Objetivo Malaria, Zika virus, dengue fever and yellow fever are mosquito transmitted diseases for which a vaccines either do not exists or are not widely available. Prevention control is the main way to reduce their spread, and the use of insecticides constitutes one of the key measures recommended by World Health Organisation. New innovative methods of bringing the insects into contact with the insecticides include the development of insecticidal paint with the advantage of safer application, targeted dosing and significantly reduced risk of collateral damage to humans and the environment. This project will address some of the challenges in developing these solutions. Pyrethroids are one of the best insecticides for public health use but suffer from hydrolysis and photo-degradation. Little is known about how their application in paint formulations affects this behavior. At a chemical level the biological activity of the individual enantiomers is determined by the configuration of their chiral centers, so accurately quantifying the enantiomeric composition is critical to tracking potential degradation. The aim of this project is to generate robust methods for a better understanding of the fate of insecticides in complex matrices like paint. Once the nature of the degradation products and the related mechanisms is clear, the formulation can be adjusted to minimize the occurrence of degradation or enhance active ingredient protection. The kinetic analysis of the degradation processes and the interaction/stability studies are best performed in-situ avoiding potentially invasive extraction sample preparation steps, so the powerful tools of advanced NMR spectroscopy will be exploited to characterize these phenomena. The knowledge gained will be used to validate/explain multidisciplinary laboratory biological trial results on mosquitoes and be able to be exploited more widely to other systems and support the research into other compounds for potential deployment in this way. Ámbito científico medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural sciencesbiological scienceszoologyentomologynatural sciencesbiological scienceszoologyinvertebrate zoology Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2016 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2016 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-SE - Society and Enterprise panel Coordinador NOURYON CHEMICALS B.V. Aportación neta de la UEn € 165 598,80 Dirección VELPERWEG 76 6824 BM ARNHEM Países Bajos Ver en el mapa Región Oost-Nederland Gelderland Arnhem/Nijmegen Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 165 598,80
