New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle

Project Information

CuHypMECH

Grant agreement ID: 754365

DOI

10.3030/754365

Project closed

EC signature date 30 August 2017

Start date 1 September 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 345,00

EU contribution

€ 1 499 345,00

Coordinated by

BAR ILAN UNIVERSITY
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Make my research project results open to the public

Publications

Peer reviewed articles (12)

The Advantages of EPR Spectroscopy in Exploring Diamagnetic Metal Ion Binding and Transfer Mechanisms in Biological Systems

Author(s): Shelly Meron; Yulia Shenberger; Sharon Ruthstein
Published in: Crossref, Issue 3, 2022, ISSN 2312-7481
Publisher: MDPI
DOI: 10.3390/magnetochemistry8010003

Disrupting Cu trafficking as a potential therapy for cancer

Author(s): Sharon Ruthstein
Published in: Frontiers in Molecular Biosciences, Issue 2296889X, 2022, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2022.1011294

Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion

Author(s): Sharon Ruthstein
Published in: Biophysical Journal, Issue 2, 2022, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2022.02.033

EPR Spectroscopy Provides New Insights into Complex Biological Reaction Mechanisms

Author(s): Sharon Ruthstein
Published in: J. Phys. Chem. B., Issue 15206106, 2022, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.2c05235

Insights into the N-terminal Cu(II) and Cu(I) binding sites of the human copper transporter CTR1

Author(s): Yulia Shenberger, Ortal Marciano, Hugo E. Gottlieb, Sharon Ruthstein
Published in: Journal of Coordination Chemistry, Issue 71/11-13, 2018, Page(s) 1985-2002, ISSN 0095-8972
Publisher: Gordon and Breach Science Publishers
DOI: 10.1080/00958972.2018.1492717

The pivotal role of MBD4–ATP7B in the human Cu( i ) excretion path as revealed by EPR experiments and all-atom simulations

Author(s): Zena Qasem, Matic Pavlin, Ida Ritacco, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
Published in: Metallomics, Issue 11/7, 2019, Page(s) 1288-1297, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1039/C9MT00067D

Does the ATSM-Cu(II) Biomarker Integrate into the Human Cellular Copper Cycle?

Author(s): Gulshan R. Walke, Sharon Ruthstein
Published in: ACS Omega, Issue 4/7, 2019, Page(s) 12278-12285, ISSN 2470-1343
Publisher: ACS
DOI: 10.1021/acsomega.9b01748

Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts

Author(s): Alessandra Magistrato, Matic Pavlin, Zena Qasem, Sharon Ruthstein
Published in: Current Opinion in Structural Biology, Issue 58, 2019, Page(s) 26-33, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2019.05.002

Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins

Author(s): Pavlin, Qasem, Sameach, Gevorkyan-Airapetov, Ritacco, Ruthstein, Magistrato
Published in: International Journal of Molecular Sciences, Issue 20/14, 2019, Page(s) 3462, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20143462

An EPR Study on the Interaction between the Cu(I) Metal Binding Domains of ATP7B and the Atox1 Metallochaperone

Author(s): Michael Zaccak, Zena Qasem, Lada Gevorkyan-Airapetov, Sharon Ruthstein
Published in: International Journal of Molecular Sciences, Issue 21/15, 2020, Page(s) 5536, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21155536

Cu(I) Controls Conformational States in Human Atox1 Metallochaperone: An EPR and Multiscale Simulation Study

Author(s): Ortal Perkal, Zena Qasem, Meital Turgeman, Renana Schwartz, Lada Gevorkyan-Airapetov, Matic Pavlin, Alessandra Magistrato, Dan Thomas Major, Sharon Ruthstein
Published in: The Journal of Physical Chemistry B, Issue 124/22, 2020, Page(s) 4399-4411, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.0c01744

Cellular Uptake of the ATSM

Author(s): Sharon Ruthstein
Published in: ChemistryOpen, Issue 4, 2021, ISSN 2191-1363
Publisher: Wiley
DOI: 10.1002/open.202100044

Other (1)

COPPER-CONTAINING COMPLEX AND USES THEREOF

Author(s): Ruthstein, Sharon; Shenberger, Yulia
Published in: PCT-IL, Issue 2, 2018
Publisher: patentscope
DOI: 10.5281/zenodo.3244872