Objective
The circadian clock directs almost all aspects of diurnal physiology, including metabolism. Defects in circadian rhythms influence physiology and behavior with implications for numerous pathological conditions, including cancer, metabolic syndrome, obesity, diabetes and cardiovascular diseases. By controlling metabolic homeostasis at the cellular level, the clock can directly influence cellular regulatory networks, including those that govern chromatin dynamics. The goal of this proposal is to investigate if metabolic pathways able to influence gene expression via chromatin dynamics are under circadian control and whether these regulatory networks are crucial for the maintenance of a correct metabolic homeostasis. We will test if the clock governs the “methylation potential” of the cell by regulating the diurnal expression of rate-limiting enzymes of methionine metabolism. By using metabolite restriction, pharmacological and gene editing approaches we will disrupt circadian rhythmicity of SAM and SAH. We will then use state-of-the-art methods including, transcriptomics, epigenomics and metabolomics to investigate the impact of this regulatory network on circadian transcriptional regulation, histone methylation dynamics and metabolic homeostasis. By dissecting how circadian regulation, metabolism and epigenetics are interconnected we will gain novel insights into how these factors contribute to normal physiology and disease.
At UCI I will exploit the expertise of the outgoing supervisor in the area of circadian biology, molecular metabolism and epigenetics. Then, at Humanitas University I will refine the knowledge and skills acquired during the outgoing phase, with the final aim of applying them to the cardiovascular field. This will place me in a privileged position to establish myself as a competent researcher within the European Community, in the field of cardiovascular biology, metabolism and epigenetics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20072 PIEVE EMANUELE
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.