Objective
Vector-borne diseases represent one of the greatest public health challenges. Their incidence and their geographical range have dramatically increased over the past several decades. Due to the lack of protective vaccines, the control of transmission by targeting the mosquito vectors is the only affordable measure. However, mosquito vectors experience a very intense selective pressure from insecticides, which has led ultimately to the selection of insecticide resistance in many vector species. Alternative control strategies that are species-specific and environmentally friendly are being developed. Among them, the use of the symbiotic bacteria Wolbachia as sterilizing agent of mosquito populations through the incompatible insect technique (IIT) appears promising. Furthermore, it was shown that insecticides as well as Wolbachia can affect the infection of mosquitoes by pathogens, and thus their transmission. An important question is how mosquitoes' adaptations to insecticides and to Wolbachia influence the vector competence for pathogens? This proposal addresses this question in the context of the emergence of Chikungunya worldwide in order to sustainably control its transmission with current and prospective vector control tools. It addresses in particular the question whether there are any interactions between insecticide resistance and symbiotic Wolbachia infection that might significantly affect the vector competence of Aedes albopictus for Chikungunya virus. Characterizing the genes likely involved in vector competence and how they can be modulated to alter this trait will provide valuable data for management of transmission control strategies. It will allow a more rational use of insecticides, as well as the development of alternative control methods based on Wolbachia; both approaches are crucial in the context of widespread insecticide resistance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- medical and health sciences health sciences public health
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences health sciences nutrition
- natural sciences biological sciences zoology invertebrate zoology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.