Objective
The worldwide explosion of obesity has resulted in an ever-increasing prevalence of type 2 diabetes (T2D), a non-communicable disease that affects more than 370 million people worldwide. T2D is characterized by insulin resistance with a relative deficiency in insulin secretion. It is now recognized that there is decreased beta-cell function and mass in T2D but the precise underlying mechanism remains to be determined. Skeletal muscle accounts for >50% of the total glucose uptake in the post-prandial state, it is also the largest organ in non-obese individuals. Recent studies demonstrated that there is conversation between skeletal muscle and beta-cells, and that certain peptides (i.e. myokines) secreted by insulin-resistant skeletal muscle cells may impact negatively on beta-cell function, proliferation and survival in T2D. Nevertheless, other factors than myokines could also be involved in this inter-organ communication. A novel concept suggests microvesicles, such as exosomes, as a new cell-to-cell communication mode. The major goal of the project will be to characterize the different exosomes populations and their impact on islets cells. The findings may have important implications for understanding decreased functional beta-cell mass in diabetes, especially in T2D etiology, and therefore bring new insights into the development of innovative therapies.
To achieve the aims of the innovative translational project, the candidate will be part of one of the European leader research centres on diabetes, trained to promising new research area in inter-organ communication, micro-RNA biology, as well as cutting-edge 'omic' technologies which will perfectly complement her strong knowledge in energy metabolism and physiology and create a rare expertise in candidate's profile. It will provide a unique stepping-stone for her independent research career in Europe and successful collaborations in the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine physiology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-SE - Society and Enterprise panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
67200 STRASBOURG
France
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.