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New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle

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Insights into the N-terminal Cu(II) and Cu(I) binding sites of the human copper transporter CTR1

Author(s): Yulia Shenberger, Ortal Marciano, Hugo E. Gottlieb, Sharon Ruthstein
Published in: Journal of Coordination Chemistry, Issue 71/11-13, 2018, Page(s) 1985-2002, ISSN 0095-8972
DOI: 10.1080/00958972.2018.1492717

The pivotal role of MBD4–ATP7B in the human Cu( i ) excretion path as revealed by EPR experiments and all-atom simulations

Author(s): Zena Qasem, Matic Pavlin, Ida Ritacco, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
Published in: Metallomics, Issue 11/7, 2019, Page(s) 1288-1297, ISSN 1756-5901
DOI: 10.1039/C9MT00067D

Does the ATSM-Cu(II) Biomarker Integrate into the Human Cellular Copper Cycle?

Author(s): Gulshan R. Walke, Sharon Ruthstein
Published in: ACS Omega, Issue 4/7, 2019, Page(s) 12278-12285, ISSN 2470-1343
DOI: 10.1021/acsomega.9b01748

Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts

Author(s): Alessandra Magistrato, Matic Pavlin, Zena Qasem, Sharon Ruthstein
Published in: Current Opinion in Structural Biology, Issue 58, 2019, Page(s) 26-33, ISSN 0959-440X
DOI: 10.1016/

Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins

Author(s): Pavlin, Qasem, Sameach, Gevorkyan-Airapetov, Ritacco, Ruthstein, Magistrato
Published in: International Journal of Molecular Sciences, Issue 20/14, 2019, Page(s) 3462, ISSN 1422-0067
DOI: 10.3390/ijms20143462

An EPR Study on the Interaction between the Cu(I) Metal Binding Domains of ATP7B and the Atox1 Metallochaperone

Author(s): Michael Zaccak, Zena Qasem, Lada Gevorkyan-Airapetov, Sharon Ruthstein
Published in: International Journal of Molecular Sciences, Issue 21/15, 2020, Page(s) 5536, ISSN 1422-0067
DOI: 10.3390/ijms21155536

Cu(I) Controls Conformational States in Human Atox1 Metallochaperone: An EPR and Multiscale Simulation Study

Author(s): Ortal Perkal, Zena Qasem, Meital Turgeman, Renana Schwartz, Lada Gevorkyan-Airapetov, Matic Pavlin, Alessandra Magistrato, Dan Thomas Major, Sharon Ruthstein
Published in: The Journal of Physical Chemistry B, Issue 124/22, 2020, Page(s) 4399-4411, ISSN 1520-6106
DOI: 10.1021/acs.jpcb.0c01744


Author(s): Ruthstein, Sharon; Shenberger, Yulia
Published in: PCT-IL, Issue 2, 2018
DOI: 10.5281/zenodo.3244872