Impact of Intrapartum Antimicrobial Prophylaxis as an early determinant in Microbiome Development

Información del proyecto

IAPEMIDE

Identificador del acuerdo de subvención: 749255

DOI

10.3030/749255

Proyecto finalizado el 13 Julio 2019

Fecha de la firma de la CE 17 Marzo 2017

Fecha de inicio 1 Agosto 2017

Fecha de finalización 31 Julio 2019

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 158 121,60

Aportación de la UE

€ 158 121,60

Coordinado por

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Objetivo

During the last decades, changes in diet and lifestyle have increased the risk of non-communicable diseases in the western countries. It is known that once they are established in the childhood, they continue into adult life with the associated negative impact on health, quality of life and health care costs. The correct establishment of the intestinal microbiota (IM) at the beginning of life plays a key role in health, reducing risk of chronic disease. Some factors affecting this process have been studied; however, other like the intrapartum antimicrobial prophylaxis (IAP), in spite of been present on over 30% of total deliveries, have been much less studied. It is already known that at least 11 types of broad-spectrum antibiotics cross the placenta and reach the foetus. Given the increasingly evident relationship between early microbiota, later disease risk and the rising worries regarding antimicrobial resistances, there is an urgent need to assess the potential adverse consequences of IAP in the establishment of the IM and resistome. This project will be the first to study mechanisms orchestrating the impact of IAP on the neonatal IM establishment. The objectives are: identify the alterations induced by IAP in the neonatal IM development; identify the antibiotic resistance genes that the IM carried as consequence of IAP; study the potential role of infant feeding in the modulation of the microbiota after IAP administration and design of specific dietary strategies for minimising the impact of IAP on the IM establishment. Moreover, if the breast-milk exerts a protective role, it would help to strengthen the maternal breast-feeding recommendations. Following this study, doctors will be better able to address the consequences to make knowledge-based decisions about IAP treatment in those situations where it is not extremely mandatory. Besides, the present project will represent a worthy opportunity for the applicant to improve her research competences and career.

Ámbito científico (EuroSciVoc)

• ciencias médicas y de la salud › medicina básica › inmunología
• ciencias médicas y de la salud › medicina básica › farmacología y farmacia › medicamento › antibióticos
• ciencias médicas y de la salud › medicina básica › farmacología y farmacia › farmacorresistencia › resistencia a antibióticos
• ciencias médicas y de la salud › medicina básica › fisiología › homeostasis
• ciencias médicas y de la salud › ciencias de la salud › nutrición › obesidad

Palabras clave

• probiotics
• neonates
• gut
• microbiota
• intrapartum antimicrobial prophylaxis
• dietary interventions

Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions PROGRAMA PRINCIPAL
  
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
  

Tema(s)

• MSCA-IF-2016 - Individual Fellowships
  

Régimen de financiación

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Convocatoria de propuestas

H2020-MSCA-IF-2016

Coordinador

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

• Aportación neta de la UEn: € 158 121,60
• Dirección: CALLE SERRANO 117 ; 28006 MADRID ; España
• Región: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Tipo de actividad: Research Organisations
• Coste total: € 158 121,60