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MRI Signal To Recover Unique Cerebral TissUe Response to changEs

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

Objective

MRI-STRUCTURE is an innovative non-invasive imaging framework that will provide access to unexplored microstructural information in brain, targeting the scarcity of microstructural models able to extract meaningful biomarkers from the diffusion MRI signal in grey matter (GM). It is based on a synergy between different approaches: simulations, modeling, acquisition and analysis of real data, implementation of rodent model of brain insults, translation to human. The final aim of the project is to increase our knowledge of brain structure in health and disease, with a special focus on the themes of neuroinflammation, demyelination and axon degeneration. These physiological processes are interplaying phenomena involved in the brain’s reaction to different stimuli, which have recently become a hot topic in brain research, due to their involvement in the pathogenesis of several neurodegenerative and psychiatric disorders. The specific objectives of MRI-STRUCTURE are: 1) to develop a new biophysical model of diffusion MRI in GM, capturing salient aspects of its microstructure; 2) to validate the model by triggering selective activation of different compartments in selected brain areas using established models of inflammation, demyelination and degeneration in rats; 3) to translate this approach to human brain in vivo in a cohort of healthy volunteers (during a secondment in CUBRIC, one of the European hubs for neuroimaging); and 4) to disseminate the framework to a wide clinical audience through a secondment in the startup Mint Labs, and explore its commercial applicability. An instrument with capacity to characterize relevant aspects of tissue microstructure in vivo and noninvasively is expected to have a tremendous impact on our knowledge of the pathophysiology of many brain pathologies, ultimately leading to early diagnosis, better (e.g., personalised) monitoring of the disease course and of the efficacy of new therapies.

Field of Science

/medical and health sciences/basic medicine/pathology

/medical and health sciences/basic medicine/physiology/pathophysiology

Programme(s)

H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

MSCA-IF-2016 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2016

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Research Organisations

EU Contribution

€ 158 121,60

Website

Contact the organisation

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

Deliverables

Deliverables not available

Publications

Peer reviewed articles (7)

Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI

Author(s): Silvia De Santis, Tobias Granberg, Russell Ouellette, Constantina A. Treaba, Elena Herranz, Qiuyun Fan, Caterina Mainero, Nicola Toschi

Published in: NeuroImage: Clinical, Issue 22, 2019, Page(s) 101699, ISSN 2213-1582

DOI: 10.1016/j.nicl.2019.101699

Characterizing Microstructural Tissue Properties in Multiple Sclerosis with Diffusion MRI at 7 T and 3 T: The Impact of the Experimental Design

Author(s): Silvia De Santis, Matteo Bastiani, Amgad Droby, Pierre Kolber, Frauke Zipp, Eberhard Pracht, Tony Stoecker, Sergiu Groppa, Alard Roebroeck

Published in: Neuroscience, Issue 403, 2019, Page(s) 17-26, ISSN 0306-4522

DOI: 10.1016/j.neuroscience.2018.03.048

Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence

Author(s): Silvia De Santis, Patrick Bach, Laura Pérez-Cervera, Alejandro Cosa-Linan, Georg Weil, Sabine Vollstädt-Klein, Derik Hermann, Falk Kiefer, Peter Kirsch, Roberto Ciccocioppo, Wolfgang H. Sommer, Santiago Canals

Published in: JAMA Psychiatry, Issue 76/7, 2019, Page(s) 749, ISSN 2168-622X

DOI: 10.1001/jamapsychiatry.2019.0318

Multishell diffusion imaging reveals sex-specific trajectories of early white matter degeneration in normal aging

Author(s): Nicola Toschi, Rebeca Arrais Gisbert, Luca Passamonti, Santiago Canals, Silvia De Santis

Published in: Neurobiology of Aging, Issue 86, 2020, Page(s) 191-200, ISSN 0197-4580

DOI: 10.1016/j.neurobiolaging.2019.11.014

Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging

Author(s): Silvia De Santis, Wolfgang H. Sommer, Santiago Canals

Published in: ACS Chemical Neuroscience, Issue 10/10, 2019, Page(s) 4187-4189, ISSN 1948-7193

DOI: 10.1021/acschemneuro.9b00481

Evidence for Progressive Microstructural Damage in Early Multiple Sclerosis by Multi-Shell Diffusion Magnetic Resonance Imaging

Author(s): Nicola Toschi, Silvia De Santis, Tobias Granberg, Russell Ouellette, Constantina A. Treaba, Elena Herranz, Caterina Mainero

Published in: Neuroscience, Issue 403, 2019, Page(s) 27-34, ISSN 0306-4522

DOI: 10.1016/j.neuroscience.2019.01.022

Non-invasive MRI windows to neuroinflammation

Author(s): Silvia De Santis, Santiago Canals

Published in: Neuroscience, Issue 403, 2019, Page(s) 1-3, ISSN 0306-4522

DOI: 10.1016/j.neuroscience.2019.01.051

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

Project information

MRI-STRUCTURE

Grant agreement ID: 749506

Status

Closed project

Start date

1 April 2018
End date

31 March 2020

Funded under:

H2020-EU.1.3.2.

Overall budget:

€ 158 121,60
EU contribution

€ 158 121,60

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

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Last update: 5 April 2017

Record number: 209796

Permalink: https://cordis.europa.eu/project/id/749506/results

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