Issue 48/4, 2019, Page(s) 475-490.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.01.005

Corrigendum to “Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration” [Semin. Cell Dev. Biol. Vol.100 (2020) 29–51]

Author(s): Nevin Witman, Chikai Zhou, Niels Grote Beverborg, Makoto Sahara, Kenneth R. Chien
Published in: Seminars in Cell & Developmental Biology, Issue Vol 100, 2020, Page(s) 29-51, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2020.09.008