Objective
Permeability Assay (PAMPA) have limited biorelavance and can often be poorly predictive of of drug permeation, particularly for charged species and for complex membranes such as the BBB and particularly of membrane toxicity which remain key issue leading to high attrition rate and low productivity in the pharmaceutical industry. The proposed fellowship programme aims to address these issues in a very novel way by developing lipid bilayers supported on cutting-edge Plasmonically-Directed Nano-Structured porous arrays. The substrates prepared via a range of fabrication methods, including 2-photon 3D-nanoprinting, will allow for investigation of drug-membrane interactions, and permeability through a unique and novel principle, whereby the arrival time of single or few weakly- or non-fluorescent molecules at plasmonic volume in the nano-/micro-cavity is monitored via enhanced spectroscopic technique. Angle dependent Raman microscopy will permit study independently of the drug-membrane interactions and plasmonic hot spot so both structural and permeation times can be meausered and these studies will be carried out in parallel with Elelctrochemcial impendence spectroscopy of membrane integrity. This approach will dramatically advance the state-of-the-art in membrane assay. In parallel it provide high quality research training to the MRSA fellow along with, supported by the host institution training programme a range of career promoting transferable skills acquired. Leading the fellow to a fully-independent academic position.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences biochemistry biomolecules lipids
- social sciences economics and business economics production economics productivity
- natural sciences physical sciences optics spectroscopy
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.