Periodic Reporting for period 1 - u-PBeam (Microdosimetry study of a new radiation therapy method based on proton minibeams)
Período documentado: 2017-10-01 hasta 2019-09-30
This project has an important social impact since it addressed the first pre-clinical studies for the implementation in a proton therapy center (ICPO, France). It will be the first place where it is expected that it will be implemented in patients worldwide.
The main objectives have been focused on performing a multidisciplinar study by (i) optimizing the generation method of p-MBRT in a clinical center with Monte Carlo simulations, (ii) performing new 3D-microdetectors able to be used at clinical fluence rates, and (iii) developing radiobiology studies with that new modality.
Secondly, we peformed experimental tests in hadron beam lines with a new generation of 3D-microdetectors. Results showed a good agreement between experimental and simulated microdosimetric distributions even at the high fluence rates associated with clinical beams.
Third,we report on the first in vitro study performed in an X-ray Small Animal Radiation Research Platform (SARRP) modified for minibeam irradiations. F98 rat and U87 human glioma cells were irradiated with either an array of minibeams or with conventional homogeneous beams. We conclude that MBRT has the potential to improve the therapeutic index for gliomas