Periodic Reporting for period 1 - SINMOF (Synthesis of Spirooxindoles and INdoles pharmaceuticals using Metal-Organic Frameworks )
Reporting period: 2017-06-01 to 2019-05-31
(i) The leading general chemistry journal Angewandte Chemie (October 2017) in collaboration with RTI (USA), showing how a stable and non-toxic solid platform catalyst allows for the transformation of bulky steroids under very mild conditions.
(ii) The leading catalysis journals ChemCatChem (cover), Topics in Catalysis and ACS Catalysis (September 2017, August 2018, November 2019) in collaboration with the Granada University (Spain), tuning MOF catalysts through ion exchange with Cu and Pd active sites or producing catalytic amounts of ZnO/CuO nanoparticles on aluminosilicates for the synthesis of substituted propargylamines, indoles, oxindoles and spirooxindoles N-heterocyclic type pharmaceutically relevant scaffolds under cost-efficient/clean conditions.
(iii) The leading journals in sustainable organic chemistry Green Chemistry and Advanced Synthesis and Catalysis (VIP designation and cover) (April 2018 and September 2018), developing eco-friendly synthesis of substituted indoles and uracil pharmaceuticals by using reusable acid ionic liquids or Cu-Pd redox active MOFs.
(iv) One perspective article in Catalysis Science & Technology and one book chapter (October 2017, April 2018), comparing MOFs and Zeolites or MOFs and Enzymes in organic synthesis in ChemCatChem (invited for the special issue “Sustainable and Affordable Chemistry to Meet Future Challenges in the Pharmaceutical Industry”).
Finally, during this MC fellowship I was commited to supervise, support and develop undergraduate and PhD students (Carlos Márquez, Maxime Stalpaert, Simon Smolders, Jannick Vercammen, Guangxia Fu and Chunmei Jia) and I am co-promotor of one MSc student in catalytic technology (Christophe Kussé), working on Pd containing MOFs as catalyst for the synthesis of neurogenic indoles, and two BSc students (Quinten van Hisberg and Fons Dingenen) in the synthesis of mixed-linker MOFs with catalytic applications in biomass valorization at KU-Leuven.