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Publications

Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance

Author(s): Jan Padeken, Stephen P Methot, Susan M Gasser
Published in: Nature Reviews Molecular Cell Biology, 2022, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-022-00483-w

Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.

Author(s): Jan Padeken; Stephen P. Methot; Peter Zeller; Peter Zeller; Colin Delaney; Véronique Kalck; Susan M. Gasser; Susan M. Gasser
Published in: Genes and Development, 1, 2020, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.344234.120

Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.

Author(s): Jennifer C. Harr; Christoph D. Schmid; Celia Muñoz-Jiménez; Raquel Romero-Bueno; Véronique Kalck; Adriana Gonzalez-Sandoval; Michael H. Hauer; Jan Padeken; Peter Askjaer; Anna Mattout; Susan M. Gasser; Susan M. Gasser
Published in: Genes and Development, 2, 2022, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.332213.119

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

Author(s): Stephen P. Methot, Jan Padeken, Giovanna Brancati, Peter Zeller, Colin E. Delaney, Dimos Gaidatzis, Hubertus Kohler, Alexander van Oudenaarden, Helge Großhans & Susan M. Gasser
Published in: Nature Cell Biology, 2021, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00776-w

Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65

Author(s): Colin E. Delaney, Stephen P. Methot, Micol Guidi, Iskra Katic, Susan M. Gasser, Jan Padeken
Published in: The Journal of Cell Biology, 218/3, 2019, Page(s) 820-838, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201811038

Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei

Author(s): Daphne S. Cabianca, Celia Muñoz-Jiménez, Véronique Kalck, Dimos Gaidatzis, Jan Padeken, Andrew Seeber, Peter Askjaer, Susan M. Gasser
Published in: Nature, 569/7758, 2019, Page(s) 734-739, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1243-y

Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression

Author(s): Jan Padeken, Peter Zeller, Benjamin Towbin, Iskra Katic, Veronique Kalck, Stephen P. Methot, Susan M. Gasser
Published in: Genes & Development, 33/7-8, 2019, Page(s) 436-451, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.322495.118

LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay

Author(s): Anna Mattout, Dimos Gaidatzis, Jan Padeken, Christoph D. Schmid, Florian Aeschimann, Véronique Kalck & Susan M. Gasser
Published in: Nature Cell Biology, 2020, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0504-1

SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

Author(s): Colin E. Delaney, Stephen P. Methot, Veronique Kalck, Jan Seebacher, Daniel Hess, Susan M. Gasser & Jan Padeken
Published in: Nature Structural and Molecular Biology, 2022, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00712-4