Objective
Esophageal carcinoma (EC) is among the top 10 deadliest cancers worldwide. The current standard
therapy for ES is neoadjuvant (pre-operative) chemoradiation (NACR) followed by surgery. However,
only 30% of patients achieve a complete pathological response (CPR) and long-term survival.
Understanding the mechanisms of response to NACR is hence pivotal to better stratify patients and
inform the design of more efficacious therapies. Evidence from some tumors suggests that NACR is
“immunogenic” and stimulates anti-cancer immune responses, which may contribute to the longterm
effects of successful treatments. Tumor neo-antigens, generated by somatically mutated
cancer genes, have been recently implicated in the activation of the most efficient anti-tumor T cell
response capable of controlling tumor progression, induced by immune checkpoint blockade
immunotherapy. This raises the question as to whether clinical responses induced by NACR in a
fraction of ECs may be linked to the stimulation of clinically relevant T cell responses against tumor
neoantigens, implying that activating tumor immunity in the non-responding ones may improve
clinical responses. Objective of this proof-of-concept study is hence to address this question through
the implementation of a high-throughput platform to assess neoantigen-specific T cell responses in
ECs in the course of NACR.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-SE - Society and Enterprise panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20132 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.