Objective Esophageal carcinoma (EC) is among the top 10 deadliest cancers worldwide. The current standardtherapy for ES is neoadjuvant (pre-operative) chemoradiation (NACR) followed by surgery. However,only 30% of patients achieve a complete pathological response (CPR) and long-term survival.Understanding the mechanisms of response to NACR is hence pivotal to better stratify patients andinform the design of more efficacious therapies. Evidence from some tumors suggests that NACR is“immunogenic” and stimulates anti-cancer immune responses, which may contribute to the longtermeffects of successful treatments. Tumor neo-antigens, generated by somatically mutatedcancer genes, have been recently implicated in the activation of the most efficient anti-tumor T cellresponse capable of controlling tumor progression, induced by immune checkpoint blockadeimmunotherapy. This raises the question as to whether clinical responses induced by NACR in afraction of ECs may be linked to the stimulation of clinically relevant T cell responses against tumorneoantigens, implying that activating tumor immunity in the non-responding ones may improveclinical responses. Objective of this proof-of-concept study is hence to address this question throughthe implementation of a high-throughput platform to assess neoantigen-specific T cell responses inECs in the course of NACR. Fields of science medical and health sciencesclinical medicinesurgerymedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineimmunologyimmunotherapy Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2016 - Individual Fellowships Call for proposal H2020-MSCA-IF-2016 See other projects for this call Funding Scheme MSCA-IF-EF-SE - Society and Enterprise panel Coordinator OSPEDALE SAN RAFFAELE SRL Net EU contribution € 168 277,20 Address VIA OLGETTINA 60 20132 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 168 277,20
