Writing, reading and managing stress with H3K9me

Project Information

Epiherigans

Grant agreement ID: 743312

DOI

10.3030/743312

Project closed

EC signature date 24 May 2017

Start date 1 June 2017

End date 31 May 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

UNIVERSITE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance

Author(s): Jan Padeken, Stephen P Methot, Susan M Gasser
Published in: Nature Reviews Molecular Cell Biology, 2022, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-022-00483-w

Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.

Author(s): Jan Padeken; Stephen P. Methot; Peter Zeller; Peter Zeller; Colin Delaney; Véronique Kalck; Susan M. Gasser; Susan M. Gasser
Published in: Genes and Development, Issue 1, 2020, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.344234.120

Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.

Author(s): Jennifer C. Harr; Christoph D. Schmid; Celia Muñoz-Jiménez; Raquel Romero-Bueno; Véronique Kalck; Adriana Gonzalez-Sandoval; Michael H. Hauer; Jan Padeken; Peter Askjaer; Anna Mattout; Susan M. Gasser; Susan M. Gasser
Published in: Genes and Development, Issue 2, 2022, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.332213.119

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

Author(s): Stephen P. Methot, Jan Padeken, Giovanna Brancati, Peter Zeller, Colin E. Delaney, Dimos Gaidatzis, Hubertus Kohler, Alexander van Oudenaarden, Helge Großhans & Susan M. Gasser
Published in: Nature Cell Biology, 2021, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00776-w

Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65

Author(s): Colin E. Delaney, Stephen P. Methot, Micol Guidi, Iskra Katic, Susan M. Gasser, Jan Padeken
Published in: The Journal of Cell Biology, Issue 218/3, 2019, Page(s) 820-838, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201811038

Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei

Author(s): Daphne S. Cabianca, Celia Muñoz-Jiménez, Véronique Kalck, Dimos Gaidatzis, Jan Padeken, Andrew Seeber, Peter Askjaer, Susan M. Gasser
Published in: Nature, Issue 569/7758, 2019, Page(s) 734-739, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1243-y

Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression

Author(s): Jan Padeken, Peter Zeller, Benjamin Towbin, Iskra Katic, Veronique Kalck, Stephen P. Methot, Susan M. Gasser
Published in: Genes & Development, Issue 33/7-8, 2019, Page(s) 436-451, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.322495.118

LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay

Author(s): Anna Mattout, Dimos Gaidatzis, Jan Padeken, Christoph D. Schmid, Florian Aeschimann, Véronique Kalck & Susan M. Gasser
Published in: Nature Cell Biology, 2020, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0504-1

SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

Author(s): Colin E. Delaney, Stephen P. Methot, Veronique Kalck, Jan Seebacher, Daniel Hess, Susan M. Gasser & Jan Padeken
Published in: Nature Structural and Molecular Biology, 2022, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00712-4