Objective
With this proposal, I propose a new chemical approach inspired by DNA gel electrophoresis to slow down DNA translocation through a graphene nanopore or a nanogap, and to reduce the mechanical fluctuations of the graphene membrane as DNA translocates. Thus far using graphene nanodevices to sequence DNA molecules in real time has been hampered by two major drawbacks: i) the too fast translocation of single DNA molecules through a graphene nanodevice, and ii) the very large low frequency electronic noise presumably due to mechanical vibration of the free-standing graphene membrane in aqueous buffers. Both these phenomena prevent single nucleotide identification (at least compared to biological nanopores). The direct chemical functionalization of graphene film with functional polymeric hydrogels will i) induce electrostatic and chemical affinities between DNA and the functional polymer hydrogel and ii) stabilize mechanically graphene from vibrating. The host group of Dr. Schneider was the first to propose graphene nanopores as single molecule DNA sensors in 2010 and has gained a lot of experience in this field. Dr. Schneider’s group is now approaching DNA sequencing with graphene nanostructures with a strong chemistry component. Schneider’s lab in Leiden is therefore, at the moment, the best place in the world to make this research proposal a success. I do believe this proposal has the potential to lead toward ground-breaking applications in nanopore-based biosensors, particularly for high throughput next generation sequencing applications with graphene nanogaps.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology nanotechnology nano-materials two-dimensional nanostructures graphene
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences genetics nucleotides
- natural sciences chemical sciences electrochemistry electrophoresis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2311 EZ Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.